Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"Neurite Outgrowth"”.
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Effects of Dextromethorphan on Neurite Outgrowth and Marble Burying Behavior
… behavior, in addition to the assessment of neurite outgrowth in PC12 cells. Therefore, to test the role of DM, a sigma-1 compound, glutamate NMDA antagonist, and DM metabolite-dextrorphan were used in both MBT and a neurite outgrowth assay. Marble burying data revealed a significant decrease …
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Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
… Previous studies have shown that PKCe induces neurites in neuroblastoma cells. Here we report that treatment with cell-permeable C2-ceramide inhibits PKCe-induced neurite formation, conceivably by relocating the protein from the cytosol to the perinuclear region. Mutation of Asp-257 and Met-278 …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
… cysteines (SPARC) as a mediator of OEC-induced outgrowth in vitro. To test the contributions of SPARC to spinal cord repair after OEC transplantation, cultures of LP OECs from SPARC null and wildtype (WT) mice were transplanted into a crush of the dorsolateral funiculus. Substance P and tyrosine …
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Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
… reductase inhibitor, lovastatin, promotes neurite outgrowth in some systems and inhibits it in others (Schulz et al., 2004; Holmberg et al., 2006). Anecdotally, lovastatin also contradictorily relieves or exacerbates memory loss in Alzheimer's patients (Wagstaff et al., 2003; Sparks et al., …
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THE ROLE OF NADPH OXIDASE IN NEURITE OUTGROWTH AND ZEBRAFISH NEURODEVELOPMENT
Nicotinamide adenine dinucleotide phosphate oxidases (NOX) are a family of enzymes that produce reactive oxygen species (ROS). The first NOX enzyme was discovered in leukocytes and associated with host defense in the immune system. Subsequent findings of ROS production in non-immune cells led to …
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… Glutamate application to neurons elicited neurite inhibition and often retraction, which was abolished by kynurenic acid. Glutamate-induced neurite retraction appeared to be due, in part, to calcium influx via voltage-gated calcium channels, since application of high potassium media …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… of neurodegenerative disorders. We performed neurite outgrowth studies on cells treated with lovastatin and found statin administration increased neurite branching. Global inhibitors do not give us a good indication of what is causing the observed effect as they do not implicate how inhibiting …
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Investigation of the role of neuroserpin in neurite outgrowth and learning and memory
… Neuroserpin has been shown to play a role in neurite outgrowth but con icting results have been reported. Neuroserpin has also been proposed to play a role in learning and memory but direct evidence for such a role is lacking. e overall goals of this thesis were to further investigate a role …
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Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells
… PIP5KIα, an isoform of PIP5Kα, plays a role in neurite outgrowth. For this, I generated a stable PC12 cell line lacking PIP5KIa by microRNA (miRNA) expression, leading to decreased PtdIns(4,5)P2 level. Results show that neurite outgrowth induced by nerve growth factor (NGF) was more prominent in …
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Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… challenge for in vitro research is improving neurite outgrowth (extensibility) and directionality, which would encourage and mature the neuronal cell into a functional neuron. In this research, we develop a computational model to predict neurite extension as a function of ECM stiffness and …
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Wnt Signaling in Growth Cone Mediated Neurite Outgrowth from Spiral Ganglion Neurons in the Adult Mouse
… of cochlear implants is to stimulate and guide neurite outgrowth from spiral ganglion neurons toward electrodes to form private channels of communication between the cochlear implant and the targeted neuronal populations. To date, there has been little investigation into the roles of Wnt …
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The expression and functional analysis of neurite outgrowth inhibitors in the nervous system of Xenopus laevis
… Moreover, several proteins inhibitory to neurite growth, such as Tenascin-R (TN-R) and Nogo-A, have been identified in mammals. These proteins are associated with oligodendrocytes and myelin and are considered major inhibitory components of the CNS environment.
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Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
… for cells, as well as tropic effects to guide neurite outgrowth. Cultured neurons of the Lymnaea central nervous system (CNS) have previously been used to investigate the role of RA in neurite outgrowth and growth cone guidance. Recently however, a novel phenomenon has been identified, in which …
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Investigating the effects of aging and the neuromodulator retinoic acid on neurite outgrowth in a novel CNS organ culture
Neurite outgrowth is a critical process for nervous system regeneration following injury. However, aging impairs this process through changes in calcium handling, neurotransmitter sensitivity, and energy metabolism. In this thesis, I investigated agerelated changes in neurite outgrowth using a …
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Regulation of neuronal differentiation by activity-induced calcium influx in striatal neural precursors
… derived neurons by promoting GABA expression and neurite outgrowth that are essential steps in establishing neuronal identity and enabling neurons to form functional connections. Although excitatory activity activates CREB, its effects on neuronal differentiation are transcription and translation …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… vitro method has been standardized that measures neurite outgrowth along with cytotoxicity of test compounds in a single assay. The neurotrophin signaling pathways were interrogated with selective inhibitors of MEK1/2 (PD98059/U0126) PI3K (LY294002) and TrkA (GW441756) and phosphorylation of …
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Macrophage recruitment in DRG contributes to sensory axon regeneration after conditioning injury
… minocycline infusion reduced CI-induced neurite outgrowth in vitro and sensory axon regeneration after CI in vivo. These data suggest that macrophages play an essential role in the CI-induced axon regeneration. Macrophage conditioned media (CM) treated with cAMP did not exhibit …
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