Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Neurogenic niche"”.
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The Impact of Chronic Morphine on Adult Hippocampal Progenitor Cells and the Neurogenic Niche
… progenitor cells by altering the hippocampal neurogenic niche. I first examined a time course of morphine's effect on the progenitor cell cycle, cell death and immature SGZ neurons. I found that S phase cycling cells were vulnerable to morphine at early time points with a concurrent increase …
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A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells
… types and molecular signals necessary for this neurogenic niche were poorly understood. Here, I first demonstrate that astrocyte-like cells in the SVZ (type B cells) can self-renew and differentiate into mature brain cells. This data contributed to the identification of type B cells as the SVZ …
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EPH-B and Ephrin-B Signaling in Migration and Proliferation of Stem Cells
… and polarity of progenitor cells in the neurogenic niche of the DG. Ephrin-B3 acts as a ligand to regulate some aspects of EphB1 activity in the DG. I also show that the EphB2 receptor tyrosine kinase is critical for normal formation of a specific region of the DG known as the lateral …
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Comparative functional analysis of the atypical Notch ligands DLK1 and DLK2 in vertebrate development
… selectively loses its imprint in the postnatal neurogenic niche by an unknown mechanism [78]. Possessing both secreted and membrane-tethered isoforms[212, 211], DLK1 plays critical roles in a wide range of developmental processes and is implicated in several diseases, including obesity and …
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Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
… of using in vivo models to study the SVZ neurogenic niche and compel examination of the H3K27me3 catalyzing enzyme EZH2. In the future, the role of EZH2 will be determined by EZH2 conditional knockout and overexpression models, using stereotaxic injections of novel Cre protein and …
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Brain regeneration in a hypoxic-ischemic mouse model
… signaling were also significantly increased in neurogenic niche following HI insult. At last, many numbers of neural stem cell was observed in injured cortex and differentiated to neuronal and glial cells in late phage. This recovery mechanism is not yet fully understood, but for the targeting …
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Investigating the role of cell-autonomous ROS status in the regulation of hippocampal neural precursor cells in adult mice
… results in enhanced proliferation within the neurogenic niche. However, mechanistic insights into the maintenance and regulation of quiescence and the responsiveness of the NPCs to acute physical activity, as a form of adaptive neurogenesis, are yet to be elucidated. In my doctoral studies, we …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
… of the dentate gyrus and changes in the neurogenic niche during this time have not been well-studied. Using a well-characterized transgenic mouse that labels early neural progenitor cells with green fluorescent protein (GFP), we created a developmental profile of the dentate gyrus from …
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Epigenetic Regulation of Neurogenesis in Non-Demented Humans with Alzheimer’s Disease Neuropathology
… human subjects showed relative decreases in neurogenic capacity. Meanwhile those with histopathology but without cognitive decline demonstrated a significantly enhanced capacity for neurogenesis, in spite of the usually deleterious accumulations associated with the disease. These individuals …
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Characterization of Cu-rich aggregates in neurogenic niches of the rodent brain by X-ray fluorescence microscopy
… rats and mice. As the subventricular zone is a neurogenic niche in the adult brain, the hippocampal dentate gyrus and rostral migratory stream were also examined to see if these aggregates were present. It is shown that rats, but not mice, have Cu accumulations in the rostral migratory stream …
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Role of the atypical Notch ligand Dlk2, and it’s relationship with Dlk1 in mammalian neurogenesis
… brain, neurogenesis persists in two active niches, the ventricular-subventricular zone (V-SVZ) lining the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. These niches remain as NSC reservoirs throughout life, ensuring continual neurogenesis. Notch …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… found to be restricted to limited regions called neurogenic niches [2]. These neurogenic niches provide microenvironments for the NSCs survival, proliferation and neural differentiation. However, in adult human brain the presence of active NSC niches and the generation of new neurons after birth …