Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Netrin-1"”.
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
… and role of an axon guidance molecule - Netrin-1 in peripheral nerve repair. Using a Schwann cell-specific Netrin-1 knockout mouse model, I showed an increased disorganisation and misdirection of re-growing axons within the nerve bridge following transection injury. However, this did not …
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LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
… options are needed. The neuronal guidance cue netrin-1 has been shown to promote hepatic repair and regeneration during liver ischemia/reperfusion injury, but its effects in APAP hepatotoxicity is unknown. The primary objective of this dissertation was to explore the role of netrin-1 and its …
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The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
… dynamics in response to the axon guidance cue Netrin-1 and its receptor DCC. I have shown Trim9 binds the cytoplasmic tail of DCC and also binds Ena/VASP proteins and Myosin-X, which are cytoskeletal effectors downstream of Netrin-1. I discovered that inhibition of Trim9 ubiquitin ligase …
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Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors Dcc and Neogenin
… in a remarkably precise and stereotyped way. Netrin, a secreted laminin-related protein, provides the major attractive cue for midline guidance. It is thought to act at long-range, functioning either in solution (chemotaxis) or bound to surfaces (haptotaxis). A gradient of Netrin-1 along the …
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The cue induced axonal nascent proteome and its translational control mechanisms in neural wiring
… disease. Axons stimulated by different cues (Netrin-1, BDNF, Sema3A) each show a signature set of up/down newly synthesised protein (NSP) changes (>100) within 5 min. Remarkably, conversion of Netrin-1-induced responses from repulsion to attraction triggers opposite translational regulation …
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Axonal Translation and Links to Neuropathies
… multiple imaging techniques to investigate Netrin-1-induced translation in cultured retinal axons. Total axonal protein synthesis measured by metabolic and puromycin labelling indicates axons experience stage-dependent alterations in translation rate upon Netrin-1 stimulation. Remarkably, …
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Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries
… demonstrate that the neuronal guidance protein, Netrin-1, is highly expressed in infiltrating alveolar macrophages after the onset of ALI. Netrin-1 deletion in the myeloid compartment resulted in exacerbated ALI and increased NK cell recruitment, which was dependent on the upregulation of the …