Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Neural patterning"”.
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. We further reveal an essential role of XSufu in the crosstalk of the two pathways, in which β-catenin activates Hh signalling upon overexpression of Gli1, and Gli inhibits Wnt signalling upon …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… spinal cord and suggests a novel mechanism of neural patterning.
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Testing the Role of Wnt8a Diffusion in Wnt Mediated Neural Posteriorization
… study assesses the role of diffusion of Wnt8a in patterning the anterior posterior (AP) axis of the neural plate. The vertebrate neural plate is subdivided into different morphological domains that define different functional regions. Failure to establish these morphological domains in the correct …
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Halting the neural progression of cancer
… have functions in axonal guidance and neuronal patterning. Class 3 semaphorin (SEMA3) molecules act as inhibitors of NRP receptors by preventing the activation of downstream signaling pathways involved in cytoskeletal organization and migration. Tumor-associated axonogenesis, defined as the …
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Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective
… and physiological (eg. development, neural patterning) phenotypes have emerged, much akin to a mutagenic screen. This dissertation encompasses three studies that seek to decipher the underpinnings of such rapid evolutionary diversification, investigated via the genetic variation in …
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Function and Regulation of the Conserved Wnt Target sp5 in the Vertebrate Nervous System
… function during Wnt mediated nervous system patterning is not well studied. Here we show that during neural patterning, Wnt/β-catenin signaling regulates the transcription of 3 Sp-family genes in zebrafish: sp5a, sp5-like (sp5l) and sp8b. These 3 genes are expressed in the neural plate during …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… system is an elegant model to study neural development. To reveal a specific programme for zebrafish motor axon pathfinding I established a method to selectively block motor axon pathfinding by interfering with LIM domain transcription factor signaling. LIM homeodomain proteins …
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DEVELOPMENT OF THE LARVAL PERIPHERAL NERVOUS SYSTEM IN THE ASCIDIAN CIONA INTESTINALIS: ROLE OF THE RETINOIC ACID AND FGF/WNT SIGNALLING PATHWAYS AND OF THE POU TRANSCRIPTION FACTORS.
… factors with several members that regulate the neural patterning and differentiation in both vertebrate and invertebrate embryos. C. intestinalis has only three genes coding for POU transcription factors: Ci-POU-2 Ci-POU-IV and Ci-POU-like. The gene Ci-POU-IV is specifically expressed in all …