Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Neurokinin"”.
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… while TT mice did not. Using an FDA-approved neurokinin-1 receptor (NK1R) antagonist, aprepitant, we confirmed our previous findings that substance P (SP) is a key mediator of enhanced resistance to pneumonia. Blocking NK1R showed that mTBI-induced release of SP augments pulmonary neutrophil …
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Kisspeptin and neurokinin B in the regulation of the human hypothalamic-pituitary-gonadal axis
Background: Hypothalamic kisspeptin and neurokinin B (NKB) are central regulators of GnRH and thus gonadotropin (LH and FSH) secretion. Men and women with loss-of-function mutations in NKB-kisspeptin pathway show hypogonadotropic pubertal delay with reduced GnRH/LH pulsatility. Studies in patients …
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The Role of Neurokinin B in the Regulation of the Preovulatory LH Surge in Ewes
… E2 feedback pathway, including those containing neurokinin B (NKB) and kisspeptin.;Kisspeptin has been identified as a potent stimulator of LH secretion in a variety of species. GnRH neurons express the kisspeptin receptor (Kiss1r), indicating that kisspeptin can directly stimulate GnRH …
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Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury
Tachykinins and neurokinin receptors are implicated in the neurogenic inflammation (NI) during acute pancreatitis (AP). The effects of neurokinin receptor antagonists on caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and …
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Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Feline asthma, a chronic respiratory condition, results cough and/or episodic respiratory distress induced by airway hyperresponsiveness (AHR), airway eosinophilia, and airway remodeling. Homeostasis in the lung is partially …
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Intrinsic Properties and Neuromodulator Regulation of Neuronal Excitability of Intralaminar Thalamic Neurons
… arousal states. I also tested the actions of neurokinins on parafascicular nucleus neurons excitability. Substance P, neurokinin A, and neurokinin B strongly depolarized the majority of neurons tested via a decreased potassium conductance. The neurokinins can alter the excitability of …
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Sampling strategies for characterization of neuropeptides using mass spectrometry and functional implications into cell-cell signaling
… in the SON while angiotensin I, somatostatin-14, neurokinin B, galanin, and vasoactive-intestinal peptide (VIP) were detected in the SCN only. Lists of peptides were generated from both brain regions for comparison of the peptidome of SON and SCN nuclei. Moving from analysis of magnocellular …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
… 5-HT2C receptor, Melanocortin 4 receptor and Neurokinin 1 receptor respectively). COMBI-SVMs were compared to other VS methods in varies testing sets (e.g. MDDR and PubChem databases). They showed comparable dual-inhibitor yields, moderate to good target selectivity in misidentifying …
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Charakterisierung von Calcium-Transienten in Astrozyten der ventralen respiratorischen Gruppe
… Calcium-Freisetzung, die durch 5-HT2a-, Neurokinin-1- und TRH-Rezeptoren vermittelt wird, besteht somit die Möglichkeit, dass Astrozyten auf eine aktivitätsabhängige Ausschüttung dieser für das respiratorische System wichtigen Neuromodulatoren reagieren und so Einfluss auf die neuronale …
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Conformational modeling of neurokinins: Proposed bio-active conformations for different receptor subtypes
The conformations of selective analogues of neurokinins, which share a common C-terminal sequence of Phe-X-Val-Gly-Leu-Met-NH$\sb2$ (where X may be Phe or Val), have been analyzed using Monte Carlo (MC) and high temperature molecular dynamics (MD) techniques. A qualitative model for binding at the …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… substantiate this, we targeted the SP receptor, neurokinin 1, through ablation or inhibition. This led to a reversal of allergen-induced sneezing, tuft cell expansion, and eosinophilia, thereby emphasizing the critical role of SP and its receptor in Type 2 immunity. Based on our findings, we put …
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The role of Substance P and its signaling pathways in central sensitization
… stimuli. After release, substance P binds with neurokinin-1 (NK-1) receptors, which are abundantly expressed in the superficial layers of the dorsal horn. The first part of this study investigates the change in release of SP in the dorsal horn following intradermal injection of capsaicin and …
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The role of substance P in experimental intracerebral haemorrhage.
… brain injury. Inhibiting the main SP receptor (neurokinin-1 (NK1)) reduces oedema and improves functional outcome in both settings. As this thesis details, we hypothesised that SP plays a similarly deleterious role following intracerebral haemorrhage (ICH). We further hypothesised that the …
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Characterisation of substance P and transient receptor potential melastatin channel messenger RNA and protein expression in acute and chronic neurological disorders.
… attenuated with the administration of an NK-1 (neurokinin-1, SP receptor) antagonist. In addition, studies using a rat model of PD have similarly established a putative role for SP in this disease process. Transient receptor potential melastatin (TRPM) channels are a diverse family of ion …
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Spinal cord plasticity in peripheral inflammatory pain
… understood. However, it is known that lamina I neurokinin 1 receptor expressing (NK1R+) spinal cord output neurons are crucial for the manifestation of inflammatory pain. There is also evidence that the afferent input to and the postsynaptic response of these neurons may be altered in …
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Preeclampsia: The Roles of Acute Inflammation and Intrauterine Stress
… peptide and known pathogenic factor of PE, Neurokinin B (NKB), is phosphocholinated. This post-translational phosphocholination is thought to increase stability and binding of NKB to its Gq coupled receptor, NK3R. It is thought that this post-translational modification is bound by CRP …
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The Role of Substance P in Opioid Induced Reward
Chronic pain affects approximately 100 million Americans. Opioids are the mainstay therapy for the treatment of chronic pain. While physicians and patients alike are apprehensive about using opioids due to their side effects including respiratory depression and addiction, 259 million opioid …
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Spinothalamic tract neurons in laminae I, III and IV of the rat: a retrograde neuronal tracing study
… III and IV of rat spinal cord that express the neurokinin 1 receptor (NK1r) and have prominent dorsal dendrites that enter the superficial laminae. A substantial body of evidence points to the involvement of this population of cells in processing various types of noxious stimulus. Neurons of …
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Effects of Neurotrophic Factors on Osteoblast Growth and Differentiation
<p>Recent evidence suggests that bone metabolism may be influenced by the innervation of skeletal tissues. Innervation of skeletal tissues might directly influence bone volume by the release or secretion of osteogenic growth factors in the form of neuropeptides. These neuropeptides could act …