Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Neurofibrillary tangle"”.
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Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
PART I 1 Ⅰ. INTRODUCTION 2 A. Basal forebrain of mammals 2 B. Neuron types in the basal forebrain 2 C. Alzheimer’s disease 3 D. Normal functions of tau protein 4 E. Structure and Posttranslational Modifications of the Tau Protein 5 F. Distribution of tau phosphorylation sites and NFT …
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Investigation of BACE1 as a stress-induced regulator of neuronal metabolism
… the brain once hallmark amyloid plaque and neurofibrillary tangle pathologies have presented. However their appearance is extremely end stage and to date, any therapeutic interventions aimed at alleviating them having failed to halt symptoms progression. It may therefore be beneficial to …
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Characterizing Medial Temporal Lobe Neurodegeneration Due To Tau Pathology In Alzheimer's Disease Using Postmortem Imaging
Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s Disease (AD). Using in vivo structural magnetic resonance image (MRI) analysis, volumetric change in the MTL caused …
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Neuronal Protection by a Novel C-terminal Hsp90 Modulator
… the P301L Tau mutation and develop aberrant Tau tangles as well as cognitive impairments, we assessed KU-32 treatment in vivo. The JNPL3 mice were treated with 20 mg/kg of KU-32 or with 12.5% Captisol® (vehicle) five times a week for six months. Immunohistochemical studies indicated significant …