Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Neuroimmune interactions"”.
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Modelling neuroimmune interactions using organotypic slice cultures
… are suitable for the investigation of cellular interactions and neural functions in CNS-TB, and the neuronal impact of PPD warrants further investigation.
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Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
Psychological distress or physical strain lead to reduced blood flow in the intestine since other organs are prioritised. One aim of this thesis was to investigate how ischemia followed by reperfusion affects the large intestine and the enteric nervous system (ENS). To do so an experimental …
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
… cancer therapy, driven by complex, multi-scale interactions that current biomarkers often fail to capture. This dissertation introduces the Biologically Disentangled Variational Autoencoder (BDVAE)—an interpretable deep learning framework designed to uncover mechanistic drivers of ICI resistance …
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A Dual Investigation of Questions in Drug Addiction: Exploring the Role of Neuroinflammation in Opioid Withdrawal and A Novel Measure of Reward-Seeking Behavior in Rodents
… the drug addiction field by 1) investigating neuroimmune interactions as a potential mechanism in opioid withdrawal in mice as well as 2) introducing a novel behavioral test in order to expand the repertoire of tools available to researchers investigating drug or reward-seeking behaviors in …
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Mast cells affect brain physiology and behavior
… a role in regulating the stress response through interactions with neural systems. The goal of this thesis is to examine the functional role of brain mast cells using a mouse model. Mast cells are present in the mouse brain parenchyma, meninges and choroid plexus from birth throughout adulthood. A …
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Unravelling the impact of early-life nutrition on microbiota-gut-brain axis signalling
… system development, studies often overlook the interactions between these systems in critical time-windows of developmental opportunity. Given that external influences such as diet could be decisive for brain function there is a growing need for investigation of the effects of early-life …
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The Association between the Immune Proteome and Brain Function and Socioemotional Development in 5-Year-Old Children
Early childhood, especially the age of five, represents a critical developmental period of rapid brain and socioemotional development. Despite growing evidence of immune processes in brain development, most research has focused on prenatal exposure or adult populations and has examined a limited …
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miR-10b Rescues Diabetes and GI Dysmotility Associated with a Leaky Gut
… metabolic disorders and disorders of gut-brain interactions (DGBIs). In reference to the Rome IV criteria, the most common DGBIs, include functional dyspepsia (FD) and irritable bowel syndrome (IBS). Additionally, there is substantial overlap of these disorders and other specific GI motility …