Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Neu1"”.
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Developmental Characterization of the Choroid Plexus in Sialidosis (Neu1 Deficient) Mice
<p>The lysosomal sialidase Neuraminidase-1 (Neu1) initiates the hydrolysis of sialoglycoconjugates by cleaving their terminal sialic acid residues. Neu1 creates a complex with the carboxypeptidase protective protein/cathepsin A (PPCA), which is necessary for its catalytic activation and its …
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Immunomodulatory Roles of the Lysosomal Sialidase Neuraminidase 1
… subcellular compartments. Neuraminidase 1 (NEU1), the most abundant and ubiquitous of the four sialidases, functions primarily in the acidic environment of the lysosomes, but can hydrolyze substrates at the plasma membrane, at least in certain cell types. The enzyme initiates the sequential …
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Caffeine Binding Non-Canonical Biased Adenosine A₂AR GPCR Modulates Neu1 Activation and Signaling in Breast Cancer Cells
… metalloproteinase‑9 (MMP9), and neuraminidase‑1 (Neu1) to modulate cancer‑associated phenotypes in breast cancer cells. Using sialidase assays, we found that caffeine induced Neu1 enzymatic activity in both MDA‑MB‑231 (TNBC) and MCF‑7 (luminal) cells in a dose‑dependent manner. This induction was …
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Role of Neuraminidase-mediated Desialylation in Microglial Activation
… (Abeta ) and tau. Neuraminidase enzyme Neu1 was found on the cell surface of LPS-activated microglia using surface biotinylation and antibody binding experiments. Moreover, knock down of Neu1 reduced the microglial surface sialidase activity induced by LPS, indicating that this enzyme …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… (NMBR), in complex with neuraminidase 1 (Neu1) and matrix metalloproteinase 9 (MMP9). This crosstalk facilitated the glycosylated receptor activation and downstream gene regulation mediated by nuclear factor kappa B (NF-κB). Importantly, cannabinoid type 1 (CB1) receptors have been …
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Investigating the effects of calreticulin and beta-galactosidase on microglial functions and neuronal loss
… enzymes, including neuraminidase 1 (Neu1) and β-galactosidase, play a fundamental role in the degradation of glycoproteins and glycolipids, to maintain cellular constituent turnover and glycosylation homeostasis. Neu1 hydrolyses terminal sialic acid residues to expose galactose …
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Conversion of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors
… FGF2 in combined pairs was able to alter TFAP2A, NEU1, and SLC35A1 expression. The generation of iTr cells by transduction of the Yamanaka reprogramming factors is not unique to equine cells. However, this report marks the generation of the first equine trophoblast cell line capable of …
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The genetics of non-syndromic hearing impairment in South Africa
… c.A17450G, c.A11298C), PDSS1(c.C641T, NEU1(c.C1069T, c.G754C), c.G727A), TBC1D24(c.G1514A), MYO15A(c.C1378T, TMPRSS3(c.205+6t>A), c.9303+5G>A, c.G6634A), USH2A(c.T9437A, c.G2990T, c.G101A), STRC(c.G225A, c.C4057T, c.G4655C, c.C4351T, c.G4403A), P2RX2(c.G1064A, c.C1187G), OTOG(c.C2525A, …