Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Neurofunctional"”.
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Neurofunctional Characterization of the At-Risk Mental State for Psychosis
… described in this dissertation are aimed at a neurofunctional characterization of the at-risk mental state in three primary domains: reward-anticipation, hippocampus-dependent learning, and stress-reactivity. Individuals at-risk for psychosis and age-matched healthy volunteers underwent …
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Working memory and neuroplasticity in older people: a behavioural and neurofunctional approach
Working memory training (WMT) has been used to promote neuroplasticity in older people and tDCS has been proposed to boost WMT effects. Nevertheless, there is not robust evidence of WMT effectiveness and the few studies assessing the combination of tDCS with WMT used cognitive tasks as endpoints. …
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NEUROFUNCTIONAL DEFICITS DURING DECISION-MAKING AND AFFECTIVE PROCESSING IN CHRONIC MARIJUANA USERS
Marijuana is the most frequently used illegal drug in the country with medicinal and recreational use increasing. The present series of studies was designed to examine functional brain activity associated with altered decision-making and affective or emotional processing in long-term chronic …
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Neurostructural, Neurofunctional, and Neurocognitive Correlates of Cannabis Use in Adolescents with Bipolar Disorder
… This thesis examines the neurostructural, neurofunctional, and neurocognitive correlates of cannabis use in adolescent BD. The over-arching hypothesis was that cannabis use in adolescents with BD would be associated with brain structure, brain function, and neurocognition. Structural and …
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The neurofunctional correlates of sentence processing: focus on difficulties of morphosyntactic processing and thematic role assignment in aphasia
… but not morphosyntactic foils. Therefore, the neurofunctional correlates emerging from the meta-analysis and the review may offer a biased and/or partial view. As a first attempt at overcoming these limitations, a lesion study on native speakers of Italian with post-left stroke aphasia was …
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Multimodal Investigation of Neurobiological Alterations in the At Risk Mental State and First Episode of Psychosis
… the extent to which neuroanatomical and neurofunctional alterations previously reported in patients with chronic schizophrenia represent neurobiological markers of vulnerability to psychosis or are specifically associated with the onset of the disease. To this purpose, I have applied a …
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The effects of tetrahydrobiopterin (BH4) treatement on nonverbal working memory-related brain activations and connectivity in individuals with phenylketonuria
… results suggest that PKU-related disruptions in neurofunctional activation and connectivity are pervasive. However, these disruptions may be sensitive to BH4 treatment, as evidenced by normalized activation and connectivity patterns in several brain regions, including dorsolateral PFC and FFA.
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Differences in brain architecture during long-term recovery following mild traumatic brain injury
… following mTBI may be due to some form of neurofunctional reorganization. To this end, we examined abnormalities in resting state functional connectivity and structure (volume, thickness, and fractional anisotropy) in two groups of mTBI – those with 1-10 yrs. time-post injury (mTBI1-10), …
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Investigating the At-Risk Mental State and First Episode Psychosis using Genetic, Cogntive and Multi-modal Neuroimaging Data: A Multivariate Support Vector Machine Study
… be characterised by genetic, neuroanatomical, neurofunctional and cognitive alterations similar to those observed in ChSz, albeit less severe. With respect to neuroanatomy, and neurofunction moreover, they suggest such changes may be both subtle, and spatially diffuse. The achievement of only …
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The Neurocognitive Sequelae of Chronic Traumatic Brain Injury and the Utility of Treatment with Methylphenidate
… connectivity, and MPh-driven behavioural-neurofunctional relationships. I found that patients with TBI have deficits in accuracy and reaction time, together with differences in activity and connectivity, and some of these deficits are ameliorated with a single dose of MPh. These were in …
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Structures and functions of the post-mortem brain: an experimental evaluation of the residual properties of fixed neural tissues
… serves to challenge the assumption of neurofunctional loss after death by employing modern technology to observe alternative mechanisms by which information can be processed by fixed, post-mortem neural tissues. The central aim of the thesis was to measure periodic, electric potential …
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The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… in stroke. Caspase-9 inhibition provided neurofunctional protection and established caspase-6 as its downstream target. Caspase-6 is an effector caspase and a member of the intrinsic death pathway that has never been implicated in stroke until now. Coincidentally, we discovered that …
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Interactions between numbers and space : neurobehavioural evidence from children and adults
… (Study 1) and children (Study 2) as well as in a neurofunctional investigation using high-resolution functional magnetic resonance imaging (Study 3). In Study 1 the comparison of numerical distances was influenced by the spatial alignment of the numbers (responses were facilitated on congruent …
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The Neurocognitive Dynamics Underlying Loss of Control in Alcohol Misuse and Addiction
… the addiction trajectory- and its corresponding neurofunctional impairments- leveraging three interrelated methodologies: Cognitive Task Development: <br>Fundamental to this research is the development, optimisation, and validation of novel cognitive paradigms designed to quantify cognitive …