Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Neurofibromatosis Type 2"”.
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… sheath tumors similar to patients with a form of Neurofibromatosis. Neurofibromatosis types 1 and 2 are inherited cancer disorders resulting from the inactivation of their specific tumor suppressor genes, NF1 and NF2, respectively. Inactivation of the NF2 gene, results in the development of …
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A cancer screen in zebrafish identifies many ribosomal proteins as haploinsufficient tumor suppressors
… in which the known human tumor suppressor gene, neurofibromatosis type 2 (NF2), was mutated. This validated the screening approach, as well as confirmed the human relevance of the zebrafish system in the study of cancer. Surprisingly, all of the remaining tumor-prone lines identified in the …
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Characterization of the two major merlin isoforms and merlin regulation of YAP
… Deletion or loss-of-function of NF2 leads to neurofibromatosis type 2, a disease characterized by the formation of multiple benign tumors of the nervous system. In addition to the genetic disorder, loss of merlin expression has been found in sporadically occurring schwannomas and meningiomas, …
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Analysis of the function of the Nf2 tumor suppressor protein, Merlin
The Neurofibromatosis type 2 tumor suppressor gene (NF2) is mutated in inherited and sporadically occurring central nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal domain to members of the band 4.1 family of membrane-cytoskeletal …
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The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
… sporadically or as part of the genetic condition Neurofibromatosis type 2 (NF2) and cause significant morbidity. The current treatment options are restricted to surgery and radiotherapy, which are invasive and may cause further tumour development. The activity of both the E3 ubiquitin ligase …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… is responsible for the development of all Neurofibromatosis Type 2 (NF2)-related tumours including schwannomas, meningiomas and ependymomas. These tumours can also occur spontaneously in non-NF2 patients. The only available treatments for this group of tumours are surgery and …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… thus design more suitable therapeutic options. Neurofibromatosis Type 2 (NF2) is one of the most commonly inactivated tumor suppressor genes in mesothelioma. The downstream signaling pathways that may be disrupted as a result of this inactivation are not entirely understood. Conversely, the …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… thus design more suitable therapeutic options. Neurofibromatosis Type 2 (NF2) is one of the most commonly inactivated tumor suppressor genes in mesothelioma. The downstream signaling pathways that may be disrupted as a result of this inactivation are not entirely understood. Conversely, the …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… for clinically-symptomatic tumors is surgery. Neurofibromatosis type 2 (NF2) is an autosomal dominant inherited cancer predisposition syndrome, caused by a germline mutation in the NF2 tumor suppressor gene, in which affected individuals develop spinal cord (SC) ependymomas. In this …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… loss is the major cause of a hereditary disease Neurofibromatosis type 2 (NF2) characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this group of tumours are not fully …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
Neurofibromatosis type 2 (NF2) is an autosomal dominant inherited condition that predisposes individuals to develop multiple nervous system tumours, primarily schwannoma, meningioma and ependymoma. NF2 is characterised by loss of the tumour suppressor protein Merlin, caused by bi-allelic mutations …
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
Neurofibromatosis type 2 (NF2) is an inherited, multiple tumour disease caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is …
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STUDY OF PHYSIO-PATHOLOGICAL MECHANISMS AT THE BASE OF SCHWANNOMA DEVELOPMENT
Schwannomas are the most common type of peripheral nerve tumor. Usually, schwannomas are benign, well‐circumscribed tumors clinging to peripheral nerves, consisting of a clonal population of Schwann cells (SCs), which often undergo cystic and degenerative changes. Most cases are sporadic, however, …
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Outcomes of Auditory Brainstem Implantation in Adults with Postlingual Deafness: A Systematic Review
<p><strong>Objective:</strong>The purpose of this investigation is to conduct a systematic review of the long-term speech-recognition outcomes of ABIs in postlingually deafened adults, and to compare outcomes of ABIs in adults with NF2/tumors to adults without NF2.<strong> </strong></p> …