Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 288 for “"Neuroinflammation"”.
-
Neuroinflammation, Glutamate Regulation and Memory
Neuroinflammation and excessive glutamatergic signaling have deleterious effects in the brain, are mutually promoting, and play a role in the onset and progression of neurodegenerative diseases. It was my goal to better understand the relationship between neuroinflammation, glutamate dysregulation …
-
Modulating Neuroinflammation with Porous Templated Scaffolds
Neuroelectronic interfaces can restore mobility and independence for patients with neurological conditions such as spinal cord injury, stroke, or limb loss. However, unstable neural recording performance remains unresolved. Via the foreign body reaction, macrophages and glial cells develop a “glial …
-
Profiling neuroinflammation in amyotrophic lateral sclerosis
… this hypothesis by comprehensively profiling neuroinflammation in ALS, particularly in C9-ALS-FTSD with validation in other ALS cohorts (i.e., sporadic ALS-FTSD, SOD1-ALS). METHODS: High-throughput immunohistochemistry, digital pathology analysis, and random forest modelling were employed to …
-
Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… and maintenance of eTreg cells.</p> <p>Neuroinflammation is also a feature of neurogenerative diseases, but the underlying cellular mechanisms that limit inflammation in neurodegenerative diseases are largely unknown. In Chapter 5, using single cell RNA-sequencing (scRNA-seq) of immune …
-
The Role of Neuroinflammation in Alzheimer's Disease
Neuroinflammation is believed to play a key role in Alzheimer’s disease, as evidenced by recent genome wide association studies highlighting several risk genes associated with the immune response. Misfolded and aggregated proteins bind to pattern recognising receptors on glial cells in the brain, …
-
Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
… target detrimental and beneficial mechanisms of neuroinflammation, respectively, and may offer a safe and effective option with longterm benefits for the Hl-injured infant.</p>
-
Utilizing Toxoplasma gondii To Understand Neuron-Specific Neuroinflammation
Toxoplasma gondii infects up to one third of the world’s population. The parasite can persist for the life of the host by hiding in neurons in the Central Nervous System (CNS). It was thought that neurons permitted this chronic infection due to a lack of innate immune capabilities including …
-
Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
… might be a promising agent for preventing neuroinflammation and neuronal cell death mediated by activated microglia and consequently, attenuating age-associated cognitive decline.
-
Investigating the protective effects of farnesol formations against neuroinflammation
… that there is a correlation between reduced neuroinflammation and EAE severity observed in the context of FOL protection. We compared the progression of EAE in MOG35-55 immunized female C57BL/6 mice treated orally with FOL (100 mg/kg/daily) emulsified in corn oil, versus vehicle-treated and …
-
Epigenetic regulation of neuroinflammation in the aged mouse brain
… of the brain, are key players in regulating neuroinflammation. They function as the primary immune surveillance, provide the first host defense by secreting factors such as cytokines and chemokines, and carry out specific central nervous system functions such as synaptic pruning and secretion …
-
Pathobiology of neuroinflammation and basal ganglia circuitry in Parkinson’s Disease
… and genetic studies support roles for neuroinflammation in the progression of PD. Two types of cells that play a critical role in regulating neuroinflammation are microglia and astrocytes, which are activated in the basal ganglia of PD patients. Studies within this dissertation …
-
Th17 Cell Pathogenicity Promoted by Integrin α3 During Autoimmune Neuroinflammation
<p>Autoimmune diseases are caused by dysregulated immune responses against self. Multiple sclerosis (MS) is one such autoimmune disease in which the central nervous system (CNS) is affected by chronic inflammation, and Th17 cells are critical mediators of disease pathogenesis. While targeting …
-
Apolipoprotein E alters the association of neuroinflammation with Alzheimer's disease
Alzheimer’s disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors. The apolipoprotein E (APOE) allele e4 imparts a dramatic increase in the risk of developing Alzheimer’s disease, but the exact mechanism of this relationship is unknown. The e4 allele …
-
Influenza infection induces neuroinflammation and impacts hippocampal structure and function
… cells. Taken together, these data suggest that neuroinflammation and changes in hippocampal structural plasticity may underlie cognitive dysfunction associated with influenza infection. The loss of immunomodulatory factors important for neuron-microglia interactions, along with reduced …
-
Mechanisms of cytosolic DNA sensing and neuroinflammation in ataxia-telangiectasia
… microglial cytosolic DNA sensing as a driver of neuroinflammation and provides a rationale for exploring the therapeutic potential of STING inhibition in disorders attributed to genome instability in the CNS.
-
The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… available for traumatic brain injuries (TBI). Neuroinflammation is a key aspect of the secondary injury process, but remains poorly understood. Recent work has shown that Type I Interferons, inflammatory cytokines typically produced in response to viral infection, are present in the post-mortem …
-
Guanabenz Reduces Hyperactivity and Neuroinflammation Caused by Latent Toxoplasmosis in Mice
… hyperactivity correlates with a decrease in neuroinflammation instead of cyst counts, suggesting that some behavioral changes arise from host responses to infection rather than a parasite-driven process.
-
Neuroinflammation and Cognitive Impairment in the Aged: Implications for Nutritional Intervention
Aged mice exhibit a heightened central inflammatory cytokine response, as well as prolonged hippocampal-dependent cognitive deficits, compared to adults when administered lipopolysaccharide (LPS) to mimic a peripheral infection. The excessive production of inflammatory cytokines such as interleukin …
-
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… in depth in microglial cells during CNS neuroinflammation. Using primary microglial culture prepared from cPLA2 knockout mice, we found that oxidative and nitrosative stress responses were significantly attenuated in cPLA2 knockout mice as compared with wildtype control. The same …
Page 1 of 15