Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Neural Plate"”.
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Mechanism of cell adhesion at the midbrain-hindbrain neural plate in the teleost Danio rerio
The correct development of multicellular organisms is tightly regulated by intrinsic and extrinsic factors at specific time points. Disturbance on any level of these multiple processes may result in drastic phenotypes or eventually death of the organism. The midbrain-hindbrain boundary (also termed …
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Testing the Role of Wnt8a Diffusion in Wnt Mediated Neural Posteriorization
… the anterior posterior (AP) axis of the neural plate. The vertebrate neural plate is subdivided into different morphological domains that define different functional regions. Failure to establish these morphological domains in the correct size have been shown to be associated with …
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Quantitative analysis of the effect of leflunomide on neural crest cell gene regulation during early embryonic development
The neural crest is a transient population of cells that arises at the border between the neural and non-neural ectoderm. These cells are induced, undergo an epithelial-to-mesenchymal transition, and then migrate along stereotypical pathways to form an array of derivatives such as pigment cells, …
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Cellular mechanisms involved in Wnt8 distribution and function in zebrafish neurectoderm patterning
… margin, to the target cells, in the prospective neural plate. For this purpose, I have analysed a biologically active, fluorescently tagged Wnt8 in live zebrafish embryos. Wnt8 was present in live tissue in membrane associated punctate structures. In Wnt8 expressing cells these puncta localise to …
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Function and Regulation of the Conserved Wnt Target sp5 in the Vertebrate Nervous System
… is not well studied. Here we show that during neural patterning, Wnt/β-catenin signaling regulates the transcription of 3 Sp-family genes in zebrafish: sp5a, sp5-like (sp5l) and sp8b. These 3 genes are expressed in the neural plate during embryogenesis. I generated single and double loss of …
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Establishing a positional information assay for brain ventricle mutants and investigating the choroid plexuses in zebrafish
The process by which the neural tube expands into three brain ventricles can be understood through genetic mutant analysis. Within the framework of a characterization of zebrafish mutants with brain ventricle phenotypes, I have developed an assay that looks for evidence of compromised gene …
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Redefining the Gastrula Organiser in Early Chick Embryo Development
… a complete secondary axis with a regionalised neural tube when grafted to an ectopic location. The node also demonstrates extraordinary regenerative capacity: following surgical ablation, it can completely regenerate, and normal development follows. Previous observations suggest that a …
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Cell mechanics-based modelling and in toto imaging describe a new mode of lumen formation in chicken neural tube
… processes that happen sequentially, as the neural tube forms from anterior to posterior. Anteriorly, and early in neurulation, the neural tube closes through primary neurulation, where an already specified neural plate folds into a tube shape that seals. Posteriorly and later in development, …
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Role of the paired-like gene Pitx1 in Xenopus head development.
… domain underlying the centre of presumptive neural plate. Concomitantly, a crescent of expression is observed at the border of anterior neural ectoderm. Expression of xPitx1 persists throughout the cement gland anlage during gastrulation. At the onset of organogenesis, xPitx1 is expressed …
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A new computational model for multi-cellular biological systems
… seen in the formation of the zebrafish forebrain neural plate. Secondly, two proposed hypotheses for the formation of the primitive streak in the chick embryo are investigated and compared. These applications demonstrate how the model can be used to complement experimental studies and help to …
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The Role of Nogo-A During Development of the Chick Central Nervous System
… induction to be coincident with formation of the neural plate, the first visible structure of the CNS. Expression remained diffuse within the neuroepithelia and during later stages of cortical development (proliferation and migration) but showed an increased distribution in large projection …
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. We further reveal an essential role of XSufu in the crosstalk of the two pathways, in which β-catenin activates Hh signalling upon overexpression of Gli1, and Gli inhibits Wnt signalling upon …
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
The neural tube, the precursor to the vertebrate central nervous system, forms through the process of neurulation. During neurulation, a flat neural plate folds and the lateral edges bind to form a closed tube. Failure of neurulation results in neural tube defects (NTD). In humans, NTD causes …
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Characterization of an Enhancer Upstream of Msx3 and its Role in Development of the Neural Tube of Embryonic and Larval Zebrafish
… from an epithelial sheet of cells called the neural plate that subsequently folds to become a rod of cells called the neural tube. Several signaling pathways act on the neural progenitors of the neural tube to give rise to the diverse set of neurons and glia that will make up the spinal cord …
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The zebrafish maternal factor pollywog is required for yolk syncytial layer morphogenesis
… distribution around the yolk. The prechordal plate of pwg mutant embryos deflect laterally or plunge into the yolk, and the overall animalward extension of the prechordal plate is diminished. I also show that the anterior neural plate of pwg mutant embryos fail to converge dorsally to the same …
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Multi-scalar mechanisms timing axial progenitor contribution to the vertebrate body axis
… control ones, and that expression of prospective neural plate marker genes is unchanged after removal of the morphological node. A possible reason for this, despite the hypothesised role for Hensen’s node in neural induction and maintenance, is that expression of many ‘node’ marker genes extends …
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The role of actomyosin contractility in zebrafish neural tube formation through hollowing.
The neural tube is an epithelial tube that forms the embryonic brain and spinal cord through the process of neurulation. In amniotes, it forms in two different ways: in the anterior region, primary neurulation occurs through the folding of an already polarised epithelial sheet; and posteriorly, …
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Funktion und Evolution von hochkonservierten Kopfgenen im Reismehlkäfer Tribolium castaneum
… die Expression und Funktion der Orthologen von Neuralplattengenen aus Vertebraten im Reismehlkäfer Tribolium castaneum analysiert. Basierend auf diesen Daten schlage ich Bestandteile des Regulatorischen Netzwerkes vor, das der anterioren Musterung in Tribolium zugrunde liegt. Einige dieser …