Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"Neural Stem Cells"”.
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Neural Stem Cells in Brain Tumor Development
… mouse models indicated a central role for neural stem cells and stem cell-like cancer cells in malignant astrocytoma formation. Using stereotactic viral cre-mediated approach, we demonstrate that targeting of tumor suppressor inactivating mutations in the subventricular zone (SVZ) where …
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Transdifferentiation of fibroblasts to neural stem cells
… indistinguishable from an embryonic stem (ES) cell. However, it is still unclear if transcription factors can completely convert the nucleus of a differentiated cell into that of a distantly related somatic cell type with complete transcriptional and epigenetic reprogramming …
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Primitive Neural Stem Cells in the Mouse Brain
Neural stem cells (NSCs) reside in the tissue lining the lateral ventricles of the adult mouse brain. At the top of the hierarchy are primitive (p)NSCs that arise in advance of definitive (d)NSCs embryonically. After the discovery that pNSCs persist in the adult mouse brain, I sought out to …
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The Tumor-Suppressive Properties of Neural Stem Cells
… (GBM) is an aggressive central nervous system malignancy that commonly causes immune suppression in patients to avoid immune recognition and clearance. This complicates treatment options and limits the effectiveness of immunotherapy strategies. Interestingly, GBM formation can stimulate …
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Monoallelic Gene Expression In Human Neural Stem Cells
… widespread autosomal RME in human lymphoblastoid cells (Gimelbrant et al. 2007) and mouse neural stem cells (Wang et al.2010; Li et al. 2012). However, the extent to which RME occurs in human neural tissue is unknown. Using a genome-wide analysis of allele-specific expression in human neural stem …
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Adult Neural Stem Cells and Their Perivascular Niche
Stem cells reside in specialized niches that support their selfrenewal and differentiation. A balance between intrinsic and extrinsic signals mediates stem cell quiescence, activation and proliferation. In the mammalian subventricular zone (SVZ), the stem cells are a subset of GFAP+ astrocytes. A …
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Glioma produced periostin attracts human neural stem cells
"Stem cells from various lineages have been well known for their migration tendency toward glioma and become attractive vehicles to deliver therapeutic genes to brain tumors. However, which factors and mechanisms in these processes are not yet known. In the present study, I aimed at identifying the …
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Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts
… Stroke leads to loss of neurons and also other cells in the brain due to lack of blood supply. Currently no therapies are available to treat stroke-related disability. It has been shown that stroke leads to increased neurogenesis, birth of new neurons, within the brain. This increased …
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Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells
… this thesis is on DAGL driven eCB signaling in neural stem cells (NSC). A role of the eCB system has previously been established in migration, proliferation, and neurogenesis. Here we investigated DAGLα and eCB signaling in the context of differentiation. <br/>The Cor-1 cells were adapted as a …
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Characteristic analysis of mobility inducers for neural stem cells
Recently neural stem cells (NSCs) were reported to migrate to damaged brain areas, such as brain tumors or ischemic regions. Systemic strategy can be effective to cancer therapeutic effect through cell-based gene therapy. From our previous studies, we identified chemoattractant molecules-1(CM-1) …
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Characterization of Neural Stem Cells Using the Nestin Enhancer
… filament, is known as a specific marker for neural stem cells and regulated by the enhancer located on the second intron of the gene. The second intron is highly conserved among species and crucial for the nestin expression in central nerve system (CNS) progenitor cells. The transgenic mice …
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Neural Stem Cells as a Model to Study Huntington’s Disease
… affects the cytoskeletal structures using neural stem cells Q7 (wild type) and Q140 (mHtt) and differentiated neurons as a model for studying HD. In addition we looked at the interference of mHtt protein with RRAS, the downstream signaling components of Plexin/Semaphorin pathway of the …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… due to infiltrating behavior of these glioma cells. Here, author investigated the possibility of treatment for the malignant gliomas with neural stem cell (HB1.F3) transduced with suicidal gene using the tropism of stem cells. MATERIALS AND METHODS: E.coli cytosine deaminase(CD) of suicide …
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Investigating novel direct Notch targets in Drosophila neural stem cells
… cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development. Notch signalling has a simple transduction pathway. Upon Notch ligand binding to the receptor, the Notch intracellular domain (NICD) is released into the nucleus. The …
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Expansion of neural stem cells as a treatment for ischemic stroke
… der Zellzyklusregulatoren Cdk4/Ccnd1 (4D) in neuralen Stammzellen (NSZ) der SGZ oder SVZ ihre G1 Phase verkürzt und dadurch zu einer erhöhten Proliferationsrate führt. Dies hatte eine höhere Anzahl an neugeborenen Neuronen zur Folge, welche die Performance von Mäusen in Hippocampus-abhängigen …
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Dissecting the function of MYEF2 in neural stem cells and glioblastoma
… of approximately ~15 months after diagnosis. GBM stem cells (GSCs) underpin GBM’s aggressiveness, resistance to radiation and chemotherapy, and disease recurrence. Glioblastoma stem cells (GSCs) are capable of tumour formation upon orthotopic transplantation into immunocompromised mice and share …
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Mechanisms of Asymmetric Protein Localization in Drosophila Embryonic Neural Stem Cells
By screening a collection of deficiency lines and testing candidate gene involved in cell polarity, we identified lethal giant larvae (lgl) and discs large (dlg) to play key roles in the basal targeting of Prospero and Miranda. In embryonic and larval neuroblasts of lgl and dlg mutants, all basal …
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
One main goal of stem cell biologists is to efficiently direct stem cells into particular cell fates useful for the treatment or study of neurological disease. Towards that goal, our laboratory has previously developed an in vitro procedure consisting of basic fibroblast growth factor (bFGF), …
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Potential Rest Targets In Neural Stem Cells and Glioblastoma-Derived Stem Cells
… are caused by self-renewing glioblastoma-derived stem cells (GSCs). At the current time, the mechanisms that regulate self-renewal and other oncogenic properties of GSCs remain unknown. Recently, we found transcriptional repressor REST maintains self-renewal in neural stem cells (NSCs) and in …
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Human neural stem cells: region-specific properties and prospects for cell therapy
Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural …
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