Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Neurocognitive disorders"”.
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Treatment of HIV associated neurocognitive disorders
… changes including HIV associated neurocognitive disorders (HAND). HAND is a spectrum of cognitive impairment, which in its most severe form cause marked interference with day-to-day functioning (HIV-associated dementia). Antiretroviral therapy (ART) has substantially reduced the …
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HIV-Associated Neurocognitive Disorders: Role of Viral Reservoirs and Lipid Dysregulation
… comorbidities, including HIV-associated neurocognitive disorders (HAND), persist in the HIV-infected population; but the mechanisms are unknown. We hypothesized that neurocognitive decline in the HIV-infected population is dependent on CNS viral reservoirs by mechanisms of damage …
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HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy
… I also investigated potential HIV-Associated Neurocognitive Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers …
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An investigation of a neuro-inflammatory profile of HIV-associated neurocognitive disorders
Background HIV-associated neurocognitive disorder (HAND) is the consequence of the effects of HIV-1 within the central nervous system (CNS). HIV-associated neurocognitive impairment differs in severity with milder forms presenting in 50% of people living with HIV (PLWH), regardless of treatment …
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The role of the astrocytic marker S100B in HIV-associated neurocognitive disorders
… are as yet no ideal biomarkers of HIV-associated neurocognitive disorders. As astrocytosis is a feature of HIV encephalitis, the marker S100β may hold promise as a biomarker of HAND. We explored associations between S100β and neurocognition in individuals with HIV in Cape Town, South Africa, …
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Unravelling the molecular mechanisms of HIV associated neurocognitive disorders through mass spectrometry-based proteomics
… dysfunction that characterises HIV associated neurocognitive disorders. While the molecular aetiology of this important HIV complication remains largely uncharacterised, HIV transactivator of transcription (HIV-Tat) has been identified as a plausible aetiological cause. Here we have used mass …
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Proteomic investigation of blood-based biomarkers for the diagnosis of HIV-associated neurocognitive disorders
… the prevalence of milder forms of HIV-associated Neurocognitive Disorders (HAND). Clinical diagnosis of such cognitive decline currently relies on neurocognitive assessments, as no definitive biochemical test exists. A point-of-care test designed for use with easily accessible samples (e.g. blood) …
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Neurocognitive disorders in young adults commencing highly active antiretroviral treatment in the Western Cape
Background: HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). It is not known whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to HAART. …
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Caregiver training to enhance care interactions with persons with neurocognitive disorders: An additive treatement study
<p>Persons with neurocognitive disorders (NCD) rely on family and friends to help them with everyday tasks, yet informal caregivers might not be aware of the need to scaffold tasks or know how to maximize the care recipients’ engagement. The current study recruited three men who were full-time …
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Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape
HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). The aim of the study was to investigate whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to …
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Validation of the CAT rapid: a smartphone screening tool for HIV-associated neurocognitive disorders in South Africa
… not suitable for the detection of HIV-associated neurocognitive disorders (HAND) in South Africa. Study 1 of the current thesis aimed to establish construct validity of a new screening tool, the Cognitive Assessment Tool-Rapid(CAT-Rapid), in a sample of cognitively healthy South African …
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The relationship between neurocognitive disorders, prospective memory impairment and white matter damage in clade C HIV-positive subjects
AIMS: To examine the relationship between prospective memory, cognitive function and Diffusion tensor imaging (DTI)/ White matter integrity of human immunodeficiency virus (HIV) positive individuals in the Western Cape. We hypothesize that: 1. Individuals infected with HIV will exhibit …
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Screening for HIV-associated neurocognitive disorders in perinatally infected youth: Validation of the CAT-rapid version 2 screening tool
… Tool Rapid v2 tool in screening for all forms of neurocognitive impairment in a sample of youth living with HIV in Cape Town, South Africa. Design: We analysed the existing dataset of the neuro sub-study which was nested within the larger CTAAC study (Cape Town Adolescent Antiretroviral Cohort). …
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The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
… different forms of HIV-1 associated neurocognitive disorders (HAND) still persist and affect about half of the HIV infected population. The importance of HIV-1 accessory protein Vpr has been well established in the pathology of AIDS in the peripheral and central nervous system. …
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CANNABINOIDS DELTA-9-TETRAHYDROCANNABINOL (THC) AND CP55,940 ABLATE SPECIFIC CHEMOKINE AND CYTOKINE INFLAMMATORY RESPONSE IN BV-2 MOUSE MICROGLIAL CELLS ACTIVATED WITH HIV-1 PRO-INFLAMMATORY PROTEIN TAT
… immunodeficiency syndrome (AIDS), HIV-Associated Neurocognitive Disorders (HANDs) still remain a dire issue. HIV can enter the brain through infected monocytes and infect microglia, the resident macrophages within that compartment. Due to its pro-inflammatory properties, HIV regulatory protein Tat …
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Identifying Subtypes of Neurocognition using Latent Profile Analysis in Adults: A Presicion Medicine Approach
… ages, the prevalence and societal cost of neurocognitive disorders such as dementia will continue to increase. Therefore, there is a pressing need to thoroughly elucidate these disorders' characteristics and progression. Despite existing research efforts, the exploration of neurocognitive …
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The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study
… of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND), a spectrum of neurological diseases which includes HIV-associated dementia (HAD), a debilitating sUb-cortical dementia. HIV-related cognitive impairment is a primary neurological complication of HIV infection, as …
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Modeling Complex Neurological Disorders With Human Induced Pluripotent Stem Cells
The etiology of many complex neurological disorders, including schizophrenia (SZ) and HIV-Associated Neurocognitive Disorders (HAND), are still unknown, partly due to a lack of accurate models. Human-induced pluripotent stem cells (HiPSCs), which can be differentiated into any cell type and capture …
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