Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Neuromuscular diseases"”.
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Image analysis for diagnostic support in biomedicine: neuromuscular diseases and pigmented lesions
… para ayuda al diagnóstico de enfermedades neuromusculares a partir de imágenes de microscopía de fluorescencia y análisis de lesiones pigmentadas a partir de imágenes dermoscópicas. El diagnóstico de enfermedades neuromusculares se basa en la evaluación visual de las biopsias musculares por …
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Assessment of Electrode Configurations of Electrical Impedance Myography for the Evaluation of Neuromuscular Diseases
… a painless, noninvasive approach to measure the neuromuscular disease status. EIM parameters- resistance (R), reactance (X) and phase (θ) depend significantly on subcutaneous fat thickness, muscle size and inter electrode distance. The objective of this research is to find an electrode …
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Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device
<p>Neuromuscular diseases manifest by a handful of known phenotypes affecting the peripheral nerves, skeletal muscle fibers, and neuromuscular junction. Common signs of these diseases include demyelination, myasthenia, atrophy, and aberrant muscle activity—all of which may be tracked over time …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
… of retrograde transport is a hallmark of several neuromuscular diseases, including SBMA, Huntington’s disease, and ALS. The roles of BDNF and TrkB are not well-characterized in muscle or motor neurons. This study addressed the function of TrkB in neuromuscular junctions (NMJs) and its roles in …
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Nuclear Encoded Proteins Important in Mitochondrial Genome Stability
… in the mtDNA are associated with certain neuromuscular diseases as well as contributing to the aging process. The focus of this research is to identify genes that contribute to the maintenance of the mtDNA. Our data from genetic assays indicate that loss of the Clu1p protein exhibits an …
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Patient and family experiences with peri-operative care for spinal fusion surgery
… care coordination.1-3 Many complex children with neuromuscular diseases have scoliosis, or a deformity of the spine. Often, scoliosis in these patients affects multiple organ systems and requires spinal fusion surgery to repair the deformity and decrease the likelihood of further organ damage.4,5 …
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Diagnosi molecolare della Distrofia Muscolare di Duchenne e della Neurofibromatosi tipo 1 con la tecnologia di sequenziamento Next Generation
… (DMD/BMD) are the most frequent inherited neuromuscular diseases caused by mutations in the dystrophin gene (DMD). Neurofibromatosis type 1 (NF1), caused by mutations in the neurofibromin gene (NF1), is a multisystem genetic disorder that commonly is associated with cutaneous, neurologic, …
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Matrix-mediated formation & innervation of skeletal myotubes
… behaviors involved in tissue formation and diseases. One of the goals of tissue engineering is to be able to recapitulate the in vivo microenvironment of cells in vitro. As such, a lot of attention has been focused on the development of materials that are able to present various aspects of …
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Classification of P300 from non-invasive EEG signal using convolutional neural network
… is a communication tool for the patients of neuromuscular diseases. The efficiency of such a system largely depends on the accurate and reliable detection of the brain signal employed in its operation. P300 Speller, a well-known BCI system, which helps the user select the desired alphabet in …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS
… several tissue types including skeletal muscle. Neuromuscular diseases (NMDs) are characterized by the degeneration of motorneurons and/or associated skeletal muscles, and reduced BDNF is implicated in NMDs. Using Cre-Lox gene recombination technology our lab generated transgenic mice in which …
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
… terminal is an essential function of neuromuscular junctions to meet their high energy demands. Damaged or dysfunctional mitochondria can put stress on these synaptic junctions, ultimately leading to the degradation of the synapse and subsequent cell death. Dysfunctional mitochondria …
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Tracking individual disease-trajectory of patients with neuromuscular disorders (Duchenne muscular dystrophy and spinal muscular atrophy)
Neuromuscular diseases represent a diverse group of complex genetic disorders. In conditions such as Duchenne muscular dystrophy (DMD) and Spinal muscular atrophy (SMA), progressive motor impairment limiting activities of daily life is a common and central clinical feature. Over the last 15 years, …
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Role of DNA Mismatch Repair in Disease-associated Trinucleotide Repeat Instability
… are known to cause numerous neurological and neuromuscular diseases. The mechanism of DNA instability is believed to involve the formation of slipped-repeat structures, and ongoing expansion requires the presence of functional mismatch repair (MMR) proteins. It is known that MMR efficiency is …
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NEW PERSPECTIVES ON POSTURAL CONTROL IN CHILDREN AND ADULTS
… analysis of children with neurological or neuromuscular diseases with the aim of differentiating the pathologies under study; the others (RA-2 and RA-3) focused on gait initiation (GI). Specifically, I started a study (RA-2) to assess the existence of Anticipatory Postural Adjustments …
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Common Pathophysiological Features of Charcot-Marie-Tooth Disease
… of 1 in 2,500, CMT is the most common inherited neuromuscular disorder and among the most common of all Mendelian diseases. Despite advances in the understanding of CMT genomics, a significant number of CMT patients remain genetically undiagnosed, and disease-modifying therapeutics are not …
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A distance adaptable brain-computer interface based on steady-state visual evoked potential
… output pathway between patients suffering from neuromuscular diseases and their external environment. BCI requires at least one brain signal as input in order to interpret the intent of the user. Non-invasive electroencephalography (EEG) is the most common and favourite method for acquiring …
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Expression der Isoformen des „Myosin Heavy Chain“ (neonatal, developmental und fast) sowie N-CAM bei myogenen und neuromuskulären Erkrankungen
In den letzten Jahren ist durch die Immunhistochemie das Verständnis für die Pathogenese vieler Muskelerkrankungen enorm gestiegen. Es wurden viele monoklonale Antikörper gegen verschieden Muskelproteine entwickelt, die eine exakte Diagnose der verschiedenen Erkrankungen enorm erleichterten oder …
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Development and Validation of Experimental Protocol and Guidelines for Non-Invasive Superficial and Deep Muscle Electromyography in the Forearm
… ± SD; age: 24 ± 3 years) without any history of neuromuscular diseases or disabilities were recruited for the study. Each participant completed five experimental runs of the five MP variations while the EMG and flex sensor data was recorded. Independent Component Analysis (ICA) was used as the …
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