Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 517 for “"Neurodegenerative diseases"”.
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Intravital diagnostics of neurodegenerative diseases
Prionopatie, taktiež nazývané transmisívne spongiformné encefalopatie (TSE), a synukleínopatie predstavujú skupinu neurodegeneratívnych ochorení, ktoré sú asociované s akumuláciou nesprávne zložených proteínov (prión a α-synukleín) prevažne v centrálnom nervovom systéme. Kvôli absencii spoľahlivého …
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Pathogenesis of Neurodegenerative Diseases via Templated Recruitment
A common feature of many neurodegenerative diseases is the deposition of filamentous protein aggregates in the central nervous system (CNS), including neurofibrillary tangles (NFTs) composed of tau, and Lewy bodies (LBs) consisting of α-synuclein (α-syn), which are the hallmark lesions of …
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Investigating neurodegenerative diseases with small molecule modulators
… of the mechanisms underlying cell death in neurodegenerative diseases has proven difficult, due to the complex and interconnected architecture of the nervous system as well as the often pleiotropic nature of these diseases. Cell culture models of neurodegenerative diseases, although seldom …
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miRNA expressione profiles in retinal neurodegenerative diseases
… una moltitudine di patologie, incluse patologie neurodegenerative. L'identificazione di un pattern di espressione del profilo di miRNA potrebbe essere utilizzato come un metodo innovativo per la scoperta di nuovi biomarcatori e lo sviluppo di nuovi target farmacologici nell'uomo. Lo scopo della …
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De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
This work sought to characterize novel and existing radioligands, assessing their utility and effectiveness for positron emission tomography (PET) imaging of neurodegeneration. Three proteins were targeted: 1) colony stimulating factor-1 receptor (CSF-1R); 2) glycogen synthase kinase-3 (GSK-3); and …
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Functional and Pathophysiological-morphological Correlates of Neurodegenerative Diseases
This doctoral thesis pictures neurodegenerative diseases as a multilevel process, describes various correlates on each pathophysiological level, and presents selected correlates in Huntington's disease and mitochondrial membrane protein-associated neurodegeneration (MPAN). It uses various …
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
Glucosylceramide (GlcCer) is one of the simplest glycosphingolipids (GSLs) synthesized at the cytosolic face of cis-Golgi and translocated to the plasma membrane and organelle lumen. The glucocerebrosidases degrade GlcCer in the cytosol and lysosome. GlcCer has been suggested to be an activator of …
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Modelling neurodegenerative diseases in human iPSC-derived neurons
… is a pathology shared by a varied class of diseases, and many of the mutations that are known to cause such diseases have been linked to protein aggregation and autophagy dysfunction. Improvements to gene editing and neuronal differentiation strategies have enabled the derivation of in vitro …
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Microwave sensing and imaging for early detection of neurodegenerative diseases
L'abstract è presente nell'allegato / the abstract is in the attachment
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Statistical Learning for Gene Expression Biomarker Detection in Neurodegenerative Diseases
… approaches are used to detect biomarkers for neurodegenerative diseases (NDs). NDs are becoming increasingly prevalent as populations age, making understanding of disease and identification of biomarkers progressively important for facilitating early diagnosis and the screening of individuals …
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Mitochondrial protein SFXN3 as a novel target in neurodegenerative diseases
Neurodegenerative diseases are a group of heterogeneous disorders consisting of the progressive degeneration of the nervous system. Despite major scientific advances, most neurodegenerative diseases have no cure. This results in a significant emotional, social, and economic burden across the globe. …
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Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
… filaments are the pathological hallmark of >20 neurodegenerative diseases including Alzheimer's disease, Pick's disease, and progressive supranuclear palsy. In the adult human brain, six isoforms of tau are expressed that differ by presence or absence of the second of the four semiconserved …
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On the Structure and Function of Tau Assemblies in Neurodegenerative Diseases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Sleep in Neurodegenerative Diseases: An Integrated Approach to Diagnosis and Monitoring
L'abstract è presente nell'allegato / the abstract is in the attachment
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Early Detection of Neurodegenerative Diseases from Bio-Signals: A Machine Learning Approach
… which resulted in the prevalence of age-related diseases like Alzheimer’s and dementia. The occurrence of such diseases continues to increase and ultimately the cost of caring for these groups will become unsustainable. Addressing this issue has reached a critical point and failing to provide a …
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Processing biomedical images for the study of treatments related to neurodegenerative diseases
… of neuronal cell morphology and function in neurodegenerative disease processes is essential in order to develop suitable treatments. In fact, studies such as the quantification of either synapses or the neuronal density are instrumental in measuring the evolution and the behaviour of neurons …
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NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
The main, underlying cause of neurodegenerative disease is the progressive loss of neuronal structure or function, whereby central and/or peripheral nervous system circuitry is severely and irreversibly damaged, resulting in the manifestation of clinical symptoms and signs. Neurodegenerative …
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Overexpression of Heat Shock Factor 1 Protects against Pathological Proteins in Neurodegenerative Diseases
A classical feature of neurodegenerative disorders is the accumulation of protein aggregates, such as TAR DNA/RNA binding protein (TDP-43) and superoxide dismutase 1 (SOD1), which lead to neuronal dysfunction and loss. Therefore, molecules that maintain protein homeostasis may be beneficial …
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Single-conformation spectroscopy of hydrogen bonding networks: Solvation, synthetic foldamers, and neurodegenerative diseases
… forming sidechain—is intimately involved with neurodegenerative diseases such as Huntington’s disease. Single-conformation studies help reveal the delicate interplay between three different types of hydrogen bonds within the molecule: backbone-backbone, sidechain-backbone, and …
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