Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Neuroimmunology"”.
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Converging Pathways: Neuroimmunology of Tauopathy and Mild Traumatic Brain Injury
Age-related neurodegenerative diseases impact over 60 million people worldwide with the number steadily increasing each year as the global population ages. Despite years of research and many clinical trials, no therapeutic has proven efficacious at addressing disease progression. The vast …
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LncRNA Nostrill Facilitates Neuronal Antiviral Responses by Promoting NFkB-Mediated Irf7 Transcription
Differences in antiviral and inflammatory gene expression influence viral clearance in the central nervous system. Persistent antiviral and inflammatory gene expression are associated with neurodegeneration and the development of neurodiseases. Long non-coding RNAs (LncRNAs) are key cell-specific …
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Extracellular adenosine as a novel neuroimmune modulator
Adenosine is a pleotropic purine nucleoside with actions ranging from neurotransmission to immunomodulation. Pathologic processes that trigger cellular stress and damage also cause significant increases in local and systemic concentrations of adenosine. Coinciding with elevation in adenosine is an …
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Microbiota-gut-immune-brain communication across the lifespan
While the exploration of the gut microbiome in health and disease evolves, the implications of the microorganisms that inhabit the gut for host brain health also multiply. As we grow up and grow old, the gut microbiota along with the host physiological systems, undergoes significant remodelling. …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
The meninges have long been accepted as purely structural, protecting the central nervous system (CNS). Similarly, the choroid plexus (CP) was thought to only produce cerebrospinal fluid. Advances have dispelled these limited views, and the meninges and CP are now known as critical sites of immune …
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Novel Tools for Investigating Microglia Cellular Turnover Kinetics and Microglia-CD4 T Cell Interaction
SUMMARY Under homeostatic conditions microglia maintain a tightly-controlled population size, contributing to 5-12% of cellular tissue in the mouse brain, depending on brain region. Following injury and under inflammatory conditions microglia undergo microgliosis, a rapid expansion in number and …
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Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
Facial nerve axotomy (FNA) in immunodeficient mice causes significantly more facial motoneuron (FMN) loss relative to wild type (WT), indicating that the immune system is neuroprotective. Further studies reveal that both CD4+ T cells and interleukin 10 (IL-10) act centrally to promote neuronal …
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Neuronal Regulation of the Innate Immune Response in Caenorhabditis elegans
<p>The innate immune system is the front line of host defense against microbial infections, but its rapid and uncontrolled activation elicits microbicidal mechanisms that have deleterious effects. Increasing evidence indicates that the metazoan nervous system, which responds to stimuli originating …
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
<p>Glioblastoma is an aggressive primary brain malignancy harboring a tumor microenvironment that is mostly devoid of T cell effector infiltration but is dominated by immune suppressive microglia, macrophages, and myeloid-derived suppresser cells. These innate immune cells display impaired …
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
Pneumonia is the second leading cause of disability-adjusted life-years lost worldwide and the eighth leading cause of death in the United States. Traumatic brain injury (TBI) patients have classically been considered immunosuppressed, but recent research reported that mild head trauma patients …
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Retinoid X Receptor as a Mediator of Post Stroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Macrophages
<p>After stroke, microglia (MG) and blood-derived macrophages, together (MF), clear dead cells and cellular debris in the infarcted brain through phagocytosis. However, the phagocytic capability of MF declines with age. Age-related changes in MF phenotype also include overactive inflammatory …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and schizophrenia, are rising in prevalence, yet their etiology and underlying mechanisms remain largely elusive. Epidemiological studies implicate influenza A virus (IAV) infection during pregnancy as a risk factor for …
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
Multiple sclerosis (MS), the most prevalent inflammatory autoimmune disorder affecting the central nervous system (CNS), results in the deterioration of myelin sheaths and neuronal injury. For reasons that remain unclear, the majority of patients eventually enter a disease stage termed progressive …
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Mild Traumatic Brain Injury with Associated Visual System Dysfunction: Investigating Histopathology, Functional Correlates, and a Novel Therapeutic Immune Modulator
<p><strong>Background</strong>. Traumatic brain injury (TBI) is a significant source of morbidity and mortality worldwide. Injuries associated with moderate to severe TBI can be profound, and have historically overshadowed the significant impact mild TBI (mTBI) can have on the lives of affected …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
Autoimmune disease is characterised by the development of abnormal immune responses directed against antigenic components of the host i.e. self-antigen. Multiple sclerosis (MS) is a chronic autoimmune, inflammatory disease directed against an unknown antigen in the central nervous system. This …