Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"Neural Progenitor Cells"”.
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Transposable Elements in Neural Progenitor Cells
… element called Line-1 was found to be active in neural progenitor cells and in the brain. Several studies report Line-1 transcription and frequent retrotransposition during normal brain development, with further evidence that Line-1 induced retrotransposition can influence neuronal gene …
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Intracellular signaling cascades in the dopaminergic specification of fetal mesencephalic neural progenitor cells.
Neural stem (progenitor) cells (NPCs) from fetal tissue are an ideal transplantable cell source. They divide rapidly, are able to generate cells of all three neural lineages and do not divide uncontrolled once transplanted into a host organism. To obtain large quantities of cells for …
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Characterization of neural progenitor cells of the embryonic and adult dorsal root ganglia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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An injectable, biomaterial-based therapy to promote endogenous neural progenitor cells in a hemorrhagic stroke lesion
… therapy into the stroke lesion to restore neural elements for improved function. The principal objective of this thesis was to evaluate the ability of an injectable, gelatin-based biomaterial (gelatin-hydroxyphenylpropionic acid, Gtn-HPA) incorporating epidermal growth factor (EGF) to …
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Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… (ELAC) promote proliferation process in adult neural progenitor cell (NPC) via PKC-activating, thus improving the brain's endogenous neurogenic response to traumatic injury. Occurrence of these compounds on minute amounts on the known sources is a major obstacle to consider them adequate as …
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Analysis and functional characterization in embryonic mouse neocortex of a set of human-specific genes expressed in neural progenitor cells of fetal human neocortex
Einführung: Eine entscheidende Ursache für das Aufkommen der den modernen Menschen charakterisierenden kognitiven Funktionen ist in der beachtlichen Vergrößerung des menschlichen Neocortex innerhalb der letzten 5-7 Millionen Jahre zu finden. Die Identifizierung der dieser Entwicklung zu Grunde …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… integrated neurons are generated from progenitor cells. In the adult mammalian brain two sites of high density cell division have been identified that contain neural progenitor cells retaining the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the …
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Investigation of miRNAs Expression in a Citron-Kinase Mutant Model of Microcephaly
… the requirement of miRNAs for differentiation of neural progenitor cells starting at embryonic day 12.5 (3). Together, this evidence links the role of miRNAs to neurogenesis and thus this relationship warrants further investigation. Here miRNA expression has been characterized between the wild …
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Role of Tyrosine Receptor Kinase B in the Development and Function of the Central Nervous System
… of new neurons. Mice lacking TrkB in hippocampal neural progenitor cells had impaired proliferation and neurogenesis, and are behaviorally insensitive to antidepressive treatments. Specific deletion of NF1, an antagonist of Ras, in adult neural progenitor cells enabled rapid proliferative and …
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Sox2 co-occupies distal enhancer elements with cell-type-specific POU factors to specify cell identity in embryonic stem cells and neural precursor cells
… states, that of pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs), but what common or distinct roles Sox2 may play in these cell types not fully understood. Further, the molecular mechanisms by which Sox2 can specify two distinct cell identities are as of …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
… starts during embryogenesis with the main neural progenitor cells, classified as apical (APs) and basal progenitors (BPs). BPs are significantly enriched and highly proliferating in gyrencephalic species compared to lissencephalic, leading to an increased neuronal outcome and to cortical …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… hypoxia, or vascularisation. Growing cells outside the primary tumour as primary cell lines and then implanting them orthotopically into rodent brains did not change their metabolic phenotype. In addition, modulation of the microenvironment *in vitro* (including hypoxia, growth factors …
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The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development of Cerebellum and Neocortex
… proteins in the generation and organization of neural tissues. Here we report a focal distribution of Pals1, a central component of the apical complex, in progenitors. Our genetic analyses revealed that Pals1 deletion in the brain developed a remarkably undersized and disrupted layer structure …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… of macrophages, astrocytes, and endothelial cells. The scaffold was able to fill the cavity and provide a substrate for cellular migration into the defect. Incorporation of a Nogo receptor molecule aimed at binding inhibitory myelin proteins did not appear to promote axonal regeneration, but …
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The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain
… affecting the numbers of neurones or total cells. GDF-5 was found to increase the proportion of neurons that were dopaminergic. The numbers of Nurr1-positive cells were not affected by GDF-5 treatment, but GDF-5 did increase the numbers of Nurr1- positive cells that expressed tyrosine …
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Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
… I performed ChIP-seq and RNA-seq in human neural progenitor cells and found evidence that FOXP2 may actively modify the chromatin landscape. This lead me to hypothesize that by modifying the chromatin landscape of neural progenitors FOXP2 turns off cellular programs that maintain an …
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Cerebral Organoids as 3-Dimensional Grafts in Traumatic Brain Injury
… these tissues using several approaches, such as neural progenitor cells, mesenchymal stem cells, and direct astrocyte-to-neuron conversion. Each of these approaches has shown promise; however, each has limitations to regenerative potential. The recent emergence has led researchers to examine …
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CONSEQUENCES OF CHROMATIN MOSAICISM AND PERSISTENCE IN NEURONAL PLASTICITY AND DISEASE
… genome-wide H3K9me3 profiling in patient-derived neural progenitor cells, I find that the mutation-length CGG expansion on the X chromosome drives inter-chromosomal clustering of heterochromatin domains at Megabase-scale H3K9me3 domains, termed BREACHes. BREACHes form on the X chromosome and …
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Two Sides of The Same Coin in The Levodopa Treatment of Parkinson's Disease
… present study investigated the effects of Hcy on neural progenitor cells (NPCs) both in vitro and in vivo. I found that Hcy export from astrocytes was induced by the COMT substrates L-dopa. So, I have examined the role of NMDA receptor-mediated activation of the extracellular signal-regulated …
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Immunotherapy for Alzheimer’s Disease: IVIg Delivery to the Hippocampus in a Mouse Model of Amyloidosis
… both the proliferation and survival of neural progenitor cells in the dentate gyrus. Compared to IVIg-alone, IVIg-FUS also increased pro-neurogenic cytokine interleukin-2 in the serum and decreased pro-inflammatory cytokine tumor necrosis factor alpha in the hippocampus. Aβ pathology was …
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