Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Neuraminidase"”.
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Cloning and characterization of neuraminidase from Salmonella typhimurium LT-2 and its relationship to neuraminidase from other bacteria
Bacterial neuraminidases (NANases) have been proposed to be bacterial virulence factors because of their ability to cleave sialic acid residues from host glycoconjugates. The gene encoding NANase (nanH) from Salmonella typhimurium has been cloned and its protein product purified. The purified …
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Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1
… localized in distinct subcellular compartments. Neuraminidase 1 (NEU1), the most abundant and ubiquitous of the four sialidases, functions primarily in the acidic environment of the lysosomes, but can hydrolyze substrates at the plasma membrane, at least in certain cell types. The enzyme …
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The biophysical evolution of human influenza H3N2 neuraminidase
The student, ChuYun Teo, submitted this Thesis for approval on 2022-04-05 at 15:02.
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Role of Neuraminidase-mediated Desialylation in Microglial Activation
… acid residues by enzymes called sial- idases or neuraminidases. Sialic acids are 9-carbon, negatively charged monosaccharides that normally form the terminal residue of the mammalian cells’ glycocalyx. A murine microglial cell line and primary microglia were used to study if desialylation may …
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Variation in influenza virus neuraminidase activity influences the evolutionary trajectory of hemagglutinin
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Rat Lymphocyte Surface Glycoproteins Mediating Mitogenesis by Periodate or Neuraminidase Plus Galactose Oxidase
… by the oxidative agents periodate and neuraminidase plus galactose oxidase (NGO). Lymph node cell blastogenesis induced by these oxidative agents was inhibited by reduction with borohydride or reaction with cysteine methyl ester (CME) without affecting the ability of lymph node cells …
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The Molecular Basis of Fitness and Transmissibility of Neuraminidase Inhibitor Resistant Influenza A Viruses
<p>Neuraminidase (NA) inhibitors including oral oseltamivir and inhaled zanamivir are among the first line of defense against influenza virus infection. Development of resistance to NA inhibitors is a huge drawback for limited options for the control of influenza. During the first decade of NA …
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Glycan characterizations with application in metal ion binding, the 1918 influenza virus neuraminidase formation and human receptors
… involvement in metal ion binding.</p><p>The neuraminidase (NA) of the 1918 influenza virus (H1N1) has active (tetramer) and inactive forms (monomer/dimer) with difference residing in their N-glycosylations. A structural analysis was carried out on the released N-glycans from both tetramer and …
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Initial Characterization of Attachment of Infectious Pancreatic Necrosis Virus
… cells were treated with trypsin, chymotrypsin, neuraminidase, protease, and concanavalin A (Con A) and the subsequent attachment of ³⁵S-methionine-labeled viruses assayed. IPN virus required 10 seconds to attach to CHSE cells. Significantly more viruses were adsorbed at 4°C than at 23°C or 30°C. …
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Mechanistic analysis of polymer-attached inhibitors of influenza virus and their effect on minimizing drug resistance
… inhibitor binds specifically to viral neuraminidase and inhibits both its enzymatic activity and the release of newly synthesized virions from infected cells. In contrast to monomeric ZA, however, the polymer-attached drug also synergistically inhibits virus-endosome fusion, thus …
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A Study of the Structure of Bovine Casein Micelles and the Secondary Phase of Milk Coagulation Using Immobilized Enzymes
… and pepsin) and soluble and immobilized (neuraminidase). Analysis of the reaction products gave us an indication of the surface structure of the micelle.
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Hearing loss in experimental bacterial meningitis
… derivatives of D39 deficient in pneumolysin, neuraminidase or hyaluronidase respectively. All animals developed a meningeal inflammatory response and a labyrinthitis. Hearing loss in pneumococcal meningitis was measured by recording the evoked auditory nerve compound action potential from the …
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Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
… of a previously described in vivo model of neuraminidase-induced glomerular injury is described in the rat. Information derived from the initial pilot studies has been used to formulate the hypothesis that loss of glomerular sialic acid, concomitant with functional glomerular damage, results …
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Studies on the specificities of <i>In Vivo</i> and <i>In Vitro</i> bioassays used in the potency determination of Therapeutic Erythropoietin
… Epo samples desialylated to various degrees by neuraminidase treatment. This provided proof of principle that rational manipulation of <i>in vitro</i> hioassays rendering them sensitive to a factor known to affect <i>in vivo</i> activity can allow the prediction of bioactivity without the use of …
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