Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Nerve injury"”.
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Behavioral Pharmacological Analysis of Deep Brain Stimulation Following Nerve Injury
Treatment of neuropathic pain remains a major unmet public health problem. Serious concerns arise over misuse of prescription opioids in chronic pain patients, a drug class representing the fastest growing substance abuse problem in the United States. Ascending pain pathways overlap significantly …
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Sex-dependent and Sex-independent Gene Regulation after Peripheral Nerve Injury
Peripheral nerve injury (PNI) induces cascades of gene expression changes in the central nervous system (CNS). However, there are still many uncertainties regarding the mechanisms of gene regulation that are sex-dependent and sex-independent. In this study, I examined the sex differences and …
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Dysphagia and recurrent laryngeal nerve injury in anterior cervical discectomy and fusion
… contribute to dysphagia and recurrent laryngeal nerve palsy complications following ACDF surgery. Objective: 1. To determine the rates of dysphagia and recurrent laryngeal nerve complications following ACDF reported in the literature and potential associated factors. 2. To determine rates of …
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The control of Schwann cell myelination during development and after nerve injury
… and myelination during development and after injury. In addition, we aimed to investigate for the first time the specific role of p38α (the major isoform of p38 MAPK) in Schwann cell myelination in vivo, by generating Schwann cell specific p38α conditional knockout mice. Sox2 is highly …
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Biomedical and Psychosocial Factors Associated with Pain and Disability after Peripheral Nerve Injury
… in patients following traumatic upper extremity nerve injuries. This was approached by conducting 3 studies. The first study surveyed peripheral nerve surgeons regarding the assessment of pain in patients with nerve injury. The results showed that only 52% of surgeons always evaluate pain in …
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Effects of Electrical Stimulation and Testosterone in Translational Models of Peripheral Nerve Injury
<p>As functional recovery following peripheral nerve injury is dependent upon successful regeneration and target reconnection, combinatorial treatments that enhance different regeneration events may be required for recovery from severe injuries. The neurotherapeutic effects of electrical …
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Effects of Electrical Stimulation and Testosterone in Translational Models of Facial Nerve Injury
… nervous system injuries seen clinically, facial nerve lesions are prevalent and have significant functional and emotional impact on patients. As injuries can occur in different segments of the facial nerve and lead to different pathophysiological outcomes, animal models that mimic the common …
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Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
Facial nerve axotomy (FNA) in immunodeficient mice causes significantly more facial motoneuron (FMN) loss relative to wild type (WT), indicating that the immune system is neuroprotective. Further studies reveal that both CD4+ T cells and interleukin 10 (IL-10) act centrally to promote neuronal …
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The role of ErbB inhibitors in promoting nerve regeneration in a mouse model of nerve injury
Nerve injury is a common clinical challenge that has a considerable impact on an individual’s quality of life and function. Despite multiple surgical strategies, functional outcomes following nerve injury remain poor. Increasing the rate at which axons regenerate could profoundly improve the …
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Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
… to serve as a potential treatment for peripheral nerve injury. The use of an affinity-based delivery system: ABDS) with growth factors in a nerve guidance conduit: NGC) was hypothesized to promote nerve regeneration and functional recovery following a critical nerve defect. Evaluation of …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… a spontaneous model of glaucoma.</p> <p>Optic nerve crush is a model of retinal ganglion cell (RGC) death. Crushing the optic nerve causes the axons to undergo Wallerian degeneration and apoptotic loss of retinal ganglion cells over time. This pattern of cell death is very similar to that …
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THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION
… determinant of recovery after peripheral nerve injury. With aging, there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after …
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Plasticity of neurons in mouse major pelvic ganglia in response to loos of physiological input in cases of nerve injury and spinal cord injury
… patients. Most people with spinal cord injury (SCI) reported a desire to recover autonomic functions such as bladder and sexual functions over regaining of locomotor functions. Lower urinary tract function is one of the autonomic functions that is impaired after SCI. Acute SCI results in …
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Median and Ulnar Nerve Injuries in Children and Adolescents- Long-term outcome and Cerebral reorganisation
A peripheral nerve injury may lead to serious disability and influence the individual´s quality of life. It is considered that children can regain better sensory and motor function after a peripheral nerve injury, but the exact mechanism behind such superior recovery is not known. The aim of the …
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Effects of electrical stimulation and testosterone on regeneration-associated gene expression and functional recovery in a rat model of sciatic nerve crush injury
… is often suboptimal following peripheral nerve injury (PNI). Research to date indicates that the greatest success in achieving full functional recovery will require the use of a combinatorial approach that can simultaneously target different aspects of the post-injury response. In general, …
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The Rat as a Translational Model of Neurotrauma: Primary Somatosensory Input and Imaging Biomarker Validation Following Spinal Cord and Peripheral Nerve Injuries
… standardizable and quantifiable models of injury. Rats are the most commonly used models of spinal cord (SCI) and peripheral nerve (PNI) injuries because their anatomy and physiology approximates that of humans, while their size and management make them economical and practical for large …
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