Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 124 for “"Neurological diseases,"”.
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Machine Learning Applications For Neurological Diseases
Neurological conditions affect the brain and other parts of the nervous system. This includes neurodegenerative diseases like Huntington’s Disease, psychiatric conditions like schizophrenia, and brain cancers like glioblastoma. These conditions are particularly challenging to study because they …
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
… aetiological agents for a variety of autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus, and multiple sclerosis (MS), and have been detected in a variety of tumours. The study aims to develop tools to detect and investigate human endogenous retroviruses in …
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Oxidative stress markers in neurological diseases and disorders: electrochemical detection of hydrogen peroxide and nitric oxide
… H2O2 as oxidative/nitrosative stress markers in neurological disease and dysfunction. As such the role of oxidative/nitrosative stress in Parkinson’s disease (PD) and autism spectrum disorders (ASDs) is investigated in this thesis. The novel detection of NO in a propionic acid (PPA) induced …
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Standardizing a freely-behaving canine videofluoroscopic swallow study protocol to investigate dysphagia in primary aging and neurological diseases
… biomarkers of dysphagia in primary aging and neurological disease conditions. A VFSS protocol was established using 49 dogs, divided into seven conditions: control, canine degenerative myelopathy, Batten disease, cricopharyngeal dysfunction, cerebellar ataxia, megaesophagus, and dysphagia of …
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O uso medicinal do canabidiol e seus meandros burocrático-legal
… A problem arises for people suffering from neurological diseases and sees Cannabidiol as an alternative for the relief of their symptoms, Taking into account that this substance is not released by Brazilian legislation. However, Pharmaceutical Assistance and Health Care are foreseen in the …
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The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study
… neurocognitive disorders (HAND), a spectrum of neurological diseases which includes HIV-associated dementia (HAD), a debilitating sUb-cortical dementia. HIV-related cognitive impairment is a primary neurological complication of HIV infection, as opposed to neurological diseases secondary to …
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Effect of low endogenous brain-derived neurotrophic factor levels on striatal dopamine dynamics
<p>Many neurological diseases and disorders are a result of alterations with neurotransmitters, neuromodulators, and/or proteins. Specifically, one protein that has been linked to numerous neurological diseases and disorders such as Parkinson's disease, Huntington's disease, addiction, attention …
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Understanding and stratifying brain health through blood-based omics data
… of genetics and the environment. Age-related neurological diseases are a growing burden on healthcare systems and society. Individuals that do not have overt diagnoses of neurological diseases will still experience declines in cognitive ability and reductions in grey matter volumes as they …
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Bestimmung von 3-Nitrotyrosin im Liquor als Hinweis für nitrosativen Stress
… plays a role or even causes various neurological diseases in children. In literature there have been several examples of neurological diseases which seem to caused or at least influenced by nitrosative stress, such as Alzheimers disease, ALS, inflammations, multiple sclerosis etc. …
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Optimization, random resampling, and modeling in bioinformatics
… multiple genes are prevalent in nature and many diseases falls into this category. High-throughput sequencing and high-performance computing provides a basis to understand quantitative phenotypes. However, finding a statistical approach correctly model the phenotypes remain a challenging problem. …
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Characterizing Autism and Schizophrenia Using PRISM and Deep Learning
… spectrum disorder (ASD) are two life-altering neurological diseases whose neurobiological bases are not yet well understood. This thesis explores the phenotypical expression of autism and schizophrenia at the synapse level by applying deep learning to multiplexed immunofluorescence data. Deep …
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Untersuchungen zur differenzialdiagnostischen Bedeutung des IgG-Index und Albuminquotienten bei neurologisch erkrankten Hunden
… for the differential diagnosis of dogs with neurological diseases In the present study the benefit of IgG index and albumin quotient for the differential diagnosis in dogs with neurological diseases was investigated. The question whether the determination of these two parameters is a …
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A stochastic tractography system and applications
… hypothesize that the pathologies of some neurological diseases are associated with neuroanatomical abnormalities. Diffusion Tensor Imaging (DTI) and stochastic tractography allow us to investigate white matter architecture non-invasively through measurements of water self diffusion …
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Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue
… in excitable cells and are involved in numerous neurological diseases such as epilepsy, neuropathic pain, and cancer. Although approved drugs targeting Nav channels are available, they lack isoform selectivity, leading to unwanted side effects. Protein-protein interactions regulate Nav channel …
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Microinvasive probes for the longitudinal interrogation of neural dynamics
… human patients to help monitor and treat certain neurological diseases. Existing electrochemical probes experience signal degradation and have not been reported to remain viable after 4 months of implantation. Chronic inflammatory and foreign body responses due to large implanted device size and …
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Organisation of Neurosurgical Care in Bulgaria. Comparative Analysis // Организация на неврохирургичната помощ в България – сравнителен анализ
The severity of neurological diseases requiring surgical treatment and the limited capacity for neurosurgical care have become increasingly important in recent decades. It is estimated that an additional 23,300 neurosurgeons are needed to meet the burden of existing cases worldwide. Initiatives to …
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Understanding the role of cholinergic tone in the pedunculopontine tegmental nucleus
… of novel treatments for the symptoms of neurological diseases such as PD and PSP, which show degeneration of PPT neurons (Hirsch et al. 1987).
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Conformational Dynamics of the Glutamate Receptors via single Molecule Förster Resonance Energy Transfer
… transport across the membrane. In a number of neurological diseases, genetic variants can cause mutations that disrupt the balance between fast binding response and desensitization resulting in over- or under- signaling in affected cells. Herein it describes the use of single molecule Förster …
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UNDERSTANDING THE INFLUENCE OF TDP-43 LOSS-OF-FUNCTION ON NEUROTROPHIN SIGNALLING
… signalling, soluble Sortilin contributes to neurological diseases associated with TDP-43 dysfunction.
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