Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Neural Progenitors"”.
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Characterisation of neural progenitors from the adult retina and ciliary epithelium
The mammalian central neural retina (CNR) lacks the capability to regenerate, a phenomenon retained by lower vertebrates. However, retinal stem cells have been isolated from the ciliary epithelium of the mammalian retina. Chx10 is a paired-like homeobox transcription factor gene expressed in the …
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Activation of Early Neural Progenitors Is Required for Traumatic Brain Injury-Induced Hippocampal Neurogenesis
… control of a nestin promoter and also contains a neural progenitor-specific regulatory element. By using this line, I have demonstrated that eGFP-expressing cells represent early neural progenitors in the adult dentate gyrus. Performing unilateral controlled cortical injury (CCI) demonstrates that …
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Characterization of an Enhancer Upstream of Msx3 and its Role in Development of the Neural Tube of Embryonic and Larval Zebrafish
… from an epithelial sheet of cells called the neural plate that subsequently folds to become a rod of cells called the neural tube. Several signaling pathways act on the neural progenitors of the neural tube to give rise to the diverse set of neurons and glia that will make up the spinal cord …
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Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
Neural stem cells (NSCs) participate in a delicate balance between maintaining cellular identity through self-renewal and differentiating into myriad neural cell types. Understanding exactly how epigenetic mechanisms regulate this balance and the subsequent differentiation process in adult …
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A Reductionist Approach to Modeling Human Corticogenesis
… process that involves three major milestones: 1) neural induction and folding of the neuroepithelium, 2) areal patterning and generation of various progenitor types, and 3) corticogenesis. Our current understanding of the molecular and cellular basis of cortical development comes largely from …
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Transcriptional and Post-Translational Mechanisms Contribute to Maintenance of Rest In Neural Tumors
… regulates neuronal lineage specification in neural progenitors by binding to its consensus <em>RE-1</em> element(s) located in the regulatory region of its target neuronal differentiation genes. The developmentally coordinated down-regulation of REST mRNA and protein in neural progenitors …
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Notch signalling in spinal cord patterning: Crosstalk and fate decisions
… During development, initially equivalent neural progenitors divide and give rise to a specific pattern of differentiated neurons. Understanding how this pattern arises would have far reaching impact, not just in developmental biology but also in the understanding of developmental …
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The design and assembly of neural circuits for vocal communication in songbirds
… emphasis on the High Vocal Center. Neuronal progenitors in the juvenile zebra finch brain were identified by fate mapping using engineered retroviruses. Multiple populations of neural progenitors appear to exist in the juvenile zebra finch brain, and each produces different types of neurons. …
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The Role of Adult Neurogenesis in Cocaine Addiction
… learning and memory. Proliferation of SGZ neural progenitors is decreased by drugs of abuse, yet it is not clear how the type and amount of drug as well as the pattern of administration changes long-term effects on neurogenesis. In addition, it is unclear what role if any SGZ neurogenesis …
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Effects of prolonged mitosis on neural stem cells in vivo during development
… strongly tied to disrupted mitotic processes in neural stem cells during cortical development. Yet, how perturbed neural stem cell mitosis kinetics affects cell fate following neural stem cell division is not well understood. Our lab recently discovered prolonging mitosis of mouse neural …
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ANALYZING THE FUNCTIONS OF PREFOLDIN COMPLEX IN NEUROBLAST HOMEOSTASIS OF DROSOPHILA MELANOGASTER
… defects of both neuroblasts and Intermediate Neural Progenitors (INPs). Co-depletion of Prefoldin and Pins also induces dedifferentiation of INPs back into neuroblasts, while depletion either Prefoldin or Pins alone is insufficient to do so. Furthermore, knocking down either α- or β-tubulin in …
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The OP27 cell line as a model system to study the effects of FGF-2 in olfactory neuronal development
… role in regulating the proliferation of neural progenitors, the main focus in this study was its effect on neuronal differentiation.
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Study of Rest As A Negative Regulator of P16Ink4A
… in early embryos, but downregulated in neural progenitors concomitant with onset of neuronal differentiation in these cells. REST has been widely studied as a negative regulator of neuronal differentiation genes. Our recent work identified a novel role for REST in control of cell …
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The evolution of neuronal progenitor cell division in mammals: The role of the abnormal spindle-like microcephaly associated (Aspm) protein and epithelial cell polarity
… cell division (ultimately generating more progenitors), the constraints on progenitor proliferation, and how neural progenitors have overcome these constraints in the process of primate encephalization are the primary questions of interest. Both functionally analyses in the mouse model …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
Neural stem cells produce all the cells of the nervous system and regulation of proliferative behaviour is crucial for proper brain development. Over-proliferation of NSCs can also lead to disease, resulting in the formation of tumours. There is a delicate balance between NSC proliferation, …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… was also used to investigate the delivery of neural progenitor cells one week after injury. After four weeks, viable implanted cells were found to have differentiated into astrocytes, oligodendrocytes, endothelial cells, neurons, and possibly macrophages/microglia. These results demonstrate …
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Novel mechanism in astrocyte gene regulation and function
… upregulated during the differentiation of neural progenitors to astrocytes and precedes the expression of astrocyte markers such as GFAP and SPARCL1. Overexpression of NFI-X3 dramatically upregulates GFAP and SPARCL1 expression in glioma cells, while the knockdown of NFI-X3 diminishes the …
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Novel Regulation of the Cell Cycle During Cell Fate Decisions in the Central Nervous System
… of stem-like tumor initiating cells (TICs) in neural cancers like glioma and neuroblastoma. Understanding how normal neural stem and progenitor cells regulate their growth and differentiation decisions throughout life is of high priority. Spy1 (Speedy, Spdya, RINGO) is a unique cyclin-like …
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Roles of Neurogenin and Geminin in Vertebrate Neurogensis
… and geminin in vertebrate neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target genes. Here, …
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Determinants of cns adult neurogenesis are sex, hormones, mouse strain, age, and brain region
… cells is poorly studied. Here, we analyze SD of neural progenitors in 6-8wk and 6-8mo normal C57BL/6, SJL/J and BALB/c mice in the subventricular zone (SVZ), dorsolateral horn (DLC), corpus callosum (CC), and parenchyma. With a short 2 h BrdU pulse, no gender and strain differences are present at …
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