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Showing 1 to 20 of 98 for “"Neuromuscular junction"”.
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Transmission at the mammalian neuromuscular junction
… techniques were evolved. The concept of the neuromuscular junction as a physiological entity dates from the researches of Claude Bernard on in 1850-57. The work of Langley (1950, 1907) indicated the pharmacological specificity of the muscle junctional region. Following the demonstration of …
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Transmission at the mammalian neuromuscular junction
… techniques were evolved. The concept of the neuromuscular junction as a physiological entity dates from the researches of Claude Bernard on in 1850-57. The work of Langley (1950, 1907) indicated the pharmacological specificity of the muscle junctional region. Following the demonstration of …
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Roles Of Neuregulin1 In Neuromuscular Junction Development
<p>Neuromuscular junction (NMJ) development is a multistep process mediated by coordinated interactions between nerve terminals, target muscles, and peri-synaptic glial cells, and thus requires reciprocal signals derived from every cell type. Neuregulin1s (NRG1s) are a family of predominantly …
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Phenotypic characterization of hangover at the neuromuscular junction
Ethanoltoleranz beruht vermutlich auf Veränderung in synaptischer Plastizität; da die Mechanismen, die zu dieser Anpassung der Synapsen führen, in hang-Mutanten offensichtlich defekt sind, war es Ziel dieser Arbeit zu erklären, wie HANG zu synaptischer Plastizität beiträgt. In diesem Zusammenhang …
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Neuromuscular junction formation in Extraocular muscles of embryonic mice
… a muscle, a chemical synapse, referred to as a neuromuscular junction (NMJ), is formed. To pinpoint the time of innervation the cranial nerves and NMJs of extraocular muscles were labelled using immunohistochemistry and bungarotoxin between E11.5-E14.5. Extraocular muscles exist as a mass of …
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Cellular organisation of peripheral nerve and the neuromuscular junction
… propagation of the action potential. At the neuromuscular junction, terminal Schwann cells are necessary for stability of motor nerve terminals and motor endplates and they are involved in plastic responses of the neuromuscular system to injury and in disease.
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COMPARATIVE STUDY ON DROSOPHILA LARVAL LOCOMOTION AND NEUROMUSCULAR JUNCTION MORPHOLOGY
… phenotypic variations in locomotion patterns and Neuromuscular Junction morphology within related Drosophila species, D. melanogaster, D. simulans, D. sechellia, D. pseudoobscura, and D. busckii, and demonstrate possible mechanisms underlying these phenotypic differences. We describe larval …
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Synaptic physiology of the developing <i>Drosophila</i> neuromuscular junction
Während der Entwicklung von sowohl vertebraten, wie auch invertebraten Nervensystemen, ist eine bedeutende Zunahme der Zahl der Synapsen und eine konstante strukturelle und funktionelle Veränderung schon etablierter synaptischer Verbindungen zu verzeichnen. Spezielle Formen solcher synaptischer …
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Regulation of synaptic structure and function at the Drosophila neuromuscular junction
Neuronal communication requires a spatially organized synaptic apparatus to coordinate neurotransmitter release from synaptic vesicles and activation of postsynaptic receptors. Structural remodeling of synaptic connections can strengthen neuronal communication and synaptic efficacy during …
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In vivo imaging of long-term changes in the Drosophila neuromuscular junction
Bisher war es nicht möglich, die Entstehung neuer glutamaterger Synapsen in vivo zu beobachten. In dieser Arbeit wurden Protokolle etabliert, die die Beobachtung einzelner postsynaptischer Rezeptorfelder in einem definierten Zeitintervall erlauben. Hierzu wurden transgene Fliegenstämme etabliert, …
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Synaptic Homeostasis at the Drosophila Neuromuscular Junction: Molecular Mechanisms and Developmental Adaptation
<p>No abstract available</p>
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Microfluidic and optogenetic technologies to model spinal cord development and neuromuscular junction formation and function
… ligand receptors. Finally, they form neuromuscular junctions, the synapses that transmit electrical signals to the muscle effectors. Failure for these motor neurons to develop or function properly, caused by developmental or neurodegenerative genetic disorders, or as a result of …
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Structural and Functional Aspects of Dystroglycan During Agrin -Mediated Acetylcholine Receptor Clustering at the Mammalian Neuromuscular Junction
Prior studies on dystroglycan support dystroglycan as an agrin-binding protein. More specifically, data suggests that the carbohydrate residues on dystroglycan may be involved in binding to agrin. However, genetic and functional studies on dystroglycan's role in agrin-mediated acetylcholine …
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Synaptic structure and function at the Drosophila larval neuromuscular junction : a molecular analysis of complexin and radish
From yeast to humans, the fusion of vesicles with target membranes is driven by the formation of a parallel four-helix bundle of SNARE proteins that are present on both the vesicular (v-SNAREs) and target plasma membranes (t-SNAREs). The full zippering of this bundle is thought to provide the …
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Decreased transmitter release conferred by a mutation in the slowpoke-encoded calcium-dependent potassium channel gene at the Drosophila neuromuscular junction
… larvae. Defects in synaptic transmission at the neuromuscular junction were analyzed electrophysiologically. slo mutants show significant reductions in transmitter release. Also, slo mutations paired with hyperexcitable mutants (Shaker, ether a go go) and/or pharmacological agents …
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The isolation of syaptic myonuclei and Schwann cell nuclei for DNA analysis from human skeletal muscle
The neuromuscular junction is a critical component of the motor system that enables transmission of impulses from the alpha-motor nerve to muscle fibers. Cerebral palsy is a neuromotor disorder that has been characterized by deficits in the central nervous system and, more recently, disruptions in …
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