Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Neural Tube Defects"”.
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Genetic factors in human neural tube defects.
Contains fulltext : 145592.pdf (Publisher’s version ) (Open Access)
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Folic Acid Intake, Maternal Obesity and Neural Tube Defects
… is a risk factor of delivery of an infant with neural tube defect (NTD) and to study relationships between folic acid intake during the periconceptional period and the risk of NTD in overweight and non-overweight women.</p> <p>"Methods:" We used data from a state-wide case-control study …
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Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
… a possible mechanism for teratogen-induced birth defects. Neural tube defects (NTDs) are the second most common fetal malformations. Non-specific stimulation of maternal immune system prevents birth defects. This study investigated the role of dysregulated apoptosis in formation of NTDs from two …
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Neural tube defects in rodents caused by a tap water contaminant
… 2006, the Hrubec group suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. Unintentional exposure to a teratogenic agent in tap water was identified as the cause. We aimed to identify the contaminant, but first we demonstrated that the NTDs were pathological …
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The prevalence of neural tube defects and the outcome of myelomeningocele in Cape Town
… study was designed to document the prevalence of neural tube defects in Cape Town and to determine the outcome of children born with a myelomeningocele and operated on within the Neurosurgical service of the University of Cape Town. The aim of the prevalence study was to document the frequency of …
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Iron and its Relationship to Neural Tube Defects among Offspring of Texas Border County Women
Neural tube defects (NTDs) are major malformations of the developing central nervous system. The most common types are anencephaly and spina bifida. In 1992, a small case-control study in Cameron County, TX by the Texas Department of Health found hematocrit values among women giving birth to babies …
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Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review
Introduction: Neural tube defects (NTDs) are an important global health concern with high morbidity and mortality. Enhancing access to healthcare for children born with NTDs is crucial for improving health systems and service delivery. Methods: We conducted a systematic review to assess the global …
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Assessment of neural tube deffects in two Northern Namibia hospitals: Incidence, seasonal variation, risk factors and prevention strategies for folate sensitive defects
Neural tube defects (NTDs) represent severe congenital abnormalities of the nervous system and are among significant abnormalities associated with a high mortality and morbidity rates. Studies reported that the incidence of NTDs varies worldwide, with the highest found in low-income countries. Most …
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Antiretroviral Regimen and Pregnancy Outcomes of Women Living with HIV in a US Cohort
… identified in this cohort, none of which were neural tube defects. There was no perinatal transmission of HIV to any of the infants. This small cohort of women provides high-quality data regarding the safety and efficacy of INSTI use in resource-rich settings.
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Characterization of NHLRC2 gene-edited mice: a model for bovine developmental duplications
… is a congenital abnormality where duplication of neural crest derived tissues occurs during embryonic development. A common phenotypic presentation of the condition includes calves born with polymelia most frequently involving duplication of the front limbs that protrude from the neck or shoulder …
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
The neural tube, the precursor to the vertebrate central nervous system, forms through the process of neurulation. During neurulation, a flat neural plate folds and the lateral edges bind to form a closed tube. Failure of neurulation results in neural tube defects (NTD). In humans, NTD causes …
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Direct detection of homocysteine and syntheses of lanthanide complexes as biosensors
… implicated in a number of other diseases such as neural tube defects, pregnancy complications, and renal failures. The monitoring of Hcy levels in plasma is of current concern. To date, the biochemical mechanism by which Hcy is involved in disease states is unclear. Herein, we describe highly …
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CRISPR/CAS9 mediated gene editing for the improvement of beef and dairy cattle
… this mutation are affected with a broad range of neural tube defects and commonly exhibit polymelia, which is the presence of additional limbs. The mutation has been identified as a single-nucleotide polymorphism resulting in a valine to alanine substitution in a highly conserved protein-coding …
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Economic evaluation of antenatal screening for Down Syndrome and serious congenital heart defects in Norway
… with the detection of foetal anomalies or defects, such as Down syndrome, congenital heart defects or neural tube defects. The detection can in some cases lead to the pregnancy being terminated, whilst in other cases it may prepare the parents for a life with a child who may requiremore …
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Immunoteratological Studies of Diabetic Embryopathy Using Gene Expression Analysis
… of pregnant women with type I diabetes. Immune defects in the pathogenesis of diabetic embryopathy have been suggested. We hypothesized that activated immune system can counteract diabetic effect and result in prevention of diabetic embryopathy. Diabetes was induced in pregnant ICR mice by …
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The role of folic acid supplementation on exencephaly induced by maternal exposure to sodium valproate in the TO mouse
… period prevents a substantial proportion of neural tube defects (NTD). The mechanism of preventive effect of FA is not known. In addition to genetic factors, dose, timing and duration of supplementation during pregnancy may be important in protecting the embryos against occurrence of NTD …
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Nutrient intakes, compliance with recommendations and key sources in women of child-bearing age (18-50y) in Ireland
… a folic acid supplement to reduce the risk of neural tube defects (NTDs) in an occurring pregnancy. Objectives: The overall aim of this thesis was to estimate the nutrient intakes among WCBA in Ireland. The first aim was to estimate the mean daily intake of energy, macronutrients, dietary fibre …