Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 612 for “"Neurodegeneration"”.
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Calcium Dyshomeostasis In Neurodegeneration
… In order to develop novel therapeutics to combat neurodegeneration, a better understanding of the molecular mechanisms underlying these diseases is needed. Neurons rely on Ca<sup>2+</sup> to mediate many of their unique functions, and aberrant Ca<sup>2+</sup> signaling has been broadly implicated …
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Exploring neurodegeneration in Ataxia-Telangiectasia
Ataxia-Telangiectasia (A-T) is a very rare autosomal recessive DNA repair disorder. The condition is characterised by a progressive neurodegenerative disorder. Cancer predisposition, immunodeficiency and respiratory disease can result in premature death. The life expectancy of a patient with A-T is …
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Models of neurodegeneration using computational approaches
Alzheimer's disease (AD), as one of the most common neurodegenerative diseases, is characterized by the loss of neuronal dysfunction and death resulting in progressive cognitive impairment. The main histopathological hallmark of AD is the accumulation and deposition of misfolded Aβ peptide as …
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
… microglial activity may be beneficial during neurodegeneration, but excessive release of pro-inflammatory cytokines and reactive oxygen/nitrogen species is a hallmark of neurodegenerative disease and can promote neurodegeneration. Additionally, microglial phagocytosis of the protein aggregates …
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A magnetic resonance approach to neurodegeneration
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1997.
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TDP-43 and its role in neurodegeneration
… of TDP-43-mediated toxicity leading to neurodegeneration and may aid in the development of pharmacological therapy for human disease.
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Glutamate Imaging of Mouse Models of Neurodegeneration
… changes in glutamate levels in mouse models of neurodegeneration using a novel magnetic resonance imaging technique, glutamate chemical exchange saturation transfer (GluCEST) imaging. Several studies were performed in three mouse models of neurodegeneration: the APP-PS1 transgenic model of …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
<p>Several studies have identified Rho family GTPases (i.e. Rho, Rac, Cdc42) as mediators of diverse critical cellular processes, such as actin cytoskeleton remodeling, gene transcription, cell-cell adhesion, and cell cycle progression. However, more recent data highlight an essential role for Rho …
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Regulation of biochemical pathways involved in neurodegeneration
… but do not prevent or slow the underlying neurodegeneration. Therefore, research into the biochemical mechanisms of AD is necessary in order to develop a better understanding of how to treat it. Misprocessing of the amyloid precursor protein (APP) in the brains of AD patients leads to …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
… The latter is a common denominator of neurodegeneration. Neurons are found to be particularly vulnerable to toxic stress from aggregation-prone proteins such as α-synuclein. Induction of heat-shock proteins (HSPs), such as through activated heat shock transcription factor 1 (HSF1) via …
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ROLE OF LIPOCALIN 2 IN KAINATE-INDUCED NEURODEGENERATION
… the role of LCN2 in kainate (KA)-induced neurodegeneration. Intracerebroventricular injection of KA in rats induces neuronal loss in the hippocampal formation. Therefore, the KA model was used as a neurodegeneration model to elucidate the role of LCN2 in neurodegeneration in the …
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Synthetic Investigation of Natural Products Causing Dopaminergic Neurodegeneration
The terrestrial organisms Streptomyces venezuelae and Rhaponticum repens produce toxic secondary metabolites that likely function as chemical deterrents. The polyketide SV-6 from S. venezuelae and the sesquiterpene lactone repin from R. repens both produce dose-dependent and selective degeneration …
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Screen for Suppressors and Enhancers of Excitotoxic Neurodegeneration
… for genes whose mutation can alter the extent of neurodegeneration. We are using two approaches to systematically knock-down/modify <em>C. elegans </em>genes and test their involvement in exicitotoxic neurodegeneration: a) We are developing sensitive strains that will allow us to use an RNAi …
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The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… stroke, runaway apoptosis contributes to stroke neurodegeneration and neurological decline for days to weeks after disease onset. Cysteine-ASPartic proteASEs (caspases) are key mediators of apoptosis that are activated in distinct molecular pathways, but their impact in stroke is poorly defined. …
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Modelling prion-induced neurodegeneration in PrP transgenic Drosophila
… genotypes to study the process of prion-induced neurodegeneration in this model. Prion diseases are caused by the occurrence of an abnormally-folded form of PrP (PrPSc) protein that arises either from the environment as an acquired disease, from mutation in the PrP-coding gene as a genetic …
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Longitudinal Visualization of Neurodegeneration: Digital Biopsy of the Retina
… a better understanding of what changes lead to neurodegeneration is required. Due to the isolated physiology of the eye, the classical markers of inflammation are not detectable in-vivo without an invasive biopsy. The major aims of this dissertation are to explore optical methods for a digital …
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Reversal of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease
… cytokines only acts to accelerate neurodegeneration. Therapeutic antibodies can reduce the neurotoxic oligomeric form of Tau (o-Tau), but in doing so they also aggravate inflammation. Attenuating mutation of the antibody Fc region can silence inflammation but also eliminates its …
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Neurodegeneration and behavior in rodents treated with chronic methamphetamine
… and examine links between chronic meth-induced neurodegeneration and neurodegenerative disorders.
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