Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Neural implants"”.
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Nanotexturisation of gold surfaces and its application to neural implants
… the interface properties of gold electrodes for neural implants. The goal was to increase the surface area without a change in geometrical footprint of the electrode with nano-fabrication tools. A process has been created that uses Nanosphere Lithography for masking layer deposition and …
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Nanofabrication of flexible thin-film bioelectronics for long-term stable neural signal recording
… for brain is a significant milestone for all neural implants. Recent studies have demonstrated that tissue-level soft and flexible materials and devices can provide such stability for neural implants. Therefore, engineering suitable materials and developing fabrication methods for soft and …
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Energy management in biomedical applications : wireless power and biosensing
… medical devices such as cardiac and neurological implants, skin patch sensors, and automatic drug delivery pumps extend and improve life by providing therapy, monitoring, and diagnostics. They ensure health and safety while promoting prevention and wellness. These devices are found in chronic and …
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Implantable Bioelectronics with Integrated Shape Actuation for Minimally Invasive Neural Interfacing
… is explored to create minimally invasive neural interfaces. Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the …
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Study of Pulse Electrochemical Micromachining using Cryogenically Treated Tungsten Microtools
… fabricated for wide range of applications from neural implants to deep micro hole drilling. Excessive wear was noticed during the application of these tools in the micromachining of difficult to machine tungsten carbide. Cryogenic treatment was performed on tungsten microtools to improve the …
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An asynchronous,low-power architecture for interleaved neural stimulation, using envelope and phase information
… the need for large D.C. blocking capacitors in neural implants to achieve highly precise charge-balanced stimulation, thus lowering the size and cost of the implant. Thus, this thesis suggests that significant performance, power and cost improvements in the current generation of cochlear …
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Design and development of a fluid actuated neural probe for chronic sensing
Neural implants have found a niche in circumventing brain dysfunction for brain-machine interfaces and in neuroscience studies for interrogation of neural tissue. The performance of implantable neural probes for chronic applications has been hampered, owing to an inflammatory immune response in the …
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Device design factors for enhancing the functionality of chronic intracortical microelectrodes
… solution for prolonging the lifetime of neural implants.</p>
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A biohybrid bridge between brain and machine: Development and application of a neural implant using iPSC-derived neuronal membranes
… for fibrotic encapsulation of implanted neural probes, leading to a gradual decline in device functionality due to the physical barrier it creates between electrodes and host tissue (at the tissue-electrode interface). However, the field has progressed from using rigid electronics to …
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Monitoring and Treating Neurological Conditions Through Focal Interfacing with the Brain
… presents the development and implementation of neural implants capable of both infusing and sampling sub-microliter volumes of fluid with exceptional spatial precision. These implants utilize micron-scale technology to minimize scarring following implantation and allow for sustained chronic …
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Tools for Monitoring and Modulating Cellular Communication
… environment of multicellular tissues. Neural and neuromuscular tissue offers both temporal and anatomical heterogeneity. Neuropathologies can arise from aberrant signaling from a single node; therefore targeting these structures directly for investigation and treatment is an attractive …
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RAPID FABRICATION OF CUSTOMIZABLE MXENE/POLYDOPAMINE (MXPDA) ELECTRODES
In the evolving field of neuroelectronics implants, several significant challenges persist. The rigidity of traditional devices often lead to substantial tissue damage and immune reactions, highlighting the urgent need for flexible, biomimetic designs that integrate more harmoniously with neural …
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Electronic implants with mechanically compliant coatings for interfacing with the nervous system
… nervous system –deep brain stimulators, cochlear implants or retinal implants. However, devices that are able to record chronically have only been used in a very limited number of pilot studies. Such recording devices would be useful in creating closed loop stimulator systems and prosthetics with …
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A biocompatible, local drug delivery platform for the chronic treatment of neurological disorders of the brain
… directly to a focal point within the implicated neural circuit. This thesis details the characterization and biocompatibility of the injectrode for the treatment of neurological disorders on chronic timescales. In vitro and in vivo infusion tests were conducted to validate the ability to deliver …
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Biohybrid Neural Interfaces: Exploring the Role of Regional Astroglia in Neuronal Integration and Functionality
Biohybrid Neural Interfaces (BNIs) offer an innovative approach to neural implantation by incorporating living neurons and traditional neural implants. This creates a dynamic cellular environment that allows for more natural interactions with host neural tissues. Given that BNIs incorporate living …
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Using electrical stimulation responses to understand cochlear implant status
Cochlear implants (CIs) are neural prostheses that improve access to sounds for patients with severe to profound sensorineural hearing loss. CIs stimulate the auditory nerve with current pulses on a multi-electrode array that is placed inside the cochlea. Success of CIs varies based on a wide range …
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Observing, Understanding, and Manipulating Biological Membranes
… about these systems, then all types of medical implants could have a customized lipid bilayer based coating that would help it to integrate perfectly with the tissue to which it is embedded. Joint replacements could have a surface that would promote the growth of osteoblast cells, a cardiac …