Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"Neuromodulatory"”.
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Synthesis of neuromorphic circuits with neuromodulatory properties
The field of neuromorphic engineering shows great promise in delivering novel devices inspired by biological principles that would undertake sensory and processing tasks with an unprecedented level of efficiency. In order to achieve that, engineers are required to understand and implement the many …
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Sensory and Neuromodulatory Entrainment of Foraging States in C. Elegans
… that mutants lacking sensory transduction or neuromodulatory signaling each show dysregulated behavioral states surrounding food leaving behavior. In C. elegans, animals spontaneously alternate between roaming and dwelling states in environments that contain a uniform food density. However, I …
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Modeling projection neuron and neuromodulatory effects on a rhythmic neuronal network
… activity of many neural networks. In particular, neuromodulatory substances, which are often released by projection neurons, alter the cellular and/or synaptic properties within a target network. However, neural networks in turn influence projection neuron input via synaptic feedback. This …
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Aging with Stroke: Using Functional Electrical Stimulation as a Neuromodulatory Intervention Supplement
… Functional Electrical Stimulation (FES) is a neuromodulatory adjunct that can improve muscular activation and cortical engagement, but its translation into scalable, home- or community-based paradigms remains limited. Objective: This dissertation contains research studies including …
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Investigating the effects of neuromodulatory training on autistic traits: a multi-methods psychophysiological study.
Autism spectrum disorder (ASD) is characterized by noticeable difficulties with social interaction and communication. Building on past research in this area and with the aim of improving methodological perspectives, a multi method approach to the study of ASD, mirror neurons and neurofeedback was …
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Characterization of Neuromodulatory and Neurotoxic Marine Natural Products Using Microseparations, NMR and Mass Spectrometry
A number of different neuromodulatory compounds from marine species are examined including toxins from venomous cone snails. Conotoxins represent a wealth of neuropharmacologically active peptides as well as tools for basic research and a review of cone snails and their toxins is included.
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From Small Molecules to Neurotoxins: Characterizing Neuromodulatory Compounds Using Liquid Chromatography Coupled to Mass Spectrometry
Thus, this work demonstrates mass spectrometric approaches for analyzing biological samples from a variety of animal models resulting in detailed chemical and structural characterization of highly modified toxins, neuropeptides, and small molecules, which can ultimately contribute to our …
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Translation and transcription are required for endogenous bursting after long term removal of neuromodulators
Motor pattern-generating networks depend on neuromodulatory inputs to regulate the network activity. The pyloric network of the Cancer borealis stomatogastric ganglion (STG), a rhythmic motor pattern-generating network, requires modulatory inputs to generate this activity. When neuromodulatory …
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The Octopaminergic Modulatory Circuitry of the Drosophila Larval Mushroom Body Calyx
How are neuromodulatory networks organised to adapt sensory discrimination for different contexts? I hypothesised that neurons within a sensory circuit express different neuromodulatory receptors for differential modulation. Here I aimed to use the simple and genetically amenable Drosophila larval …
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Neuromodulation Based Control of an Autonomous Robot
<p>The neuromodulatory systems in the brain of a vertebrate help regulate its decision making in response to the sensory signals from the environment. These neuromodulators influence a vertebrate’s behaviors like focusing attention, cautious risk-aversion and curiosity-seeking exploration. The main …
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Motor and Neurophysiological Effects of Ischemic Conditioning (IC) and Tele-Based IC in Chronic Stroke
… control. These findings demonstrate the acute neuromodulatory effects of IC, though validation in larger cohorts is needed. Building on these results, a novel tele-IC paradigm—comprising seven remotely delivered sessions over two weeks—was found to be safe, feasible, and effective for …
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Acting on Behaviorally Relevant Events and the Impact this has on Attention & Memory
… candidate mechanism is the locus coeruleus neuromodulatory system. The third article investigates how, using functional magnetic resonance imaging, methodological decisions will affect characterization of this system's functional connectivity in the brain. In the fourth article, the locus …
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Building and characterising the neuropeptidergic connectome of Caenorhabditis elegans
… and analysis for a whole-organism level map of neuromodulatory connections in C. elegans and the tools I developed to build and characterise it. Specifically, I focused on the abundant and complex but mostly unstudied neuropeptidergic connections. To build the map of neuropeptidergic connections …
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Neuromodulation Based Control of Autonomous Robots on a Cloud Computing Platform
… neural network (SNN) is used to model the neuromodulatory function for generating context based behavioral responses of the robots to sensory input signals. The neural network incorporates three types of neurons- cholinergic and noradrenergic (ACh/NE) neurons for attention focusing and …
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The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes
… of learning and memory are modulated by these neuromodulatory systems. Using optogenetic stimulation or silencing, this thesis aims to investigate the effects of cholinergic and dopaminergic modulation on various hippocamal learning and memory processes. To understand how these neuromodulatory …
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IMAGING THE GLUTAMATERGIC SYSTEM WITH GLUCEST MRI: CYTOARCHITECTURE, AGING, AND INTERVENTION
… underpinnings of aging, depression, and neuromodulatory intervention using GluCEST.The thesis comprises four interconnected studies. First, we use multimodal analysis to reveal that cortical GluCEST correlates with normative glutamatergic receptor density maps derived from positron …
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Genetic and Neural Circuit Analyses of Sickness and Foraging Behaviors in C. elegans
… in C. elegans. In Chapter 2, we show that neuromodulatory pathways linked to stress and satiety are recruited upon pathogen infection to drive sickness behaviors. These pathways include FMRFamide peptides and the TGF-beta/DAF-7 neuromodulator, which are released from distinct neural sources …
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A computational study of the origin of brain oscillations at multiple scales
… by variations in the activity of ascending neuromodulatory systems. Noradrenergic Locus Coeruleus (LC) is a major neuromodulatory system and is believed to regulate the excitability of cortical targets by an en-masse synchronous increase of firing, and the changes in excitability. A recent …
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Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation
… of K<sup>+</sup> currents is gated by the neuromodulatory environment and can be altered depending on the activation of a ligand-gated peptide receptor. This study demonstrates novel findings of interactions between metabotropic receptor activation and modulation of highly K^+ currents …
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