Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Neural Tube"”.
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Genetic factors in human neural tube defects.
Contains fulltext : 145592.pdf (Publisher’s version ) (Open Access)
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Folic Acid Intake, Maternal Obesity and Neural Tube Defects
… is a risk factor of delivery of an infant with neural tube defect (NTD) and to study relationships between folic acid intake during the periconceptional period and the risk of NTD in overweight and non-overweight women.</p> <p>"Methods:" We used data from a state-wide case-control study …
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Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
… mechanism for teratogen-induced birth defects. Neural tube defects (NTDs) are the second most common fetal malformations. Non-specific stimulation of maternal immune system prevents birth defects. This study investigated the role of dysregulated apoptosis in formation of NTDs from two …
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TWIST1: a subtle modulator of neural differentiation and neural tube formation
… epiblast precursor cells through Neurulation. Neural induction can be studied in its main aspects in vitro. However, the process is poorly understood, especially in regard to when and how a cell becomes specified, and then committed, to be a neural cell. It is, on the other hand, well …
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Neural tube defects in rodents caused by a tap water contaminant
… 2006, the Hrubec group suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. Unintentional exposure to a teratogenic agent in tap water was identified as the cause. We aimed to identify the contaminant, but first we demonstrated that the NTDs were pathological …
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The role of actomyosin contractility in zebrafish neural tube formation through hollowing.
The neural tube is an epithelial tube that forms the embryonic brain and spinal cord through the process of neurulation. In amniotes, it forms in two different ways: in the anterior region, primary neurulation occurs through the folding of an already polarised epithelial sheet; and posteriorly, …
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The prevalence of neural tube defects and the outcome of myelomeningocele in Cape Town
… study was designed to document the prevalence of neural tube defects in Cape Town and to determine the outcome of children born with a myelomeningocele and operated on within the Neurosurgical service of the University of Cape Town. The aim of the prevalence study was to document the frequency of …
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Iron and its Relationship to Neural Tube Defects among Offspring of Texas Border County Women
Neural tube defects (NTDs) are major malformations of the developing central nervous system. The most common types are anencephaly and spina bifida. In 1992, a small case-control study in Cameron County, TX by the Texas Department of Health found hematocrit values among women giving birth to babies …
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Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review
Introduction: Neural tube defects (NTDs) are an important global health concern with high morbidity and mortality. Enhancing access to healthcare for children born with NTDs is crucial for improving health systems and service delivery. Methods: We conducted a systematic review to assess the global …
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Cell mechanics-based modelling and in toto imaging describe a new mode of lumen formation in chicken neural tube
Lumen formation creates epithelial tubes and vesicles that underlie the morphology and function of many major organs, such as ear, brain, and lung. The specific morphogenetic pathways taken may vary between organs and species, but the resultant single lumen remains constant. In chick neurulation, …
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
The neural tube, the precursor to the vertebrate central nervous system, forms through the process of neurulation. During neurulation, a flat neural plate folds and the lateral edges bind to form a closed tube. Failure of neurulation results in neural tube defects (NTD). In humans, NTD causes …
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The Role of Pax3 in Neuronal Differentiation of the Ophthalmic (OpV) Trigeminal Placode and Neural Tube during Chicken Embryonic Development
… it is not clear whether this reduction is due to neural crest or placode cells. We have used electroporation in the chick model system to block or ectopically express Pax3 at key times in opV placode development. Using several markers of placode cell differentiation, we have determined the …
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Characterization of an Enhancer Upstream of Msx3 and its Role in Development of the Neural Tube of Embryonic and Larval Zebrafish
… from an epithelial sheet of cells called the neural plate that subsequently folds to become a rod of cells called the neural tube. Several signaling pathways act on the neural progenitors of the neural tube to give rise to the diverse set of neurons and glia that will make up the spinal cord …
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Assessment of neural tube deffects in two Northern Namibia hospitals: Incidence, seasonal variation, risk factors and prevention strategies for folate sensitive defects
Neural tube defects (NTDs) represent severe congenital abnormalities of the nervous system and are among significant abnormalities associated with a high mortality and morbidity rates. Studies reported that the incidence of NTDs varies worldwide, with the highest found in low-income countries. Most …
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Effects of Homocysteine on Cardiac Neural Crest Cell Formation
… of congenital detects, many of which resemble neural crest (NC) cell ablation. However, the etiological mechanism is not known. The purpose of this study was to determine if Hcys altered the number and/or the proliferation of NC cells or their progenitors /?? Uw. Hcys was experimentally …
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Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
… required for cell fate specification. During neural development, complex interactions of diverse transcription activators and repressors regulate lineage specific programs. The multitudes of neuronal subtypes generated during development is dependent on spatio-temporally controlled expression …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
Neural tube is a structure within the developing vertebrate embryo that gives rise to the central nervous system consisting of the brain and the spinal cord. Within the neural tube, there are pools of specific neural progenitors that give rise to specialised types of neurons. Those progenitors are …
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Characterization of Dishevelled Associated Activator of Morphogenesis 2 (Daam2) in Wnt Signaling During Early Embryonic Development
… defect disorders including the most common human neural tube closure defect: spina bifida. Modulation of the actin cytoskeleton via the non-canonical Wnt signaling pathway mediate cell polarity and cell migration that are required for proper vertebrate gastrulation and subsequent neurulation. …
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A multi-dimensional microfluidic platform recapitulating chemotactic and morphogenic chemical gradients
… based patterning of the vertebrate ventral neural tube. Using the presumptive enhancer for the p3 progenitor domain gene Nkx2.2, our findings indicate that such an enhancer would both negatively and positively regulate Nkx2.2 expression in response to Wnt signaling. However we found that the …
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