Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"Neural function"”.
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Divergent Criticality – A Mechanism of Neural Function for Perception and Learning
… of our experiences resonate with the efficient functioning of our brain. It proposes, that in a world of challenge and opportunity, rather than the efficient functioning of our neural resources, it is, instead, the optimising of ‘learning’ that is selected for, as an evolutionary priority. …
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The effect of experimental pain on neural function and motor learning
… to create adaptive and maladaptive changes in neural function. The first study consisted of two experiments where we determined the interactive effects of acute pain versus control (Experiment 1) and local versus remote acute pain (Experiment 2) on motor learning and sensorimotor processing and …
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Form in Darkness: Linking Visual Cortex Structure With Spontaneous Neural Function
Spontaneous neural activity within visual cortex is synchronized at varying spatial scales, from the cytoarchitecural level of individual neurons to the coarse scale of whole regions. The neural basis of this synchronicity remains ambiguous. In this thesis, we focus on the role visual experience …
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Value learning through Bellman residuals and neural function approximations in deterministic systems
… to simulator environments with state resetting functionality. Hence the algorithms cannot be applied to non-simulator environments where state resetting is not available. This requirement can trivially be waived for deterministic dynamics, since any combination of observations and actions are …
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The Effects of Altered Partial Pressures of Gas on Cognitive and Neural Function
Oxygen is central to neural function, yet the precise mechanisms and effects by which varying <br/>oxygen levels, whether through Hypoxia, Hyperoxia, or Hyperbaric Oxygen Therapy (HBOT), <br/>shape cognition and brain activity remain incomplete. This thesis adopts a novel, multi-modal …
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Diffusion and Magnetization Transfer Studies of Neural Tissue
… transfer do not offer a unique window to neural function, as had been suggested by some reports in the literature. Rather, our studies taken together with the literature suggest that both these phenomena affect the standard hemodynamics-dependent functional MRI signal. The work presented …
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C. elegans as a Platform for Multimodal Neural Data Integration
… gaps that hinder unified understanding of neural function. This thesis examines the nematode Caenorhabditis elegans as a platform for integrating diverse neural data modalities, offering a pathway to bridge these gaps. The hermaphrodite C. elegans, with its completely mapped connectome, …
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Genome-wide association study of persistent developmental stuttering
… In addition, the pathways in which these genes function to potentially disrupt the fluent production of speech were investigated. Functional significance was found with relevance to three functional categories pertaining to neural development, neural function, and behavior. Many of the genes …
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Technologya nd Protocolsf or Translational Researchin ElectricalS timulation
… (tDCS) have been demonstrated to modulate neural function. Weak constant current is applied via scalp electrodes leading to subthreshold changes in neuron membrane potentials. Neuromodulation of the cortex using direct current (DC) stimulation may be a viable treatment for neurological …
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Precision and reliability of cochlear nerve response in mice lacking functional synaptic ribbons
… 1000 spikes per second. To gain insight into the function of this specialized presynaptic molecular machinery, we characterized the response properties of single auditory nerve (AN) fibers in a mouse with targeted deletion of a presynaptic scaffolding gene, bassoon, in which ribbons are no longer …
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A Neuroethology Approach For Insect Senses And Behavior
Neuroethology is the study of neural basis of natural behavior. I studied learning using sound as a cue in fruit flies and made recordings from the Johnston's organ (JO), I also investigated associative learning in mosquitoes. Finally, I studied Salticid (jumping) spiders to investigate the neural …
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Applications in Neurorobotics
… be a requirement for understanding higher-order neural function. On the other, the cognitive capabilities of humans remain unparalleled by artificial agents. Emulating biology is one strategy for creating more capable artificial intelligence. Despite these strong motivations for creating …
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EGFR signaling regulates synaptic connectivity via Gurken
The synapse is the essential unit of neural function. It is critical to understand how synapses form during development, how they are maintained throughout the life of an organism, and how their structure and function are affected by neural activity. An understanding of these aspects of synapses …
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Toward the Understanding of Brain’s Molecular Language
… has established that proteins are the central functional molecules of the cell, yet translating this knowledge into an understanding of emergent neural phenomena and effective treatments for neurological disorders remains elusive. We argue that this paradox stems from studying proteins in …
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Robust hardware elements for weightless artificial neural networks
… hardware elements for weightless artificial neural systems with a bias towards high integrity avionics applications. The author initially reviews the building blocks of physiological neural systems and then chronologically describes the development of weightless artificial neural systems. …
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Investigating brain-wide neural mechanisms using fMRI and novel tools
Defining the neural mechanisms that coordinate behavior requires characterizing the activity dynamics of diverse brain regions and neural circuit elements. My thesis explores such dynamics to help understand brain-wide processing of rewarding and aversive stimuli relevant to decision making. My …
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Computational Analysis of Functional Imaging in the Primary Auditory Cortex
Functional imaging can reveal detailed organizational structure in cerebral cortical areas, but neuronal response features and local neural interconnectivity can influence the resulting images, possibly limiting the inferences that can be drawn about neural function. Historically, discerning the …
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Childhood Trauma And Emotion Processing Neurocircuitry
… 7-15. In four inter-related studies, we test neural function and functional connectivity of core emotion processing regions, including the amygdala, insula, and pregenual/subgenual anterior cingulate cortex (pgACC/sgACC). To examine the relevance of observed neurological changes, we evaluate …
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Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
Recent advances have defined distinct neural progenitor and early interneuron pools in the developing spinal cord and the molecular events that influence progenitor cell fate. However, these early neurons have not been traced to adult neuron types. The transcription factor Mash1 is transiently …
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