Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"Neural Progenitor"”.
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Transposable Elements in Neural Progenitor Cells
… element called Line-1 was found to be active in neural progenitor cells and in the brain. Several studies report Line-1 transcription and frequent retrotransposition during normal brain development, with further evidence that Line-1 induced retrotransposition can influence neuronal gene …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
Neural progenitor cell transplantation has been widely explored in traumatic spinal cord injury (SCI) but has yet to be evaluated as a treatment for degenerative cervical myelopathy (DCM), a non-traumatic form of spinal cord injury. Importantly, the extent of astrogliosis and extracellular matrix …
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Intracellular signaling cascades in the dopaminergic specification of fetal mesencephalic neural progenitor cells.
Neural stem (progenitor) cells (NPCs) from fetal tissue are an ideal transplantable cell source. They divide rapidly, are able to generate cells of all three neural lineages and do not divide uncontrolled once transplanted into a host organism. To obtain large quantities of cells for …
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Characterization of neural progenitor cells of the embryonic and adult dorsal root ganglia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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From mice to men - astrocytes and neural progenitor cells in neural plasticity and regeneration
… become maladaptive and lead to the inhibition of neural plasticity and other regenerative responses. Animal studies suggested that some reactive astrocytes can act as neural stem cells after injury. We hypothesized that some reactive astrocytes within the epileptic foci of patients with epilepsy …
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In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
… trauma occurs. The discovery of neurogenesis and neural stem cells in the adult brain has opened up new avenues for treatment of the injured brain. In the adult brain, neural stem cells are present in two distinct neurogenic areas, the subventricular zone and the hippocampus. These neural stem …
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Collective Behavior of Drosophila Melanogaster Neural Progenitor and Imaginal Disc Cells within Controlled Microenvironments
… the Optic Stalk (OS). Collective migration of neural and retinal progenitor cells (RPCs) from the developing brain lobes (DBL) to the Imaginal Disc (ID), through the OS, is a fundamental part of regenerative strategies in retina. Developmental signals governing retinal cell fate and migration …
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
Apoptosis is evolutionally conserved, and plays central roles during normal development of the nervous system. The number of embryonic neuroepithelial cells (NECs) is regulated by programmed cell death when NECs are substantially proliferated by growth factors(GFs). The extrinsic factors such as …
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An injectable, biomaterial-based therapy to promote endogenous neural progenitor cells in a hemorrhagic stroke lesion
… therapy into the stroke lesion to restore neural elements for improved function. The principal objective of this thesis was to evaluate the ability of an injectable, gelatin-based biomaterial (gelatin-hydroxyphenylpropionic acid, Gtn-HPA) incorporating epidermal growth factor (EGF) to …
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Bioengineering Microporous Annealed Particle Scaffolds to Recruit Neural Progenitor Stem Cells and Promote Angiogenesis in the Stroke Core
… highly attractive. However, this process of neural regeneration is complex and requires a series of controlled biological events, such as recruitment and differentiation of neuron progenitor cells (NPC’s), angiogenesis, and axonogenesis. Biomaterials are now commonly used to research tissue …
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Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… (ELAC) promote proliferation process in adult neural progenitor cell (NPC) via PKC-activating, thus improving the brain's endogenous neurogenic response to traumatic injury. Occurrence of these compounds on minute amounts on the known sources is a major obstacle to consider them adequate as …
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Chlorpyrifos and chlorpyrifos oxon induce neurite retraction and cytoskeletal disruption in mouse N2a cells and human neural progenitor stem cells
… to inhibit neurite outgrowth in differentiating neural cells but little was known about their ability to cause neurite retraction. The main aims of this study were to investigate the effects of CPF and CPO on the stability of neurites in pre-differentiated mouse N2a neuroblastoma and human …
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An investigation into the characteristics and potential therapeutic application of human neural progenitor cell-derived astrocytes in experimental spinal cord injury
… intervention strategies (including stem/progenitor cells) or, most recently, the application of tissue engineering strategies using biomaterials. The aim of the present study was based on the two latter approaches, combining the growth promoting properties of human neural …
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Analysis and functional characterization in embryonic mouse neocortex of a set of human-specific genes expressed in neural progenitor cells of fetal human neocortex
Einführung: Eine entscheidende Ursache für das Aufkommen der den modernen Menschen charakterisierenden kognitiven Funktionen ist in der beachtlichen Vergrößerung des menschlichen Neocortex innerhalb der letzten 5-7 Millionen Jahre zu finden. Die Identifizierung der dieser Entwicklung zu Grunde …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… integrated neurons are generated from progenitor cells. In the adult mammalian brain two sites of high density cell division have been identified that contain neural progenitor cells retaining the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the …
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Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain
… development requires precise coordination of neural progenitor proliferation and differentiation, the mechanism of which is not well known. Recently the tumor suppressor neurofibromatosis 2 (Nf2) was shown to regulate the balance of neural progenitor proliferation and differentiation in the …
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Investigation of miRNAs Expression in a Citron-Kinase Mutant Model of Microcephaly
… the requirement of miRNAs for differentiation of neural progenitor cells starting at embryonic day 12.5 (3). Together, this evidence links the role of miRNAs to neurogenesis and thus this relationship warrants further investigation. Here miRNA expression has been characterized between the wild …
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Role of Tyrosine Receptor Kinase B in the Development and Function of the Central Nervous System
… of new neurons. Mice lacking TrkB in hippocampal neural progenitor cells had impaired proliferation and neurogenesis, and are behaviorally insensitive to antidepressive treatments. Specific deletion of NF1, an antagonist of Ras, in adult neural progenitor cells enabled rapid proliferative and …
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Activation of Early Neural Progenitors Is Required for Traumatic Brain Injury-Induced Hippocampal Neurogenesis
… control of a nestin promoter and also contains a neural progenitor-specific regulatory element. By using this line, I have demonstrated that eGFP-expressing cells represent early neural progenitors in the adult dentate gyrus. Performing unilateral controlled cortical injury (CCI) demonstrates that …
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