Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Neural stem/progenitor cells"”.
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Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
Adult neural stem cells are now widely accepted to exist in the neurogenic regions of the subventricular zone and dentate gyrus; however there is increasing evidence to suggest that neurogenesis may also occur in other brain regions. It has been proposed that one such population of neural stem …
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Malignant Gliomas Originate From Neural Stem/Progenitor Cells and Are Maintained By Cancer Stem Cells
… with human GBM and showed a generally proneural marker gene expression profile. We also found that tumors from the same initial genetic mutations can be further divided into several subtypes. Previous studies suggested a neural stem/progenitor cell (NSC) origin for gliomas, however strict …
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Role of Sonic Hedgehog in Development of the Central Nervous System
… patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor cells. However, it has not been elucidated how Shh induces neural …
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The Role of SOX2 in Molecular Circadian Clock Regulation and Suprachiasmatic Nucleus Development
… focal point of my doctoral research, Sox2, is a stem cell gene that has been extensively studied for its function in stem cell maintenance and proliferation, cellular reprogramming, neurogenesis, and tumorigenesis. Sox2 is expressed and maintained in stem cells of different tissues, including the …
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The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
… the substantial mitochondrial demand of neural stem/progenitor cells (NSCs), which generate the majority of the brain cells during the embryonic and early postnatal periods. However, the in vivo consequences of sustained mitochondrial dysfunction during early neurogenesis remain poorly …
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Modulation of the Hippocampal Neurogenic Program by the Circadian Clock Machinery and the small GTPase, Rasd1/ Dexras1
… (SGZ) is home to a limited pool of quiescent neural stem/ progenitor cells (QNPs). These cells respond to intrinsic and extrinsic physiological changes, embark on the neurogenesis program and give rise to glutamatergic granule neurons that populate the dentate gyrus (DG). In this thesis, I …
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Regulation of Adult Neurogenesis by the ERK5 MAPK Signaling Pathway and its Functional Implications in Learning and Memory as well as Olfaction
… it may be advantageous to recruit endogenous neural stem cells to treat a variety of neurodegenerative diseases. However, despite the capability of the adult brain to continuously produce new neurons, signaling mechanisms regulating this process have not been fully elucidated. Intrinsic …
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Innate immunity in Zika Virus infection and neurogenesis deficits
… is most likely due to the high susceptibility of neural stem/progenitor cells (NS/PCs), the origin of the brain, to ZIKV. Microglia are the first and major innate immune defenders of the brain. They arise exclusively from the progenitor cells in the embryonic yolk sac (YS) and migrate to the fetal …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… contribute to tissue degeneration and limit neural regeneration and repair after injury. To optimize future therapeutic approaches, it is necessary to identify factors that regulate the early stages of these endogenous responses in order to limit their deleterious effects. In a pre-clinical …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
Neural stem/progenitor cells (NSPCs) play a crucial part in the evolutionary development of the human neocortex. During early postnatal development, NSPCs give rise to immature neurons called neuroblasts within the subventricular zone (SVZ) that utilize unique migratory streams to integrate widely …
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Characterisation of neural progenitors from the adult retina and ciliary epithelium
The mammalian central neural retina (CNR) lacks the capability to regenerate, a phenomenon retained by lower vertebrates. However, retinal stem cells have been isolated from the ciliary epithelium of the mammalian retina. Chx10 is a paired-like homeobox transcription factor gene expressed in the …
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Pten Function in Postnatal Brain Development and Tumorigenesis
… <em>Pten</em> knock-out in the nervous system showed that Pten negatively regulates self-renewal and proliferation of neural stem cells, negatively controls neuronal size, is required for proper neuronal positioning and is involved in the development and maintenance of normal function for …
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Impact of anti-viral immunity on neural stem/progenitor cell activity and implications for CNS development
… and inflammation in the central nervous system (CNS) can cause neuropathology, particularly in the prenatal and neonatal stages. Severe damage to the CNS may result from cytopathic effects of viral infection or from the immune response that may lyse virally-infected cells or release …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… the multipotent, self-renewing and proliferating neural stem/progenitor cells (NSCs) through the processes like neurogenesis and gliogenesis [1]. In the developed mammalian brain these NSCs have been found to be restricted to limited regions called neurogenic niches [2]. These neurogenic niches …
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Intracellular signaling cascades in the dopaminergic specification of fetal mesencephalic neural progenitor cells.
Neural stem (progenitor) cells (NPCs) from fetal tissue are an ideal transplantable cell source. They divide rapidly, are able to generate cells of all three neural lineages and do not divide uncontrolled once transplanted into a host organism. To obtain large quantities of cells for …