Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Neurexin"”.
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Regulation of Oligodendrocyte differentiation through Neuroligin-Neurexin signalling
… interaction of NL and its pre-synaptic partner neurexin (NX), the developmental profile of OL cells was delayed. Conversely, enhancing the interaction accelerated the developmental profile. Evidence is also presented that glutamate receptors are potentially spatially localized to the contact …
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Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin
… has prompted the search for candidate genes. Neurexin and neuroligin, trans-synaptic ligands for each other, are two families of synaptic cell-adhesion molecules that have been linked to ASD pathogenesis. I found that three different mouse models for ASDs, the neurexin-1α deletion, the …
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Role of Neuroligin in Synapse Formation and Autism
… of a trans-synaptic complex with presynaptic neurexins. Interaction of neuroligin 1 with neurexins is regulated by alternative splicing of both neuroligin 1 (at splice site B) and of neurexins (at splice site #4). Full-length neuroligin 1 that binds only beta -neurexin more potently promotes …
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Effects of MDGA2 Reduction on Synaptic Long-Term Depression and Development in Male Mice
… excitatory synaptogenesis by inhibiting neurexin-neuroligin adhesion complexes and BDNF/TrkB signaling. Mdga2+/- mice, modeling autism-associated mutations, show increased excitatory synapse density and hyperexcitation in adulthood, resulting in altered hippocampus-dependent cognition and …
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Biophysical and Structural Studies of CNTNAP2
… interaction networks. CNTNAP2 is a member of the neurexin superfamily of synaptic cell adhesion molecules; it is localized at the juxtaparanodes of myelinated axons at the Nodes of Ranvier where it mediates interactions between neurons and ensheathing glial cells and recruits potassium channels to …
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Enzyme mediated labeling of synaptic proteins for proteomics and imaging
… identify the trans-synaptic interaction of the neurexin-neuroligin complex across the synaptic cleft, and 2) an "eraser" for LpIA based probe ligation.
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A TALE OF TWO NEUREXINS: NRX-1 AND NLR-1 FACILITATE FUNCTION OF MONOAMINE CIRCUITS AND FORAGING BEHAVIORS
… Defining the mechanisms by which SAMs, such as neurexins and Casprs, alter neural circuits and behavior can thus improve our understanding of how mutations in these genes impact behavior. I use the model system C. elegans to define how the conserved neurexin and Caspr orthologues, nrx-1 and …
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Neurologin Function in Excitatory and Inhibitory Synapses
… molecules which by binding to presynaptic neurexins (NRXs) are thought to mediate synapse formation and function. Both NLs and NRXs are discussed in the genetic correlation to Autism. Over-expression of NLs could induce the formation of synaptic contacts with axons in non-neuronal cells and …
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Brain functional connectivity and its aberrations in mouse models of autism
… contactin associated protein-like 2 (Cntnap2), a neurexin-related cell-adhesion protein, on functional connectivity. Homozygous mutations in this gene are strongly linked to autism and epilepsy in humans, and using rsfMRI, we showed that homozygous mice lacking Cntnap2 exhibit aberrant functional …
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Touching Autism Spectrum Disorder: Somatosensory Abnormalities in Shank3b and Cntnap2 Mouse Models
… codes for CASPR2, a transmembrane protein of the neurexin superfamily involved in neuron-glia interactions and clustering of potassium channels in myelinated axons. Missense mutation in CNTNAP2 is causative of cortical dysplasia-focal epilepsy syndrome (CDFE), a rare disorder characterized by …
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Functional Characterization of Neurexophilins in the Central Nervous system
… die ursprünglich als eine Komponente der alpha-Neurexine isoliert wurde, dem ersten klonierten alpha-Latrotoxinrezeptor (Petrenko et al., 1993). Vorausgehende Studien haben gezeigt, dass Nphs sezernierte Proteine mit einem relativ geringen Molekulargewicht darstellen (ca. 19 kDa deglykosyliert), …