Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 78 for “"Nervous System Diseases"”.
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A survey of central nervous system diseases of Michigan cattle
Thesis (M.S.)--Michigan State University. Dept. of Pathology, 1973
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Analysis of Cell-Cell Interactions in the Formation of Drosophila Antennal Lobes
… of Neuroglian and Limk have been linked to human nervous system diseases, CRASH syndrome and Williams syndrome, respectively. The characterization of these two conserved genes in the Drosophila brain extends our knowledge of their cellular functions and helps to shed light on the pathology of …
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
… in neurons in the central and peripheral nervous systems. These ion channels are sensors for extracellular pH and contribute to a variety of normal functions including learning and memory, seizure termination, fear, anxiety, and pain. Additionally, ASICs mediate neuron death and axon …
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A high-throughput antiepileptic drug screening system based on chemically Induced zebrafish behavioral model
… has the largest worldwide impacts among all nervous system diseases expect for stroke and dementia, is a group of long-term neurological disorders characterized by epileptic seizures. AED medications are the mainstay for epileptic seizure management. However, the existing AEDs cannot fit the …
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Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis
… produced by neurons in the central nervous system (CNS) and by some species of intestinal bacteria. GABAA receptors are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that GABA can have an anti-inflammatory effect and production …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
<p>During peripheral nervous system development, successful communication between axons and glial cells including Schwann cells in peripheral nervous system and oligodendrocytes in central nervous system, is required for the proper functions of both neurons and glia. Three types of …
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The role of diet therapy in chronic kidney disease
… mineral and bone disorders, and peripheral nervous system diseases. Those with kidney failure require dialysis or kidney transplantation, as well as medications, diet therapy, restriction of fluid intake, and lifestyle modifications. The cost for such treatment represents an enormous burden …
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Ensemble of classifiers based data fusion of EEG and MRI for diagnosis of neurodegenerative disorders
… depends on the ability to diagnose these diseases at the earliest stages. To facilitate the availability of early diagnosis in community hospitals, an accurate, inexpensive, and noninvasive diagnostic tool must be made available. As biomarkers, the event related potentials (ERP) of the …
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Journey with Autism: Successful Educational and Social Interventions from a Single Case Study
<p>Problem</p> <p>Statistics indicate that Autism Spectrum Disorder (ASD) is on the increase in America and worldwide (Xu, Strathearn, Liu, & Bao, 2018; Baio et al., 2018). Autism spectrum disorder can impair an individual’s ability to engage in neurotypical behavior, which has the potential to …
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Role of Gigaxonin in the Regulation of Intermediate Filaments: a Study Using Giant Axonal Neuropathy Patient-Derived Induced Pluripotent Stem Cell-Motor Neurons
… shed light on GAN as well as the numerous other diseases in which IFs accumulate. However, an interaction between gigaxonin and IFs has not been detected and how IF accumulation is triggered in the absence of functional gigaxonin has not been determined. To address these questions I undertook a …
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Retinoid X Receptor as a Mediator of Post Stroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Macrophages
<p>After stroke, microglia (MG) and blood-derived macrophages, together (MF), clear dead cells and cellular debris in the infarcted brain through phagocytosis. However, the phagocytic capability of MF declines with age. Age-related changes in MF phenotype also include overactive inflammatory …
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Polyglutamine monomer structure and its implications for molecular self-assembly
… has been implicated in several neurodegenerative diseases, including Huntington's disease. The resulting aggregates have been demonstrated to possess ~-sheet structure, and aggregation has been shown to start with a single misfolded peptide. The current project sought to computationally examine …
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The clinical utility of multidisciplinary rehabilitation in individuals with Huntington’s Disease
… features. Individuals also display a variety of systemic features. Progressive neuronal dysfunction and neuronal cell death are thought to underlie the onset and progression of many clinical features of HD. Despite scientific progress, there is still no cure or disease modifying therapy for HD, …
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Role of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 and In Immature Neurons
<p>Spinocerebellar Ataxia type 7 (SCA7) is a neurodegenerative disease caused by expansion of a CAG repeat encoding a polyglutamine tract in ATXN7, a component of the SAGA histone acetyltransferase (HAT) complex. Previous studies provided conflicting evidence regarding the effects of polyQ-ATXN7 on …
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Deciphering The Role of Huntingtin In Endosomal Functions
… orchestraed by Rab GTPases. In particular, I systematically tested HTT’s effect on the production of phosphatidylinositol phosphates, the sizes and maturation of endosomes and lysosomes such as lysosomal acidification, and the subcellular distribution of different endosomal markers. My …
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Investigating the Role of Insulin-Like Signaling in Paclitaxel-Induced Nociceptive Hypersensitivity using Drosophila melanogaster
<p>Paclitaxel (PTX), a chemotherapeutic that alters microtubule dynamics, is known to induce nociceptive hypersensitivity and sensory neuron damage in human patients and in Drosophila larvae. We used a modified feeding protocol to establish a genetically tractable Drosophila model of PTX-induced …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… is associated with various age-related diseases including diabetic complications and neurodegenerative diseases. Aging and long-term hyperglycemia causes enhanced production of this highly reactive α-dicarbonyl, which reacts with macromolecules causing irreversible damage of DNA and …
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Causal Inference Methods for Estimation of Survival and General Health Status Measures of Alzheimer’s Disease Patients
… health records obtained from over 110 health systems in the United States. We also analyzed demographic variables, preexisting conditions, and drug treatments. Our results show that the combined use of Donepezil and Memantine significantly increased the probability of three, four and five-year …
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