Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 319 for “"Neurodegenerative disease"”.
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Detecting Multimodal Behaviors for Neurodegenerative Disease
Neurodegenerative diseases such as Parkinson’s and Alzheimer’s are incurable and affect millions of people worldwide. Early diagnosis is critical for improving quality of life for patients. Current methods rely on the use of tests administered and evaluated by clinicians. The digital Symbol Digit …
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Investigating Ageing of Neurodegenerative Disease Relevant Protein Condensates
… between dysfunctional proteins condensates and neurodegenerative disease pathogenesis complements the current research. Protein condensates often become pathological when their physical properties change, from a liquid state to a more gel-like or solid-like state. This process is referred to as …
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The spread of pathological assemblies in neurodegenerative disease
Neurodegenerative diseases represent a significant burden on global health. Their incidence and prevalence are projected to increase dramatically over the next few decades. Yet no effective disease-modifying treatments exist, partly owing to our incomplete understanding of pathogenesis. It is known …
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Quantitative analysis of proteotoxicity associated with neurodegenerative disease
Neurodegenerative diseases are a costly burden, both economically and in terms of human suffering. A common feature of neurodegenerative diseases is that they stem from problems with protein folding, but the underlying biology that leads to neuron death is not well understood. Due to this lack of …
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Molecular mechanisms of axonal transport impairment in C9orf72-associated neurodegenerative disease
Understanding the etiology of neurodegenerative diseases and developing therapeutic strategies to tackle these conditions has become an increasingly important challenge for biomedical research. Neurons, with their extended axons and dendrites, rely on the integrity of the microtubule cytoskeleton …
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Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease
… immune pathways. In humans, Alzheimer’s disease pathology is significantly associated with immune activation in excitatory neurons. Spatial transcriptomics reveal that regions of CK-p25 brain tissue dense with DSB-bearing neurons harbor signatures of inflammatory microglia, which is …
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Interactions of Alpha-Synuclein With Phospholipids: Implications for Physiology and Neurodegenerative Disease
… represent an early event in the development of neurodegenerative disease.
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Protein -Protein Interactions of Synucleins: Implications for Normal Function and Neurodegenerative Disease
… has been implicated in learning and memory and neurodegenerative disease, thereby influencing the entire spectrum of brain function. The data presented here addresses the normal function of the synucleins as it relates to protein-protein interactions. Immunoprecipitation assays reveal that AS …
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Using cannabidiol and trazodone to treat protein misfolding neurodegenerative disease in C. elegans
Alzheimer's disease is one of the most common neurodegenerative disorders and is typically characterized by the accumulation of the misfolded proteins Amyloid-Beta (Aβ1-42) and/or hyperphosphorylation of Tau (p-Tau). Despite the lack of a cure for the disease, it is well known that targeting …
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Study of the etiology of neurolathyrism, a human neurodegenerative disease with nutritional causes
… initiates the development of neurolathyrism, a disease characterized by neurodegeneration, which results in a spastic paraparesis. The neuro-excitatory amino acid β-N-oxalyl-L-α,β-diaminopropionic acid (L-β-ODAP) present in grass pea was proposed as the cause of the disease. Although the …
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Investigating speech technology for monitoring disease progression in the context of neurodegenerative disease
… most frequent cause of dementia is Alzheimer’s Disease (AD), which is known to start silently up to 20 years before observable symptoms appear. Therefore, interdisciplinary research efforts are focusing on unravelling disease progression and developing strategies for secondary prevention (i.e. …
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Neuroprotective effect of mesenchymal stem cells in neurodegenerative disease : focusing on Parkinsonian disease
… neuroprotective effect of hMSCs in Parkinson’s disease, we extended our investigations into other parkinsonian disease in addition to properties of hMSCs on blood-brain barrier. . PART A. Human mesenchymal stem cells exerts neuroprotection in an animal model of double lesion-induced multiple …
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Understanding neurodegenerative disease-relevant molecular effects of perturbagens using a multi-omics approach
The complex etiology of neurodegenerative diseases is not fully understood, and the characterization of cellular pathways that are dysfunctional in these diseases is key for therapeutic development. Chemical and genetic perturbagens can probe cellular pathways to shed insight about both disease …
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A Study of alpha-Synuclein, Parkin and TDP-43 ; Proteins Implicated in Neurodegenerative Disease.
… kDa neuronal protein associated with Parkinson's disease (PD) and related disorders. Aggregated protein inclusions called Lewy bodies found in the brain in PD contain alphaS. Rare inherited forms of early-onset PD are caused by autosomal dominant mutations in alphaS or by autosomal recessive …
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Development and utilization of Luminex biomarker assays for diagnosis and monitoring of neurodegenerative disease
A common pathological feature of various neurodegenerative disorders is the accumulation of misfolded proteins in the brain. Neurodegenerative disorders associated with protein misfolding include Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), fronto-temporal …
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… that are genetically linked to Parkinson's disease, together with alpha -synuclein being the major component in Lewy bodies, has generated extensive interest in alpha -synuclein as a key component in neurodegenerative diseases. In recent years modeling this disease in transgenic mice and …
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Structural Elucidation of the Interaction Between Neurodegenerative Disease-Related Tau Protein with Model Lipid Membranes
… fibrillar aggregates is connected with over 20 neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized in part by misfolding, aggregation and deposition of the microtubule associated tau protein into neurofibrillary tangles (NFTs). However, two questions remain: What …
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Biophysical and Therapeutic Approaches to Neurodegenerative Disease: Insights From Lysosomal and RNA-Binding Protein Systems
Neurodegenerative diseases arise from progressive failures in the cellular systems that maintain protein and RNA homeostasis, yet how distinct molecular defects contribute to the disease pathogenesis is incompletely understood. This dissertation investigates two complementary arms of this network: …
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Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations
… had been previously diagnosed with Alzheimer’s Disease (AD), could be used to investigate the role of this parasite in AD. Secondly to investigate T. gondii infection in naturally infected wood mice (Apodemus sylvaticus) populations and the parasite’s role in the expression of a range of key …
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