Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 282 for “"Neurological disorders"”.
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Kynurenines in neurological disorders
… kynurenine pathway is thought to be involved in neurological disorders but its precise role and the mechanisms involved have yet to be established. Tryptophan can be metabolised via this pathway to produce the neurotoxic N-methyl-D-aspartate (NMDA) receptor agonist, quinolinic acid (QUIN), and …
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Development of gene therapies for treatment of neurological disorders
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Chemometrics and NMR spectroscopy for metabolomics analysis of neurological disorders
Contains fulltext : 94175.pdf (Publisher’s version ) (Open Access)
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Modeling Complex Neurological Disorders With Human Induced Pluripotent Stem Cells
The etiology of many complex neurological disorders, including schizophrenia (SZ) and HIV-Associated Neurocognitive Disorders (HAND), are still unknown, partly due to a lack of accurate models. Human-induced pluripotent stem cells (HiPSCs), which can be differentiated into any cell type and capture …
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Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
… of ischemic stroke and, potentially, other neurological disorders by studying their distribution and degradation. Finally, to further investigate the versatility and therapeutic potential of IN GNPs, we have applied our technology to the delivery of estrogen post-ischemia. The use of …
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Phytochemical Investigation of Psychoactive Medicinal Plants for the Treatment of Neurological Disorders
Neurological disorders include disorders such as migraine, tension-type headaches, Parkinson’s disease (PD), epilepsy, dementia, and Alzheimer’s disease (AD). Globally, PD is the second most comneurodegenerative disorder following AD. In developed countries, PD affects 1% of all population over 60 …
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UNRAVELING THE EFFECTS OF NEUROREHABILITATION IN PERSONS WITH NEUROLOGICAL DISORDERS: RECOVERY VERSUS COMPENSATION
This thesis investigates the mechanisms behind motor improvements in people with multiple sclerosis (PwMS), focusing on the concepts of recovery and compensation as outlined in Levin’s theoretical framework. This framework identifies three levels of motor recovery and compensation: functional, …
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Integrating mechanistic insights and models with machine learning: Applications in addressing neurological disorders
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Modulation of BAZ2 Proteins as a Potential Therapeutic Strategy in Cancer and Neurological Disorders
The complex landscape behind protein homeostasis involves a highly sophisticated system devoted to maintaining cellular balance and preventing dysfunction. In this context, the cellular machinery acts as a quality control mechanism, rapidly identifying and eliminating proteins that could impair …
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Microelectrode Array Modeling of Genetic Neurological Disorders in the Era of Next Generation Sequencing
… of the genetic etiologies of a number of neurological disorders. Parallel advancements in predictive software, for example, have allowed for the annotation of potentially pathogenic variants. However, the development of appropriate systems to functionally interpret variants and identify …
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Proteomics and peptidomics for investigating metabolic and neurological disorders via liquid chromatography-mass spectrometry
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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A biocompatible, local drug delivery platform for the chronic treatment of neurological disorders of the brain
Many neurological disorders are now classified as circuit disorders, in which the underlying pathology arises from a failure in dynamic communication between anatomically distinct regions of the brain. Systemic therapies are often not effective due to their untargeted nature. The injectrode is a …
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Mental Illness and Neurological Disorders in Long-Term Care: Certified Nursing Assistants' Perception of the Initial Training Program
… for patients diagnosed with mental illness and neurological disorders living in long-term care facilities. An influx of patients diagnosed with these conditions is partly due to the reduction of mental health facilities and services for the elderly population. The Texas 100-hour Certified …
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Characterisation of substance P and transient receptor potential melastatin channel messenger RNA and protein expression in acute and chronic neurological disorders.
… understanding of the pathophysiology of these disorders at a molecular level. Recent studies from our laboratory have demonstrated a link between the neuropeptide, substance P (SP), and the development of cerebral oedema and neurologic deficits following TBI, which are attenuated with the …
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Psychiatric disorders as an outcome of neurological insult : a computation of relative risk
… was to examine the relative risk of psychiatric disorders occurring in patients diagnosed with neurological disorders. This study separately computed the relative risk ratios for identified psychiatric disorder (i.e., anxiety, mood disorders, somatization, schizophrenia, alcohol abuse, and …
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Temporal and spatial muscle synergy features and its neural origins during sit-to-stand and stand-to-sit tasks
… crucial for independent living. Many people with neurological disorders that lack neuromuscular control lose the ability to perform the transition tasks normally. Several muscles act together to achieve these motions and the inability to perform these daily life tasks, therefore, present the need …
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The potential commercialization of neuronal replacement therapy using smart polymers
… neuronal outgrowth and promises a novel cure for neurological disorders caused by localized sites of brain damage, such as Parkinson's disease, stroke, and spinal injury. This chip is being researched in the MIT laboratories of Drs. Robert Langer and Mriganka Sur. My thesis addresses the …
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Developmental Plasticity of Language Representation in Healthy Subjects and Children with Medically Intractable Epilepsy
… in healthy children and/or individuals with neurological disorders arising in childhood. In the first study, the role of pathology type on interhemispheric plasticity of language was determined by comparing lateralization in children with developmental, acquired, and tumour pathologies. …
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Development of microfluidic systems for studying functional connectivity between in vitro neuronal co-cultures
… individuals. This is highlighted during neurological disorders that can have a devastating impact on the sufferer's aptitude and quality of life. There is much which is not yet understood about what bhappens during neurological disorders including the changes which occur at a cellular …
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