Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Neuroimmune"”.
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Neuroimmune origins of behavioral disorders
… cytokine signaling, have been implicated in the neuroimmune pathogenesis of psychiatric disorders, but their role in fetal neurodevelopment during maternal infection has yet to be elucidated. Thus, the primary goal of the work presented in this dissertation is to delineate the activity of …
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The neuroimmune response to cryptococcal infection
… The aim of this study was to investigate the neuroimmune response to cryptococcal infection using a novel organotypic brain slice culture system. We treated cultured brain slices with either whole cell C. neoformans, its purified capsule (a known major virulent factor) or lipopolysaccharide …
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Modelling neuroimmune interactions using organotypic slice cultures
Tuberculosis predominantly manifests in the form of a pulmonary infection, but may spread out into other parts of the body and is then referred to as extrapulmonary tuberculosis (EPTB). One form of EPTB is an infection of the central nervous system (brain & spinal cord), CNS-TB. Although CNS-TB is …
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Extracellular adenosine as a novel neuroimmune modulator
Adenosine is a pleotropic purine nucleoside with actions ranging from neurotransmission to immunomodulation. Pathologic processes that trigger cellular stress and damage also cause significant increases in local and systemic concentrations of adenosine. Coinciding with elevation in adenosine is an …
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Neuroimmune and Developmental Mechanisms Regulating Motivational Behaviors for Opioids
… the conditions under which ventral striatal neuroimmune signaling may influence motivated behaviors for highly reinforcing opioid drugs.</p>
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Diet Modifies the Neuroimmune System by Influencing Macrophage Activation
… state of macrophages. During activation of the neuroimmune system, antigen presenting cells, such as macrophages, produce cytokines that mediate communication of the peripheral immune status to the brain. This cytokine network establishes a bi-directional communication between the innate immune …
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MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction
In addition to high affinity IgE receptor, human mast cells (MCs) express a newly identified receptor known as Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse ortholog MrgprB2). This receptor is predominantly expressed on only one subtype of MCs and it can be activated by a diverse group …
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Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
Psychological distress or physical strain lead to reduced blood flow in the intestine since other organs are prioritised. One aim of this thesis was to investigate how ischemia followed by reperfusion affects the large intestine and the enteric nervous system (ENS). To do so an experimental …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
… of organotypic brain slice cultures in studying neuroimmune responses in diseases of an inflammatory nature such as NCC.
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
… nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic homeostasis. …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… crucial role for peripheral plasmin in mediating neuroimmune cell activation and could provide a link to systemic inflammatory risk factors that are known to be associated with the development of AD and other neurological disorders.</p>
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Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy.
Codeine is the most widely consumed opioid analgesic worldwide. It relies upon partial metabolism to morphine to elicit analgesic effects. Paradoxically, the pain-reliever morphine has previously been linked to states of increased pain sensitivity; such as medication overuse headache and …
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Psychoneuroimmune Implications of Non-Infectious Neuroimmune System Activation and the Impact of Type 2 Diabetes
… speeds recovery from lipopolysaccharide-induced neuroimmune system activation, while only vanadyl sulfate is effective in the db/db mouse model of type 2 diabetes, (2) acute hypoxia activates the IL-1beta arm of the neuroimmune system, which is exacerbated by type 2 diabetes, and (3) acute …
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Behavioral change in response to low-grade non-infectious stimuli: findings and potential neuroimmune mechanisms
… known that sickness behavior is a consequence of neuroimmune activation. Neuroimmunity serves as a bridge between the peripheral immune system and the central nervous system, acting to signal bi-directionally both centrally and humorally between these two systems. Proinflammatory cytokines, most …
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Type 2 Diabetes Impairs Interleukin-4 Function in Macrophages and Amplifies the Brain-Based Neuroimmune Response
… may play a critical role in disrupting the neuroimmune response. This literature review focuses on neuroimmune implications of type 2 diabetes. Chapters 2 through 4 establish that (1) multiple mechanisms are in place to counter-regulate insulin signaling at the level of IRS, including …
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Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial dysfunction. In the present thesis, gene and environment (GxE) interactions were …
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Investigating the role of interleukin-6 in neuronal dysfunction in the mdx mouse model of Duchenne muscular dystrophy
… consolidation of memories and can be modified by neuroimmune cytokines, such as IL-6. The aim of this programme of research was to investigate the possible contribution of the neuroimmune molecule, IL-6 in cognitive impairment associated with loss of the structural protein, dystrophin. Initially, …
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An Examination of the Long-lasting Effects of Lipopolysaccharide-induced Sepsis on Cognitive and Affective Behaviour in Mice
… upregulated at two months post-treatment. Other neuroimmune factors were also affected in the post-septic hippocampus and amygdala such as neural precursor cell production and the production of proteins important to long-term potentiation. In order to investigate whether pharmacological …
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Role of the IKKβ/NF-κB pathway in alcoholism
Pro-inflammatory neuroimmune signaling pathways are implicated in the acute and chronic effects of alcohol exposure. Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, transcriptome meta-analysis in rodents, and drinking models in mice …
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The Impact of Impaired Cyclooxygenase-2 Activity on Mouse Brain Development: A Focus on Sex Differences
… changes in the expression of various neuroimmune markers in the brain during development. Further investigations also suggested that distinct subtypes of astrocytes may be dysregulated in male and female COX-2 knockin mice, with males exhibiting an increased prevalence of neurotoxic A1 …
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