Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Neuro-oncology"”.
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Integrating Exercise Within Neuro-Oncology Care
Neuro-oncology patients are underserved in the field of exercise oncology. With growing evidence on the role of exercise for this patient population, there is a need to develop and evaluate accessible and tailored exercise interventions within standard supportive neuro-oncology care. The purpose of …
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Bioengineering-enhanced neurosurgical solutions
… all meant to profoundly impact the outcome of neurosurgical patients. This thesis touches upon the window of opportunity to exploit bioengineering techniques in three subspecialties of this vast discipline: neuro-oncology, radiosurgery and neuro-traumatology. After a thorough identification of …
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
… (RECIST) or the modified Response Assessment in Neuro-Oncology (RANO), primarily focus on measuring tumor size changes for treatment response assessment. However, these conventional techniques may not detect early therapy responses, as many cancer treatments initially manifest at a microscopic …
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Magnetic Resonance Spectroscopy Imaging of 2-Hydroxyglutarate in Brain Tumors at 3T and 7T In Vivo
… mutant gliomas is a significant breakthrough in neuro-oncology imaging. 2HG is the first imaging biomarker that is specific to a genetic mutation in gliomas, making the diagnosis of IDH mutant gliomas possible without biopsy. 2HG also has a significant predictive value with respect to the stage …
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Molecular and Mechanical Heterogeneity in Adult and Paediatric High-Grade Glioma
High-grade gliomas are aggressive, lethal tumours of the central nervous system with no available cure. Both adult and paediatric high-grade gliomas (HGGs) are characterized by rapid proliferation and diffuse invasion of tumour cells into the surrounding stroma. Additionally, these tumours display …
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Depression in glioma
… glioma. Researchers interested in psychological neuro-oncology could convene a meeting to guide future projects, particularly since multi-centre studies may be necessary to recruit sufficient sample sizes in future.
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VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM
… fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still …
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Characterization of brain response following cranial radiotherapy
… of microglia number had different effects on neuroanatomical outcome depending on sex. These studies provide a foundation for future research aimed at developing interventions to mitigate long-term neurocognitive deficits in survivors of pediatric cancer.
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
Glioblastoma (GBM) is an aggressive brain cancer with a near-uniformly lethal prognosis. Anti-tumoural immunity remains low due to a highly suppressive tumour microenvironment. This project set out to identify immunomodulatory proteins secreted by glioblastoma, describe the distribution of …
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
<p>Glioblastoma is an aggressive primary brain malignancy harboring a tumor microenvironment that is mostly devoid of T cell effector infiltration but is dominated by immune suppressive microglia, macrophages, and myeloid-derived suppresser cells. These innate immune cells display impaired …
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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
… significant impact on non-cancerous post-mitotic neurons. The co-application of IMT also potentiates the benefits of chemotherapy and gene therapy. We have created a robust in vivo IMT model using allograft GBM cells in Fischer rats to test the efficacy of IMT in vivo. The GBM animal studies to …
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Accelerated radiotherapy with carbogen and nicotinamide for carcinomas of the head and neck: a study on feasibility, toxicity and tumor response
Contains fulltext : mmubn000001_275417662.pdf (Publisher’s version ) (Open Access)
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Morphological, functional, and therapeutic aspects of brain tumor vasculature: an experimental study
Contains fulltext : 145677.pdf (Publisher’s version ) (Open Access)
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Network approaches to understanding the functional effects of focal brain lesions
… decade. Despite significant attention within the neuroimaging and cognitive neuroscience communities, these approaches have hitherto not been extensively explored in neurosurgery. The aim of this thesis is to investigate how the field of connectomics can contribute to understanding the effects of …
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Exploring the immunologic consequences of ATRX deficiency in glioma
<p>ATRX is a key chromatin regulator that is frequently mutated across multiple cancer types. One of the most common ATRX-mutated tumor types is the adult-type glioma, IDH-mutant, Astrocytoma. It is known that ATRX mutation leads to increases in DNA damage, replication stress, and global epigenetic …
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Characterising Heterogeneity of Glioblastoma using Multi-parametric Magnetic Resonance Imaging
A better understanding of tumour heterogeneity is central for accurate diagnosis, targeted therapy and personalised treatment of glioblastoma patients. This thesis aims to investigate whether pre-operative multi-parametric magnetic resonance imaging (MRI) can provide a useful tool for evaluating …