Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Neurodegenerative conditions"”.
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Stigma, perceived control and health-related quality of life for individuals experiencing Parkinson’s disease
… of psychological wellbeing for individuals with neurodegenerative motor conditions. Section 1 describes a systematic literature review of quantitative correlates of stigma for individuals with neurodegenerative conditions, which result in visible motor differences. Five electronic databases were …
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Genetic characterisation of the Drosophila Mitochondrial Calcium Uniporter in physiological and neurodegenerative contexts
Neurodegenerative conditions such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are a growing medical and social burden for which no disease-modifying therapies exist, necessitating greater understanding of their underlying pathobiology. Mitochondrial health and calcium signalling have …
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An Applied Neurobiological Model Of Dance, Why It Matters, And How It Heals
Dance-based programs for neurodegenerative conditions such as Parkinsons and Alzheimers (PD/AD) diseases are growing, with reported benefits including physical, cognitive, and affective improvements. This is not a new phenomenon; throughout history in cultures around the world, dance has played a …
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Novel Diagnostic Approaches for Genetic and Environmental Sources of Mitochondrial Dysfunction
… cardiovascular disease, diabetes mellitus, and neurodegenerative conditions on the rise, understanding their pathogenesis is paramount to tackling this public health crisis. Current research indicates that the primary cause of these diseases is mitochondrial dysfunction in the affected patients. …
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Stretch Injury Alters Calcium Dynamics and Actin Organization in Human Astrocytes
… major public health concern, linked to long-term neurodegenerative conditions such as Alzheimer’s disease. Although neurons are often the primary focus of TBI research, growing evidence highlights the critical role of astrocytes—especially their calcium signaling dynamics—in driving post-injury …
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Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro
… neuropathological feature found in a number of neurodegenerative conditions, including Alzheimer's disease. Understanding the kinetics of this aggregate build up, how it varies across patients, and how aggregation might be influenced by intracellular pathways is critical for both a deeper …
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Exploring retinal changes in Dementia and Multiple Sclerosis
Diagnosis and monitoring progression of neurodegenerative diseases relies on the assessment of clinical symptoms such as cognitive impairment in Alzheimer`s disease (AD) and disability in Multiple Sclerosis (MS). Detection of molecular and morphological hallmarks in the brain or spinal cord is …
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Structural Dynamics and Electrostatic Properties of the VEGF and PIM-1 Oncogenic Promoter G-Quadruplexes from Polarizable Molecular Dynamics Simulations
… to a wide variety of human diseases including neurodegenerative conditions, premature aging disorders, and various cancers. Therefore, these structures have gained growing interest as the subjects of various research investigations to explore potential methods for targeting and disease …
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Frequency Interception and Manipulation Vulnerabilities in Myoelectric-Computer Interface Signal Transmission
… patients with motor impairments due to injury or neurodegenerative conditions. Neural interface research has focused on device accuracy and usability while neglecting to comprehensively assess security risks. These devices store substantial personal data that can lead to exploitation if …
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Effects of mitochondrial dysfunction on neurofilament turnover and distribution in human neuroblastoma cells
A common feature of neurodegenerative conditions including Parkinson’s disease (PD) is the presence of intracytoplasmic proteinacious inclusions. In PD these inclusions are called Lewy bodies (LBs) and contain a number of proteins including α-synuclein, ubiquitin and neurofilaments (NFs). NFs, the …
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Wireless Sub-Cellular Sized Stimulators for Minimally Invasive Deep Brain Stimulation with High Spatiotemporal Resolution
… treatment for motor disorders associated with neurodegenerative conditions such as Parkinson’s disease (PD). The DBS device, often called the “pacemaker for the brain”, utilizes surgically implanted leads with 4-8 contacts points into the targeting area. The implanted electrodes are then used …
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Providing effective memory retrieval cues through automatic structuring and augmentation of a lifelog of images
… applications vary from helping those with neurodegenerative conditions recall events from memory, to the maintenance and augmentation of extensive image collections of a tourist's trips. However, a large lifelog of images can quickly amass, with an average of 700,000 images captured each …
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Targeting and Localization of Alpha-Synuclein in Primary Neurons
… alpha-synuclein (alpha-syn) has been linked to neurodegenerative conditions such as Parkinson's disease (PD) and dementia with Lewy bodies. Previous studies have shown that alpha-syn normally undergoes delayed localization to presynaptic terminals but the key structural elements involved have …
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Modelling Early Events In Amyloid Aggregation
… from normally soluble proteins in several neurodegenerative conditions including Alzheimer’s disease. Traditionally, attention has focused on the proliferation of macroscopic quantities of biofilaments, and experimentalists have relied on bulk measurements to quantify this. By contrast, the …
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Development of Two Novel Families of Platinum(Ii) Coordination Complexes for Nucleic Acid Recognition
… in genomic regions involved in cancer, neurodegenerative conditions, bacterial infections, and viral infections. Therefore, targeting G4s using small molecule binders has rapidly grown as a field of research due to the potential therapeutic effect on a range of possible diseases. The …
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Leveraging Protein Homeostasis as a Disease-modifying Strategy
… in early in Cancer and progressively in neurodegenerative conditions. Delving deeper into specific diseases, we use protein-protein interaction data to demonstrate an intersection between Aβ and tau PNs and carry out cell-based experiments to propose this indirect connection as a …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… including neuronal loss implicated in various neurodegenerative conditions. DLK is axonally expressed and is under constant suppression under normal conditions. Although DLK is known to localize in axons and has crucial roles, the mechanisms governing DLK localization in axons remain elusive. …
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Sleep, Perivascular Spaces, and Cognition in Alzheimer's Disease and Parkinson's Disease
… and executive function, is a core component of neurodegenerative conditions, such as Alzheimer’s disease and Parkinson’s disease. Two factors that are likely related to and may contribute to these cognitive deficits are sleep changes and enlarged perivascular spaces, which are an indicator of …
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Effect of cellular factors on the generation of beta-amyloid.
… protein in the underlying pathology of human neurodegenerative conditions including Alzheimer's disease (AD), light chain amyloidosis, spongiform encephalopathies, Huntingdon's disease, Parkinson's disease, etc. AD is a progressive neurodegenerative condition responsible for dementia in the …
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Investigation into the destructive and adaptive responses of neural cells to stress
… to neuronal loss and dysfunction in many neurodegenerative and neurological disorders. This thesis is centred on better understanding the vulnerability of neurons to stress, as well as adaptive responses to these stresses. Since neurodegenerative conditions associated with Ca2+, redox and …
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