Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Neural Stem Cells (NSCs)"”.
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Neural stem cell differentiation in collagen scaffolds for retinal tissue engineering
Rat neural stem cells (NSCs) were cultured in monolayer or in porous collagen scaffolds and exposed to neurogenic or non-neurogenic medium to determine the effects on neural differentiation and neurite growth. Nestin, [beta]III-tubulin, and GFAP expression were determined using immunofluorescent …
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Primitive Neural Stem Cells in the Mouse Brain
Neural stem cells (NSCs) reside in the tissue lining the lateral ventricles of the adult mouse brain. At the top of the hierarchy are primitive (p)NSCs that arise in advance of definitive (d)NSCs embryonically. After the discovery that pNSCs persist in the adult mouse brain, I sought out to …
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DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM
The neuronal differentiation of neural stem cells (NSCs) has received much attention due to its potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to …
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Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
Neural stem cells (NSCs) participate in a delicate balance between maintaining cellular identity through self-renewal and differentiating into myriad neural cell types. Understanding exactly how epigenetic mechanisms regulate this balance and the subsequent differentiation process in adult …
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Impact on Endogenous Neural Stem Cells and Neurogenesis by Drugs of Abuse: From Fetal Neurodevelopment to the Adult Brain
Neural stem cells (NSCs) are a subpopulation of cells, found within the fetal and adult brain, that are integral to brain development, maintenance, and repair. Neurogenesis is the process through which NSCs proliferate and differentiate to create new neural cells within the central nervous system. …
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The Tumor-Suppressive Properties of Neural Stem Cells
… (GBM) is an aggressive central nervous system malignancy that commonly causes immune suppression in patients to avoid immune recognition and clearance. This complicates treatment options and limits the effectiveness of immunotherapy strategies. Interestingly, GBM formation can stimulate …
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Potential Rest Targets In Neural Stem Cells and Glioblastoma-Derived Stem Cells
… are caused by self-renewing glioblastoma-derived stem cells (GSCs). At the current time, the mechanisms that regulate self-renewal and other oncogenic properties of GSCs remain unknown. Recently, we found transcriptional repressor REST maintains self-renewal in neural stem cells (NSCs) and in …
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Evaluating the Effect of Chronic Alcohol, Cocaine, and Co-Administration on Endogenous Adult Neural Stem Cell Survival, Differentiation, and Proliferation
… brain damage incurred by chronic drug abuse. Neural stem cells (NSCs) are a promising target to stimulate brain recovery, yet little is known about the effect of long term co-abuse of alcohol and cocaine on this cell population. Additionally, sex differences in NSC behavior following chronic …
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Understanding the roles for CELF2 in post-transcriptional regulation for the fate of neural stem cells.
… development of the mammalian brain is built by neural stem cells (NSCs) which differentiate into neurons, glial cells and will self-renew to grow the NSC population. The balancing of self-renewal and differentiation is precisely orchestrated as the brain develops. The fate of NSCs are achieved …
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A novel function of tissue inhibitor of metalloproteinase-1 as a chemoattract molecule for neural stem cells
Recently neural stem cells (NSCs) were reported to migrate to damaged brain area, such as brain tumor or ischemic region. So, we hypothesized that human glioma or ischemic tissues secreted chomoattract molecules that induce NSC migration toward that area. In present study, we reported one candidate …
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Uncovering the Importance of Cell Morphology, Genetic Regulation, and Neuronal Signalling in Quiescent Neural Stem Cells
Neural stem cells (NSCs) are essential for their ability to produce new neurons during neurogenesis. These cells undergo quiescence, the state when quiescent cells are metabolically active but do not produce new neurons. Understanding and manipulating this critical state is essential due to …
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Understanding the role of dMob4 in postembryonic Neural Stem Cell mitotic reactivation
Brain homeostasis supports cognition and neural plasticity, the brains’ ability to adapt to its environment throughout life. These processes rely on replenishment from stem cells in the brain, termed Neural Stem Cells (NSCs). In the adult brain, most NSCs exist in a quiescent state and must …
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The Role of p66Shc in Stem Cells: Signalling, Identity and Apoptosis
… apoptosis, the physiological roles of p66Shc in stem cells remain poorly defined. This thesis examines the role of p66Shc in signalling, apoptosis, and extracellular matrix (ECM)-dependent behaviour in embryonic stem cells (ESCs) and neural stem cells (NSCs). In ESCs, deletion of p66Shc enhanced …
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Chemical Genetic Interrogation of Neural Stem Cells: Phenotype and Function of Neurotransmitter Pathways in Normal and Brain Tumor Initiating Neural Precursor Cells
… identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain brings promise for the treatment of neurological diseases and has yielded new insight into brain cancer. The complete repertoire of signaling pathways that governs these cells however remains largely …
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Systemic and local signalling regulating neural stem cell proliferation
Neural stem cells (NSCs) in the brain can be reactivated to exit quiescence and generate new cells in response to injury or disease. Determining the specific signals involved in NSC reactivation is essential to understanding neural regeneration. Investigating NSCs in *Drosophila melanogaster* …
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Multiphysics-based Fluidic Manipulation of Particles: An Experimental and Numerical Study
… manipulation of various bioparticles, such as cells, enables their use as the building blocks to construct complex bioscaffold for tissue engineering, which has the potential to transform the basic research in biology/biomedicine as well as the clinical treatment of some intractable diseases. …
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Dissecting the function of MYEF2 in neural stem cells and glioblastoma
… of approximately ~15 months after diagnosis. GBM stem cells (GSCs) underpin GBM’s aggressiveness, resistance to radiation and chemotherapy, and disease recurrence. Glioblastoma stem cells (GSCs) are capable of tumour formation upon orthotopic transplantation into immunocompromised mice and share …
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Modulation of RNA Cytosine-5 Methylation by Neuronal Activity and Methyl-donor Folate
… methylation (5-mrC) modification in adult mouse neural stem cells (NSCs). Compared to the control, NSCs cultured in folate deficiency or supplementation condition have shown no changes in mRNA expression, but significant changes in mRNA translation efficiency. RNA bisulfite sequencing of both …
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Neural Stem Cells - interaction with the brain and prospects for cell replacement therapy for Stroke
… as well as astrocytes and oligodendrocytes. Neural stem cells (NSCs) could potentially be used to develop novel therapies to restore loss of function after stroke. We generated a NSC line derived as monolayer cultures from the human fetal striatum, termed NS, and described the in vitro and in …
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
The discovery of adult neural stem cells (NSCs) has revealed the potential of endogenous neurogenesis as a therapeutic mechanism for brain repair. Among the neurogenic niches of the adult brain, the subventricular zone (SVZ) responds to cortical injury by generating neuroblasts that attempt to …
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