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Showing 1 to 9 of 9 for “"Neuromelanin"”.
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Isolierung und Charakterisierung Neuromelanin-assoziierter Proteine aus Neuromelanin-Granula des menschlichen Gehirns mittels subzellulärer Proteomanalyse
… stehen Untersuchungen zur Bildung des Pigments Neuromelanin, das die Ursache für die dunkle Farbgebung der humanen Substantia nigra pars compacta ist. Eine Beteiligung von Neuromelanin an den pathobiochemischen Ereignissen bei Parkinson-Krankheit erklärt das klinische Interesse an Neuromelanin. …
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Quantifying Neuromelanin Content Across Varying Magnetic Field Strengths: A Comparative Analysis
Neuromelanin (NM) is an insoluble dark pigment molecule that is found in the substantia nigra of the human brain. Due to its paramagnetic nature, NM can be imaged using MRI in the form of neuromelanin sensitive contrast. This method, known as Neuromelanin Sensitive Magnetic Resonance Imaging …
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The connection between the triple network model and locus coeruleus integrity in those exhibiting inattentive symptoms
… have been performed. In the first analysis, LC neuromelanin contrast was regressed onto ADHD symptom report for 141 individuals across the lifespan, finding a significant negative relationship between neuromelanin in the right hemisphere of the LC and inattentive symptom report. A second …
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CARATTERIZZAZIONE DEI PIGMENTI DELL'INVECCHIAMENTO NEL CERVELLO UMANO:NEUROMELANINA E LIPOFUSCINE
Neuromelanin and lipofuscin are two pigment that both accumulate in central nervous system with aging. The presence and the morphology of these substances have been described more than one century ago but in the past the two pigments haven’t been unmistakably distinct. Today is important to …
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STUDIO DEGLI ADDOTTI CATECOLAMMINE-PROTEINE IN SOSTANZA NERA E NEL PUTAMEN UMANI
… of both areas contain a melanic pigment called neuromelanin. This pigment accumulates linearly during aging and originates from an excess of free cytosolic dopamine. Dopamine, like other catecholamines, can easily oxidize to its corresponding quinone when free in the cytosol. Dopamine-quinone is …
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Identification and biophysical characterization of two intralysosomal pigments with free-radical properties and their synthetic models: Human neuromelanin and the minocycline-induced thyroid pigment
… pigments with paramagnetic properties: human neuromelanin, a natural pigment of the substantia nigra presumed to derive from the neurotransmitter dopamine (DA), and a pigment induced in human and canine thyroids by administration of the tetracycline antibiotic minocycline. Using bovine eye …
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Quantifizierung und zelluläre Lokalisation von Eisen in der Substantia nigra bei Patienten mit Parkinsonscher Erkrankung und gesunden Kontrollen
… der Haupteisenspeicherformen Ferritin und Neuromelanin darzustellen sowie eine eventuelle Kolokalisation mit Gliazellarten aufzudecken. Quantitativ sollte eine Bestimmung des Gesamteiseins und der differentiellen ortsaufgelösten zellulären Eisenkonzentration erfolgen, um direkte …
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Mitochondriale DNA Mutationen und Untersuchungen zum oxidativen Stress beim idiopathischen Parkinsonsyndrom
… nachgewiesen worden. Erhöhte Eisenwerte in Neuromelaninaggregationen, sowie verringerte Ferritinspiegel unterstützen diese Untersuchungen (Cadet, 2001; Dexter et al., 1987, 1989b; Riederer et al., 1989; Sofic et al., 1988). Besonders anfällig für reaktive Sauerstoffverbindungen im Gehirn ist …