Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Neuregulin"”.
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Axogial communication mediated by soluble neuregulin-1 and bdnf
… alternatively-spliced proteins belonging to the neuregulin1 (NRG1) gene family of growth and differentiation factors are essential for Schwann cell survival and peripheral nerve development. While membrane-bound NRG1 forms (type III) has been strongly implicated in the regulation of myelination …
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Tetracycline-dependent gene expression in cholinergic neurons of transgenic mice : a tool to study Neuregulin-1 function in vivo
… create a mouse model permitting the analysis of neuregulin-1 (NRG1) function in the adult nervous system. NRG1 is a polypeptide growth factor, which contains an ‘epidermal growth factor like’ (EGFL) domain and serves as a ligand for the erbB receptor tyrosine kinase family. Alternative splicing …
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Elucidating the role of the EGFR-family members in cell motility through the use of novel engineered bivalent ligands
… of motility is distance-dependent. Lastly, a Neuregulin-Neuregulin (NN) ligand disrupts the crosstalk between MET and Her-3 receptor to reduce hepatocyte growth factor (HGF)-induced cell motility. Based on these results, a mass spectrometry (MS)-based phosphoproteomics approach to …
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Targeting Stromal-Mediated Resistance Mechanisms in Oncogenic KRAS-Driven Pancreatic Ductal Adenocarcinoma
… the thesis demonstrates that stromal-derived Neuregulin 1 (NRG1) activates upregulated ERBB2/3 receptors on cancer cells following KRAS inhibition, establishing a critical resistance pathway. Second, optimize tissue dissociation methodology was proposed for PDAC specimens, overcoming barriers …
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… cancer cells. Engagement of HER2/HER3 with neuregulin impinges on SFKs to amplify activation of YAP in HER2+ breast cancer cells, suggesting that integrin-mediated mechanotransduction functions as a rheostat to regulate HER2 oncogenic signaling. Finally, administration of Dasatinib combined …
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Testing the efficacy of LSN2463359, a metabotropic glutamate 5 receptor positive allosteric modulator, in animal models of schizophrenia
… when the compound was administered to neuregulin-1 knockout mice, behaviors related to anxiety and social activity were also modulated to normal levels. Developing novel therapies targeting a different pathway involved with psychosis may help reduce side effects and may be beneficial in …
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Role of Laminins in the Development of the Peripheral Nervous System
… cell interactions prevent phosphorylation of β-neuregulin-1 receptors, which results in decreased cell proliferation. Postnatally, laminin-null Schwann cells exhibit reduced phosphatidylinositol 3-kinase activity and activation of caspase cascades, leading to apoptosis. Injection of a laminin …
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Role of Cuzd1 in mammary gland development and tumorigenesis
… of a subset of EGF family growth factors, neuregulin-1, epigen and epiregulin, which act via the ERBB receptors on the mammary epithelial cells. Interestingly, exposure of these cells to the EGF-like growth factors stimulated CUZD1 expression, triggered its nuclear translocation, and …
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Effects of Heregulin on Muscle: A Biochemical and Histological Analysis
… to progressive muscular dystrophy. Heregulin/neuregulin-1 (HRG), a member of the epidermal growth factor family has been shown to induce neuromuscular junction (NMJ) gene expression in vitro and improve skeletal muscle function in dystrophic mice. However, it is unclear if the HRG effects were …
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Identification and characterization of genes expressed by the midbrain dopaminergic neurons
… differentiation factor, Olf-1/Ebf, and the neuregulin receptor, ErbB4. HNF3a is expressed in the precursors of the mDA neurons at E9 and continues to be expressed in the postmitotic cells until adulthood. Analyses of the mDA neurons from mice lacking HNF3a showed that HNF3a is not required …
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Effects of diet on behavioural domains relevant to schizophrenia- a preclinical perspective
… mutant mouse models for the genetic risk factor neuregulin 1 (NRG1), the transmembrane domain Nrg1 (Nrg1 TM HET) and the Nrg1 type III (Nrg1 III tg) models, and how HFD in a maternal obesity model in C57BL/6J mice can modify schizophrenia-relevant behaviours. HFD increased body weight over time …
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Differential Regulation of Synaptic Plasticity In Epilepsy
… and one of them is the neuropeptide neuregulin (NRG). In the hippocampus, NRG is released in an activity-dependant manner and acts via ErbB4 tyrosine kinases to release dopamine (DA). In the sham condition, activation of NRG/ErbB4 signaling causes DA release which acts on D4 …
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The Functional Roles for SWI/SNF Chromatin Remodeling Complexes in Physiology and Disease
… profiling of mutant islets revealed increased Neuregulin-ERBB-NR4A signaling. Functionally, chemical inhibition of ERBB or NR4A was able to block increased regeneration associated with Arid1a loss. Together, this work defined the role of ARID1A in β-cells and provided new insights into the …
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The Nrg Growth Factors and Their Receptor ErbB4 in the Developing Brain: Delineation of Nrg3 Expression and Neuritogenesis
… that can endure into adulthood. The neuregulin (Nrg) family of growth factors (Nrg1-4) and their receptor, ErbB4, have been linked to mental illnesses considered to emerge as a result of abnormal neural development, such as schizophrenia, bipolar disorder, and depression. In the …