Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Neurogranin"”.
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Role of Neurogranin In The Regulation of Calcium Binding to Calmodulin
<p><strong>Role of Neurogranin in the regulation of calcium binding to Calmodulin</strong></p> <p><strong></strong>Anuja Chandrasekar, B.S</p> <p>Advisor: M. Neal Waxham, Ph.D</p> <p>The overall goal of my project was to gain a quantitative understanding of how the interaction between two proteins …
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Investigating the negative regulatory role of neurogranin in IgE-mediated mast cell activation
… (CaM)-dependent phosphatase, calcineurin. Neurogranin is a protein that regulates Ca2+-mediated signaling pathways by binding and sequestering of CaM, subsequently acting as a critical suppressor of calcineurin phosphatase activity. Neurogranin was previously thought to exist exclusively in …
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The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation
… in these processes have not been elucidated. Neurogranin, a small protein that regulates calcium-dependent signaling, is poised to modulate both memory and synaptic plasticity. This thesis aims to provide insights into the molecular underpinnings mediating context memory formation in the …
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Molecular mechanisms of synaptic plasticity
… levels and propagates downstream signaling. Neurogranin is a neuron-specific protein that binds to calmodulin and regulates the availability of calmodulin in the postsynaptic compartments of excitatory neurons. Dysregulation of neurogranin has been reported to cause altered synaptic …
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Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
… Additionally, schizophrenia-associated protein neurogranin overexpression in V1 disrupts juvenile ocular dominance plasticity. Finally, we evaluate SRP in two models of ASDs associated with excitatory/ inhibitory imbalance: Rett syndrome (RTT) and tuberous sclerosis complex (TSC). Surprisingly, …
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Sex-Differences in Early-Onset Alzheimer's Disease
… relative to men. In CSF, EOAD women had higher neurogranin, tTau, pTau181, and VILIP1. EOnonAD women had higher plasma GFAP. In CN participants, women showed higher CSF SNAP25, whereas men showed a trend toward higher plasma pTau231. APOE ε4 status did not influence plasma or CSF biomarker …
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Effects of ammonium perchlorate exposure on the thyroid function and the expression of thyroid-responsive genes in Japanese quail embryos and post hatch chicks
… 2 deiodinase (D2) in the brain and liver, RC3/neurogranin mRNA level in the brain and Spot 14 mRNA level in the liver. Maternal perchlorate exposure led to embryonic hypothyroidism, demonstrated by thyroid hypertrophy and very low embryonic thyroidal TH storage. Embryonic hypothyroidism …
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Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
… CSF biomarkers of synaptic degeneration (neurogranin) and microglial activation (YKL-40) in healthy controls, patients with mild cognitive impairment and patients with common dementias. We found the former to be selectively increased in AD dementia, whereas the latter was increased in both …