Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Neural connectivity"”.
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Modeling neural connectivity of caenorhabditis elegans
… the use of modeling techniques to estimate the connectivity of a nervous system by analyzing data recorded from its neurons. In this thesis, three main methods were implemented to solve this task: Bayesian inference, artificial neural networks, and ODE reverse engineering. The goal is to apply …
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Inference of functional neural connectivity and convergence acceleration methods
The knowledge of the maps of neuronal interactions is key for system neuroscience, but at the moment we possess relatively little of it . The recent development of experimental methods which allow a simultaneous recording of the spiking activity, but not the intracellular voltage, of thousands of …
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Computational tools for monitoring neural connectivity using calcium imaging
… light-activated manipulation and monitoring of neural activity that offer powerful alternatives to traditional electronic and chemical methods. Along with light-evoked activity, many technical advancements have been made that allow for facilitated optical delivery, activation, and recording of …
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Molecular Mechanisms Regulating Neurite Growth, Innervation and Survival
The establishment of correct neural circuitry in the nervous system requires the interplay, integration, and coordination of a diverse set of cells and signals during development and in the adult. Two important events are the regulated initiation and growth of dendrites that receive and process …
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Sensitive Periods for the Effects of Childhood Maltreatment on Functional Connectivity in Cognitive Control and Risk Processing Systems
… differentially impact longitudinal changes in neural processes of risk-related decision making. Using conditional growth curve modeling, we examined how abuse and neglect across three developmental periods (early childhood, school age, and adolescence) are associated with longitudinal changes …
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EXPERIENCE-DEPENDENT STRUCTURAL PLASTICITY IN A NATURALLY BEHAVING ANIMAL MODEL
… the number or shape of spines which change the neural connectivity in the brain. The regulation of a neuron's structure may lead to changes in future behavior via altered processing of sensory stimuli. The following chapters of this dissertation are aimed at identifying signaling pathways that …
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Mother-newborn EEG connectivity during affectionate touch and impact of hypoxic-ischaemic encephalopathy
… (BAMBY) study to assess mothers’ and babies’ neural responses to affectionate touch in the days after birth. I recruited and studied 37 mother-newborn dyads, recording hyperscanning electroencephalography across social (mother and baby skin-to-skin) and nonsocial (mother and baby separate) …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… life can lead to long-term changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this dissertation used zebrafish as a tool to: i) Establish the developmental window of susceptibility for DomA toxicity, ii) Characterize …
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Elucidating the neural circuitry underlying social spacing in Drosophila melanogaster through the lens of neuroligin 3
… them, and the entire group. To understand the neural basis of complex social behaviour, we can study simpler behaviours that precede and mediate them. Social spacing, the typical distance between individuals in a group, is an easily quantifiable behaviour in Drosophila melanogaster. Here, I …
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Understanding Neural Burst Patterns Through Graph Neural Network Explainability in Simulated Neuronal Networks
Spontaneous bursting activity in neural networks represents a fundamental mode of informationprocessing in the brain, yet the mechanisms triggering these synchronized events remain poorly understood. While graph-based representations of neural networks are established, discovering the specific …
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Connectomics of extrasynaptic signalling: applications to the nervous system of Caenorhabditis elegans
Connectomics – the study of neural connectivity – is primarily concerned with the mapping and characterisation of wired synaptic links; however, it is well established that long-distance chemical signalling via extrasynaptic volume transmission is also critical to brain function. As these …
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Effect of high-beta versus gamma binaural beat exposure on immediate and delayed recall
… frequency band has been linked to alterations in neural connectivity and increased attention during working memory tasks, while stimulation in the Beta frequency band has been associated with increased memory performance. However, there is a lack of direct comparison between the effects of …
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Structural and Functional Properties of Social Brain Networks in Autism and Social Anxiety
… is to precisely characterize the topology of neural connectivity within the DMN in SAD and ASD and neurotypical controls in order to test the following hypotheses through functional and structural connectivity analyses of the DMN. Our analyses demonstrate increased coavtivation of the …
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Dissecting the Genetic Basis of Convergent Complex Traits Based on Molecular Homoplasy
… in mammalian vocal learners, ~25% function in neural connectivity, auditory or speech processing. Remarkably, these include a group of 6 genes from the ROBO1 axon guidance pathway. In birds, I found ROBO1 and its ligand SLIT1 show convergent differential expression in the motor output song …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… life can lead to long-term changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this dissertation used zebrafish as a tool to: i) Establish the developmental window of susceptibility for DomA toxicity, ii) Characterize …
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Scalable Subcellular Resolution Mapping of the Human Brain
… architectures of cells and their system-wide connectivity is essential for interrogating system function and dysfunction. Extensive efforts have been made toward characterizing cells through various omics approaches, and have established invaluable databases yielding new insights. However, we …
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Development of Neuroconnectivity and Inhibitory Control: Relation to Social Cognition in Late Childhood
… dependent on inhibitory control and that the neural foundations of both these skills are measurable in infancy. I tested this model using growth curve and structural equation modeling and show that 10-month, but not 5-month, frontotemporal coherence predicts social cognition in late childhood …
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Development of the multi-scale dynamic modeling techniques for multi-modal brain recordings
… and the behaviors, the investigation of the neural population dynamics is mainly limited by the single-scale analysis. My goal is to develop a multi-scale dynamical model for the collective activity of neuronal populations. First, I introduced a bio-inspired deep learning approach, termed …
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Music Notation-to-Color Synesthesia and Early Stages of Music Education: A Grounded Theory Study
… condition characterized by over-abundant neural connectivity between commonly highly specialized areas of the brain. The developmental form of the condition often results in automatic and consistent cross-sensory associations between perceived stimuli and commonly unrelated brain regions. …
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NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… no study assessed the possible efficacy of neural precursor/stem cell (NPC) transplantation, that has already been proved beneficial and safe for many neurological disorders, such as Parkinson’s disease, spinal cord injury, ischemia and multiple sclerosis. Mechanisms of action of NPCs can …
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