Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Netherton syndrome"”.
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Pathological meprin alpha expression as a driver of inflammatory skin disease
… in patients with psoriasis vulgaris and Netherton syndrome. Under healthy conditions, meprin a is expressed by keratinocytes of the stratum basale (SB), suggesting a potential function of meprin a in the regulation of keratinocyte proliferation. Although there is mechanistic evidence for …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… associated with rare diseases, such as the Netherton syndrome (NS). In NS epidermis, genetic deficiency of the LEKTI inhibitor of serine proteases results in unopposed activity of KLK5 (and other serine proteases), which promotes skin inflammation via activation of the PAR2-NF-κB-TNFα …