Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Neurogenic inflammation"”.
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Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury
… and neurokinin receptors are implicated in the neurogenic inflammation (NI) during acute pancreatitis (AP). The effects of neurokinin receptor antagonists on caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and associated lung …
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MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction
… to drug-induced pseudoallergic reactions, neurogenic inflammation and pain. However, there is a controversy regarding its role on rocuronium-induced hypersensitivity. Furthermore, the molecular mechanisms underlying MRGPRX2 regulation remain largely unknown. In this dissertation, we first …
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Exploration of Platelet and Mast Cell Communication: A Study of Membrane Lipids, Asthma, and Inflammation
… diseases including allergic asthma and neurogenic inflammation, respectively. Chapter Seven aims to state the importance of understanding the cell line you are using since variations in response to allergens are noted between commonly used mast cell models (rat basophilic leukocytes cell …
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Study of cellular mechanisms of inflammation and the involvement of mast cells in disease
… investigating the cellular signaling networks in inflammation. From an analytical perspective, the inflammatory response presents several technical challenges. The inherent complexity of the immune system makes unraveling the pathogenesis of inflammatory disease a particularly challenging …
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Characterising the role of substance P in acute ischaemic stroke.
… profile. This thesis characterises the role of neurogenic inflammation and the neuropeptide, substance P (SP), in mediating the development of blood brain barrier breakdown, cerebral oedema and resultant functional deficits following stroke, using a rodent model of reversible cerebral ischaemia. …
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The role of Substance P in chronic traumatic encephalopathy
… is a neuropeptide involved in the process of neurogenic inflammation, which has been shown previously to be involved in many processes within the brain following traumatic brain injury (TBI) including blood brain barrier disruption and development of oedema. Significantly increased levels of …
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Mise en évidence du rôle physiologique de la chimiokine CCL2 dans la neurotransmission nociceptive au niveau spinal
… mediators. It also reduced peripheral inflammation by preventing peripheral transport of SP. We then translated our findings in a model of arthritic pain, closer to the clinical reality of patients with rheumatoid arthritis. Spinal administration of INCB3344 had similar analgesic …
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Role of Slit2 in Reducing Complications after Surgical Brain Injury
… Blood brain barrier (BBB) disruption and neuroinflammation are major pathophysiological consequences after neurosurgical injury. Blood brain barrier dysfunction leads to increased influx of water and plasma proteins as well as peripheral immune cell infiltration into the brain parenchyma that …