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Showing 1 to 2 of 2 for “"Net1A"”.
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… this study, we have addressed the regulation of Net1A isoform localization by Rac1. Specifically, co-expression of constitutively active Rac1 with Net1A stimulates the relocalization of Net1A from the nucleus to the plasma membrane in breast cancer cells, and results in Net1A activation. …
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The Src- and Abl- Dependent Regulation of Net1A In Breast Cancer
… metastasis. Two isoforms of Net1 exist, Net1 and Net1A, both of which are which sequestered in the nucleus in quiescent cells to prevent aberrant RhoA activation. Many cell motility stimuli drive cytosolic relocalization of Net1A, but mechanisms controlling this event are not fully understood. …