Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 229 for “"Neurodegenerative disorders"”.
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Genetic Characterisation of Neurodegenerative disorders
… increasing number of elderly are affected with neurodegenerative diseases, including the subjects of the studies in this work, Alzheimer's disease (AD), Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). On strong evidence that several genes may …
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ML-assisted therapeutics for neurodegenerative disorders
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Cannabinoids: A Novel Treatment Strategy for Retinal Neurodegenerative Disorders
<p>Synthetic and naturally occurring cannabinoids are known to decrease intraocular pressure (IOP). Glaucomatous damage to the retina and optic nerve progresses even after therapy to maintain normal intraocular pressure (IOP). Topical application of cannabinoids decreases IOP while not affecting …
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Transcriptomic studies of protein homeostasis perturbations in neurodegenerative disorders
… was then extended to a broader family of neurodegenerative disorders associated with the aggregation of tau protein, which is a hallmark of AD and other diseases, in order to underline the importance of the balance between key molecular mechanisms in combatting the disease progression. The …
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Alterations of High-Energy Brain Metabolites Across Multiple Neurodegenerative Disorders
… to be manipulated by acute and chronic neurodegenerative disorders such as stroke, traumatic brain injury, and epilepsy. I hypothesized that cerebral energy levels are decreased in my model systems for Alzheimer's disease, Autism, Down syndrome, and HIV-1 dementia and that dietary …
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Factors affecting teleneuropsychological assessment and patient satisfaction in neurodegenerative disorders
Εισαγωγή: Η εξειδικευμένη φροντίδα ενδέχεται να καταστεί περισσότερο προσβάσιμη μέσω νευροψυχολογικής αξιολόγησης που πραγματοποιείται με τηλεδιάσκεψη σε άτομα που διαμένουν σε απομακρυσμένες περιοχές, όπου η πρόσβαση σε αυτές τις υπηρεσίες είναι περιορισμένη. Δεδομένου ότι η δοκιμασία Montreal …
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Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
… evidence supports a role for oxidative stress in neurodegenerative disorders such as AD and PD. AGEs have been shown to contribute towards oxidative damage and chronic inflammation, whereby activated microglia secrete cytokines and free radicals, including nitric oxide (NO). Roles proposed for NO …
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An Analysis of Mitochondrial DNA in Rett Syndrome and Other Neurodegenerative Disorders
… progresses, attention is now focusing on neurodegenerative diseases. Rett Syndrome (RS), a progressive neurodegenerative disease with predominantly female cases, demonstrates morphologic mitochondrial changes, mitochondrial enzyme deficiencies and maternal inheritance (characteristic of …
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CROSS-DISEASE ANALYSIS OF MOLECULAR AND CELLULAR MECHANISMS IN KIF5A-ASSOCIATED NEURODEGENERATIVE DISORDERS
… the three KIF5A domains are linked to distinct neurodegenerative or neurodevelopmental disorders. Missense and nonsense mutations in KIF5A motor and stalk domains are associated with hereditary spastic paraplegia type 10 (SPG10) and axonal Charcot-Marie-Tooth disease (CMT), while frameshifts in …
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The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders
Neurodegenerative disorders are a group of age-related conditions resulting in neuronal cell death and protein accumulation. It is estimated that around 5-10% of these cases are genetically mediated. Most commonly this is by pathogenic single nuclear variants (SNVs), though combinations of rare …
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Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders
… and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile plaques and may cause a self-propagating inflammatory process that contributes to the disease processes of AD; Somatostatin …
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Ensemble of classifiers based data fusion of EEG and MRI for diagnosis of neurodegenerative disorders
<p>The prevalence of Alzheimer's disease (AD), Parkinson's disease (PD), and mild cognitive impairment (MCI) are rising at an alarming rate as the average age of the population increases, especially in developing nations. The efficacy of the new medical treatments critically depends on the ability …
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Uncertainty-Aware Ensembling in Multi-Modal AI and its Applications in Digital Health for Neurodegenerative Disorders
Common neurodegenerative disorders such as Alzheimer's dementia and Parkinson's disease are increasingly recognised as leading causes of death and disability with debilitating symptoms such as progressive cognitive decline, communication breakdown, motor dysfunction and accompanying psychiatric …
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An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disorders.
… is closely associated with more than fifty human disorders, including Alzheimer's and Parkinson's diseases, all of which are currently incurable and many represent a major threat to human life. The mechanism of protein aggregation is subject to extensive studies. The damaging effects associated …
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Responsive, multimodal imaging agents for MRI: advancing the detection of metals and oxidized species implicated in neurodegenerative disorders
The successful development of responsive, multimodal imaging agents required a bottom-up approach starting with the nature of the iron oxide nanoparticles. Thee relaxivity of the nanoparticles was found to be dependent on the total anisotropy of the particles themselves, which is in turn a function …
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X-ray Spectroscopic Studies of Model Compounds With Relevance to Nickel Superoxide Dismutase, Nitrile Hydratase and Copper Related Neurodegenerative Disorders
X-ray absorption spectroscopy (XAS) is a technique that is very useful for gaining structural and coordination information of compounds that do not crystallize. In this research a variety of bioinorganic systems were studied, each consisting of a transition metal compound that was …
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Development and utilization of Luminex biomarker assays for diagnosis and monitoring of neurodegenerative disease
A common pathological feature of various neurodegenerative disorders is the accumulation of misfolded proteins in the brain. Neurodegenerative disorders associated with protein misfolding include Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), fronto-temporal …
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Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS.
… discovery of ageing, neuroinflammation and neurodegenerative disorders. The n-3 fatty acids EPA and DPA are thought to exhibit a range of neuroprotective effects many of which are mediated through production of such lipid mediators. The aims of this study were to evaluate the effects of n-3 …
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