Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Neuromuscular junctions"”.
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Facilitation At Neuromuscular Junctions in Crayfish Deep Abdominal Extensor Muscles
… facilitation and excitability was proposed. The neuromuscular junctions of the two muscles had significant differences in the means of ejp's at 1 Hz, ejp's at 10 Hz, and indices of facilitation (Fe). Fe decreased with fatigue in experiments where the muscle fibers were stimulated at 10 Hz until …
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Neuromuscular Junctions in Androgen Sensitive Muscles: A Model for Synaptic Plasticity
… the nature of the effects of androgens on the neuromuscular junctions in these muscles. I measured the relative abundance of the various molecular forms of acetylcholinesterase (AChE) in muscles of the zebra finch. Castration causes a large decrease in AChE activity but has little or no effect …
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Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions
The Drosophila neuromuscular junction (NMJ) is capable of rapidly budding new presynaptic varicosities over the course of minutes in response to elevated neuronal activity. Using live imaging of synaptic growth, we characterized this dynamic process and demonstrate that rapid bouton budding …
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Emergence of functional neuromuscular junctions in an engineered, multicellular spinal cord-muscle bioactuator
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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UCHLI in the Mammalian Nervous System
… and established a timecourse of degeneration of neuromuscular junctions. Presented in this thesis is the culmination of these studies.
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Microfluidic and optogenetic technologies to model spinal cord development and neuromuscular junction formation and function
… ligand receptors. Finally, they form neuromuscular junctions, the synapses that transmit electrical signals to the muscle effectors. Failure for these motor neurons to develop or function properly, caused by developmental or neurodegenerative genetic disorders, or as a result of …
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Characterization of synaptotagmin 7 function in neurotransmission and its subcellular localization at synapses
… release probability is elevated 2-fold at larval neuromuscular junctions (NMJs) in Syt7 mutants. No structural changes were identified that could contribute to the elevated evoked response.
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Junction Specificity and Transmembrane Linkages of Integrins
… P4B2, which localizes to multiple adhesion junctions, namely, a subset of focal adhesions, the Z-disc of muscle, and neuromuscular junctions. Immunopurification of the antigen to this antibody from chicken brain tissue yielded a complex of three prominent proteins with mobilities of 36, 30 …
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The role of ras signaling associative learning and memory in Drosophila
… gene. Studies on synaptic morphology at larval neuromuscular junctions revealed an increased number of presynaptic varicosities in the ras mutants. Flies carrying a dominant-negative or -active form of a ras transgene showed a learning impairment, when expression of the transgene occurred in the …
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The isolation of syaptic myonuclei and Schwann cell nuclei for DNA analysis from human skeletal muscle
The neuromuscular junction is a critical component of the motor system that enables transmission of impulses from the alpha-motor nerve to muscle fibers. Cerebral palsy is a neuromotor disorder that has been characterized by deficits in the central nervous system and, more recently, disruptions in …
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TGF-beta signaling at the cellular junctions
… the developing wing epithelial cells and at the neuromuscular junctions. Cell culture studies have suggested that cells modulate morphogenetic signaling by expressing the receptors and secreting the ligand in spatially defined areas of the cell. Indeed, I have found that TGF-beta ligands, …
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EGFR signaling regulates synaptic connectivity via Gurken
… morphology and growth at the Drosophila larval neuromuscular junction: NMJ). My screen identified several mutants with defects in various aspects of synaptic development. I pursued a more in depth analysis of an identified mutant, happyhour, with defects in synaptic target selection. Synaptic …
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THE ROLE OF SKELETAL MUSCLE SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) ON THE HEALTH AND MAINTENANCE OF THE MURINE MOTOR UNIT
… the structure of gastrocnemius associated neuromuscular junctions of 120d mice and found that there is a presynaptic decrease of vesicle acetylcholine transporter and an increased probability of junction fragmentation in muscle BDNF knockout mice. Taken altogether these findings suggest …
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Retrograde regulation of activity-dependent synaptic growth by Synaptotagmin 4
… localized to postsynaptic vesicles at Drosophila neuromuscular junctions (NMJs), suggesting a role in Ca2+-dependent release of retrograde signals. Here we demonstrate that fusioncompetent Syt 4 vesicles localize postsynaptically in Drosophila central nervous system (CNS) neurons, suggesting Syt 4 …
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Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
… co-innervate postsynaptic muscles at Drosophila neuromuscular junctions (NMJs). After identifying drivers for each neuronal subtype, I performed ablation or genetic manipulations to alter neuronal activity and examined the effects on synaptic innervation and function. Ablation of either Ib or Is …
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
… terminal is an essential function of neuromuscular junctions to meet their high energy demands. Damaged or dysfunctional mitochondria can put stress on these synaptic junctions, ultimately leading to the degradation of the synapse and subsequent cell death. Dysfunctional mitochondria …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
… of retrograde transport is a hallmark of several neuromuscular diseases, including SBMA, Huntington’s disease, and ALS. The roles of BDNF and TrkB are not well-characterized in muscle or motor neurons. This study addressed the function of TrkB in neuromuscular junctions (NMJs) and its roles in …
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Implementation of circFISH to quantify the expression and cellular localization of circNFIX in cerebral palsy
… volume, increased sarcomere length, disrupted neuromuscular junctions (NMJ) and reduced satellite-cell (SC) number. However, the underlying mechanisms contributing to such muscle alterations remain elusive. Regulatory non`-coding RNAs called circular RNAs (circRNAs) have been studied to play …
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The structure and function of Gene's organ and its associated glands in ticks
… L-aspartate as excitatory transmitters at the neuromuscular junctions.
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