Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Neurofibromatosis 1"”.
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A NOVEL, RAS-INDEPENDENT ROLE FOR NF1 IN MICROTUBULE DYNAMICS AND DAMAGE REPAIR DICTATES SENSITIVITY TO T-DM1 IN HER2 POSITIVE BREAST CANCER.
Neurofibromatosis 1 (NF1) is among the first tumor suppressor genes to be cloned. Loss-of-function (LoF) mutations in NF1 are at the basis of the onco-developmental syndrome Neurofibromatosis type 1 and are frequently found at the somatic level across multiple tumors. In breast cancer, NF1 LoF has …
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Inferential Methods to Find Differences in Population of Graphical Models with Applications to Functional Connectomics
… relevant network differences in synesthesia, neurofibromatosis-1 and autism spectrum disorders.
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On the Multiscale, Mechanical Behaviors of Mineralized Bone
… der vorliegenden Arbeit werden Schnurri (Shn3), Neurofibromatosis-1 (NF1), und α-HS Glycoprotein (Ahsg) Maus-Modelle untersucht, bei denen der Prozess der Mineralisation gestört ist. Auf der Materialebene zeigen sich keine signifikanten Unterschiede in den Eigenschaften, was zum Schluss führt …
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Molecular Genetic Analysis of Tumor Cells and Developmenet of RNA Interferance Therpy in Neurofibromatosis Type1(NF1)
Neurofibromatosis 1 (NF1) is the most common familial cancer syndrome in humans, with a birth incidence of 1:3500 and a prevalence of 1:4000-.1:5000 in the general population. NF1 is transmitted in an autosomal dominant manner, with about 30-50% of NF1 patients representing de novo germline …
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ADHD and Medical Correlates of Bullying of Pediatric Neurofibromatosis Patients
Neurofibromatosis Type 1 (NF1) is an autosomal dominant disorder that involves nervous system tumor growth, and it is one of the most frequently occurring genetic disorders. NF1 is a multisystem disease with a complex phenotype. Given the range in severity of presentation in NF1, research has shown …
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Mechanistic and Therapeutic Insights for Epigenetic Regulation in Cancer Development
… that develop sporadically or in patients with Neurofibromatosis type 1 (NF1). Effective treatment options are lacking, and MPNSTs are typically fatal. To gain insights into MPNST pathogenesis, we utilized a novel MPNST mouse model that allowed us to study the evolution of these tumors at the …