Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Neuroepithelial cells"”.
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The development and evolution of vertebrate oxygen-sensing cells
Oxygen-sensing cells release neurotransmitters, including serotonin, in response to hypoxia in the blood or surrounding air/water. This stimulates the glossopharyngeal and/or vagal nerves, triggering increased ventilation via the respiratory reflex. In the adult, they are located in the carotid …
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Investigating the role of ZEB2 in the establishment of neuroepithelial architecture and axon tract formation
… mouse embryos ZEB2 is expressed in telencephalic neuroepithelial cells (NECs) before the switch to radial glia (RGCs). By establishing a human embryonic stem cell (hESC) model of ZEB2 heterozygous loss-of-function we show that this gene modulates the changes in cell-cell contacts at the transition …
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The role of integrin mediated adhesion and signaling during Xenopus retinal development
… at the termini of F-actin filaments in XR1 cells. These proteins display spatial and temporal expression patterns, which are related with specific morphologies during retinal development. The similar and differential expression patterns suggest that focal adhesion proteins are involved in …
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Characterising molecular and cellular mechanisms of human brain evolution using brain organoids
… of gain-of-function in a subset of radial glial cells. We find that the transcriptional regulator, AUTS2, has a dramatic effect on cell fate and tissue architecture. By generating organoids with loss-of-function of C-terminal-containing AUTS2 isoforms, we find neurogenesis is premature, which may …
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Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells
… the hippocampus from quiescent adult neural stem cells. Traditionally neural stem cells were cultured as neurospheres, a heterogeneous agglomeration of neural cells at various stages of differentiation. This heterogeneity prevented accurate quantitative analysis. In 2008 Sun et al produced the …
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CHARACTERISATION OF Y-BOX PROTEIN 3 (MSY3) IN THE DEVELOPING MURINE CENTRAL NERVOUS SYSTEM
… (CNS) arise from a common pool of multipotent neuroepithelial progenitor cells lining the walls of the neural tube. Initially, neuroepithelial cells undergo symmetric proliferative divisions, thereby expanding the progenitor pool and determining the size of brain compartments. At the onset of …
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… of the nervous system. The number of embryonic neuroepithelial cells (NECs) is regulated by programmed cell death when NECs are substantially proliferated by growth factors(GFs). The extrinsic factors such as epidermal growth factor (EGF), basic fibroblast growth factor(bFGF), as well as …
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Comparative hypoxia responses and oxygen sensing in galaxiid fishes
… to hypoxia are mediated by oxygen sensing neuroepithelial cells (NECs) and by the transcription protein hypoxia inducible factor 1 (HIF-1), the effect of inescapable moderate hypoxia at 5 mg L-1 dissolved oxygen concentration (without access to the water surface) on these parameters was …
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Διερεύνηση του μοριακού μηχανισμού δράσης της Geminin στα πρώιμα εμβρυϊκά βλαστικά νευρικά κύτταρα
Ο φλοιός αποτελεί την εξωτερική στιβάδα του εγκεφάλου των θηλαστικών και είναι μία δομή που χαρακτηρίζεται από υψηλή κυτταρική ετερογένεια και πλούσια συνδεσιμότητα. Η ανάπτυξη του φλοιού αποτελεί μία διαδικασία που αρχίζει κατά τα αρχικά εμβρυϊκά στάδια και βασίζεται στη δημιουργία διακριτών …